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Polr3a Gene Detail
Summary
  • Symbol
    Polr3a
  • Name
    polymerase (RNA) III (DNA directed) polypeptide A
  • Synonyms
    9330175N20Rik, MGC:62420, RPC1, RPC155
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681836
    NCBI Gene: 218832
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:24448696-24487058 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 14.40 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    225 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2681836
protein coding gene Chr14:24448694-24487188 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021063
protein coding gene Chr14:17389384-17428908 (-)
A/J MGP_AJ_G0021012
protein coding gene Chr14:16959636-16997925 (-)
AKR/J MGP_AKRJ_G0020989
protein coding gene Chr14:17574837-17616968 (-)
BALB/cJ MGP_BALBcJ_G0021015
protein coding gene Chr14:17059389-17097976 (-)
C3H/HeJ MGP_C3HHeJ_G0020799
protein coding gene Chr14:17502851-17543724 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021448
protein coding gene Chr14:17963831-18002168 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019016
protein coding gene Chr14:17159931-17199269 (-)
CAST/EiJ MGP_CASTEiJ_G0020323
protein coding gene Chr14:17352512-17397139 (-)
CBA/J MGP_CBAJ_G0020765
protein coding gene Chr14:18854190-18892576 (-)
DBA/2J MGP_DBA2J_G0020888
protein coding gene Chr14:16776744-16815779 (-)
FVB/NJ MGP_FVBNJ_G0020871
protein coding gene Chr14:16638992-16677330 (-)
LP/J MGP_LPJ_G0020964
protein coding gene Chr14:17671159-17709521 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020897
protein coding gene Chr14:18566807-18613311 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021481
protein coding gene Chr14:17381875-17420261 (-)
PWK/PhJ MGP_PWKPhJ_G0020072
protein coding gene Chr14:16361234-16404080 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019894
protein coding gene Chr14:17186393-17238615 (-)
WSB/EiJ MGP_WSBEiJ_G0020379
protein coding gene Chr14:17369046-17410352 (-)



Homology
more
  • Human Ortholog
    POLR3A, RNA polymerase III subunit A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    POLR3A, RNA polymerase III subunit A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADDH, HLD7, hRPC155, RPC1, RPC155, WDRTS
  • Links
    NCBI Gene ID: 11128
    neXtProt AC: NX_O14802
    UniProt: O14802

  • Chr Location
    10q22.3; chr10:77975149-78029540 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5124
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: POLR3A
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human POLR3A associations

Human Disease Mouse Models
      
IDs
View 2 "NOT" models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025280 Ensembl Gene Model | MGI Sequence Detail 38363 C57BL/6J ±  kb
transcript ENSMUST00000026322 Ensembl | MGI Sequence Detail 4687 Not Applicable  
polypeptide ENSMUSP00000026322 Ensembl | MGI Sequence Detail 1390 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR035698 DNA-directed RNA polymerase III subunit RPC1, C-terminal
    IPR035697 DNA-directed RNA polymerase III subunit RPC1, N-terminal
    IPR000722 RNA polymerase, alpha subunit
    IPR006592 RNA polymerase, N-terminal
    IPR007080 RNA polymerase Rpb1, domain 1
    IPR007066 RNA polymerase Rpb1, domain 3
    IPR042102 RNA polymerase Rpb1, domain 3 superfamily
    IPR007083 RNA polymerase Rpb1, domain 4
    IPR007081 RNA polymerase Rpb1, domain 5
    IPR038120 RNA polymerase Rpb1, funnel domain superfamily
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
Other
Accession IDs
less
MGI:1924764
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:250577 Choquet K, et al., Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation. Mol Brain. 2017 Apr 13;10(1):13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory