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Chsy1
Gene Detail
Symbol

Name
ID
Chsy1
chondroitin sulfate synthase 1
MGI:2681120
Synonyms
mKIAA0990
Feature Type
protein coding gene
Genetic Map
Chromosome 7
35.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:66109515-66173789 bp, + strand
From VEGA annotation of GRCm38

  64275 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8950  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CHSY1
Gene Tree: Chsy1

Human
homologs
CHSY1, chondroitin sulfate synthase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 22856
neXtProt AC: NX_Q86X52

Human Synonyms: CHSY, ChSy-1, CSS1, TPBS

Human Chr (Location): 15q26.3; chr15:101175723-101251932 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CHSY1

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mice are viable, but display chondrodysplasia, brachydactyly and decreased bone density. Retinal degeneration, impaired motor strength, and hematological abnormalities are also seen.
 
Interactions
Chsy1 interacts with 250 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Expression
Literature Summary: (3 records)
Data Summary: Results (94)    Tissues (94)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(53)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase chsy1 ; ZFIN chsy1    NEW 
Molecular
reagents
All nucleic(54) cDNA(53) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000029829 (Evidence)
Ensembl Gene Model ENSMUSG00000032640 (Evidence)
Entrez Gene 269941 (Evidence)
UniGene 333916
DFCI TC1600833
DoTS DT.534271, DT.87033096
NIA Mouse Gene Index U008189
EC 2.4.1.175, 2.4.1.226
Consensus CDS Project CCDS39978.1
International Mouse Phenotyping Consortium Status Chsy1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029829 VEGA Gene Model | MGI Sequence Detail 64275 C57BL/6J ±  kb
transcript OTTMUST00000074032 VEGA | MGI Sequence Detail 4167 Not Applicable 
polypeptide OTTMUSP00000038400 VEGA | MGI Sequence Detail 800 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(743 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008428 Chondroitin N-acetylgalactosaminyltransferase
InterPro IPR027791 Galactosyltransferase, C-terminal
InterPro IPR029044 Nucleotide-diphospho-sugar transferases
Protein Ontology PR:000005483 chondroitin sulfate synthase 1
References
(Earliest) J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
(Latest) J:191659 Ogawa H, et al., Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development. PLoS One. 2012;7(8):e43806
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory