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Slitrk1
Gene Detail
Symbol

Name
ID
Slitrk1
SLIT and NTRK-like family, member 1
MGI:2679446
Synonyms
3200001I04Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 14
56.78 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:108909991-108914239 bp, - strand
From Ensembl annotation of GRCm38

  4249 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14174  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLITRK1
Gene Tree: Slitrk1

Human
homologs
SLITRK1, SLIT and NTRK-like family, member 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 114798
neXtProt AC: NX_Q96PX8

Human Synonyms: LRRC12, TTM

Human Chr (Location): 13q31.1; chr13:83877205-83882393 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SLITRK1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display hypoactivity, reduced male body weight, elevated anxiety- and depression-like behavior, increased norepinephrine content in brain, and partial postnatal lethality.
 
Human Diseases Modeled in Mice Using Slitrk1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Slitrk1 interacts with 258 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process adult behavior, axonogenesis, ...
Component integral component of membrane, membrane
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (298)    Tissues (107)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 251
Northern blot 29
Western blot 18
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slitrk1    NEW 
Molecular
reagents
All nucleic(34) cDNA(32) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000075478 (Evidence)
Entrez Gene 76965 (Evidence)
UniGene 257268
DFCI TC1701034
DoTS DT.101139273
NIA Mouse Gene Index U135089
Consensus CDS Project CCDS27325.1
International Mouse Phenotyping Consortium Status Slitrk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000075478 Ensembl Gene Model | MGI Sequence Detail 4249 C57BL/6J ±  kb
transcript ENSMUST00000100322 Ensembl | MGI Sequence Detail 4249 Not Applicable 
polypeptide ENSMUSP00000097897 Ensembl | MGI Sequence Detail 696 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000015237 SLIT and NTRK-like protein 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:211830 Um JW, et al., Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep. 2014 Mar 27;6(6):1096-109
All references(38)
Disease annotation references (1)
Other
accession IDs
MGI:1924215

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory