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Rgma Gene Detail
Summary
  • Symbol
    Rgma
  • Name
    repulsive guidance molecule family member A
  • Synonyms
    MGC:38550, MGC:69915, RGM domain family, member A
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679262
    NCBI Gene: 244058
  • Gene Overview
    MyGene.info: RGMA
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:73375520-73419899 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 41.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    176 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679262
protein coding gene Chr7:73375509-73419899 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032368
protein coding gene Chr7:74927994-74973760 (+)
A/J MGP_AJ_G0032347
protein coding gene Chr7:73245068-73289433 (+)
AKR/J MGP_AKRJ_G0032283
protein coding gene Chr7:74779368-74822968 (+)
BALB/cJ MGP_BALBcJ_G0032359
protein coding gene Chr7:73002353-73044940 (+)
C3H/HeJ MGP_C3HHeJ_G0032072
protein coding gene Chr7:75550057-75599572 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032851
protein coding gene Chr7:78029336-78075261 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029859
protein coding gene Chr7:75887168-75931138 (+)
CAST/EiJ MGP_CASTEiJ_G0031400
protein coding gene Chr7:66364485-66413169 (+)
CBA/J MGP_CBAJ_G0032038
protein coding gene Chr7:80558713-80614368 (+)
DBA/2J MGP_DBA2J_G0032193
protein coding gene Chr7:71913290-71955196 (+)
FVB/NJ MGP_FVBNJ_G0032148
protein coding gene Chr7:71967455-72009943 (+)
LP/J MGP_LPJ_G0032274
protein coding gene Chr7:76154780-76201413 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032185
protein coding gene Chr7:80716573-80759158 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032869
protein coding gene Chr7:74248353-74294556 (+)
PWK/PhJ MGP_PWKPhJ_G0031120
protein coding gene Chr7:65054515-65101077 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030961
protein coding gene Chr7:61314772-61364687 (+)
WSB/EiJ MGP_WSBEiJ_G0031518
protein coding gene Chr7:74591555-74637331 (+)



Homology
more
  • Human Ortholog
    RGMA, repulsive guidance molecule BMP co-receptor a
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RGMA, repulsive guidance molecule BMP co-receptor a
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RGM
  • Links
    NCBI Gene ID: 56963
    neXtProt AC: NX_Q96B86
    UniProt: Q96B86

  • Chr Location
    15q26.1; chr15:93043406-93089214 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10626
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RGMA
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Inactivation of this locus results in impaired cephalic closure and subsequent exencephaly, both with incomplete penetrance. The retinal topography of the visual system is normal in homozygous mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 244058 NCBI Gene Model | MGI Sequence Detail 44380 C57BL/6J ±  kb
    transcript NM_177740 RefSeq | MGI Sequence Detail 3586 C57BL/6  
    polypeptide Q6PCX7 UniProt | EBI | MGI Sequence Detail 454 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR016123 Mog1/PsbP, alpha/beta/alpha sandwich
      IPR033607 Repulsive guidance molecule A
      IPR009496 Repulsive guidance molecule, C-terminal
      IPR010536 Repulsive guidance molecule, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 55
      Primer pair 2
      Other 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 15
      Gene Ontology 10
      Phenotypes 15
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:235517 Kam JW, et al., RGMB and neogenin control cell differentiation in the developing olfactory epithelium. Development. 2016 May 1;143(9):1534-46

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory