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Rgma Gene Detail
Summary
  • Symbol
    Rgma
  • Name
    repulsive guidance molecule family member A
  • Synonyms
    MGC:38550, MGC:69915, RGM domain family, member A
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679262
    NCBI Gene: 244058
  • Gene Overview
    MyGene.info: RGMA
Location & Maps
more
  • Sequence Map
    Chr7:73375509-73419899 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      44391 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 41.85 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RGMA, repulsive guidance molecule family member a
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RGMA, repulsive guidance molecule family member a
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RGM
  • Links
    NCBI Gene ID: 56963
    neXtProt AC: NX_Q96B86

  • Chr Location
    15q26.1; chr15:93043406-93089214 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 10626
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RGMA
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    3 involving Rgma
  • Incidental Mutations
Inactivation of this locus results in impaired cephalic closure and subsequent exencephaly, both with incomplete penetrance. The retinal topography of the visual system is normal in homozygous mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031394 VEGA Gene Model | MGI Sequence Detail 44391 C57BL/6J ±  kb
transcript OTTMUST00000077776 VEGA | MGI Sequence Detail 3586 Not Applicable  
polypeptide OTTMUSP00000041210 VEGA | MGI Sequence Detail 454 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    176 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 56
    cDNA 54
    Primer pair 1
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 44
    Developmental Gene Expression 14
    Gene Ontology 9
    Phenotypes 15
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:235517 Kam JW, et al., RGMB and neogenin control cell differentiation in the developing olfactory epithelium. Development. 2016 May 1;143(9):1534-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory