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Rgma
Gene Detail
Symbol

Name
ID
Rgma
repulsive guidance molecule family member A
MGI:2679262
Synonyms
MGC:38550, MGC:69915, RGM domain family, member A
Feature Type
protein coding gene
Genetic Map
Chromosome 7
41.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:73375520-73419899 bp, + strand
From VEGA annotation of GRCm38

  44380 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10626  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rgma

Human
homologs
Human Homolog RGMA, repulsive guidance molecule family member a
NCBI Gene ID 56963
neXtProt AC  NX_Q96B86
Human Synonyms  RGM
Human Chr (Location)  15q26.1; chr15:93043406-93089214 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(3) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of this locus results in impaired cephalic closure and subsequent exencephaly, both with incomplete penetrance. The retinal topography of the visual system is normal in homozygous mutant mice.
 
Interactions
Rgma interacts with 261 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process BMP signaling pathway, neural tube closure, ...
Component anchored component of membrane, cell surface, ...
Function coreceptor activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (283)    Tissues (63)    Images (51)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 262
Western blot 6
RT-PCR 13
cDNA source data(53)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) cDNA(53) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000031394 (Evidence)
Ensembl Gene ModelENSMUSG00000070509 (Evidence)
Entrez Gene244058 (Evidence)
UniGene333943
DFCITC1595845, TC1590021, TC1583813
Consensus CDS ProjectCCDS21362.2
International Mouse Knockout Project StatusRgma
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031394 VEGA Gene Model | MGI Sequence Detail 44380 C57BL/6J ±  kb
transcript OTTMUST00000077776 VEGA | MGI Sequence Detail 3586 Not Applicable 
polypeptide OTTMUSP00000041210 VEGA | MGI Sequence Detail 454 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(177 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009496 Repulsive guidance molecule, C-terminal
InterPro IPR010536 Repulsive guidance molecule, N-terminal
Protein Ontology PR:000013940 repulsive guidance molecule A
References
(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:199400 van den Heuvel DM, et al., Spatiotemporal expression of repulsive guidance molecules (RGMs) and their receptor neogenin in the mouse brain. PLoS One. 2013;8(2):e55828
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory