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Mir200b Gene Detail
Summary
  • Symbol
    Mir200b
  • Name
    microRNA 200b
  • Synonyms
    Mirn200b, mmu-mir-200b
  • Feature Type
    miRNA gene
  • IDs
    MGI:2676875
    NCBI Gene: 387243
  • Member of
    Mirc4 cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr4:156140138-156140207 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 87.96 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    51 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676875
 miRNA gene Chr4:156140138-156140207 (-)
129S1/SvImJ MGP_129S1SvImJ_G0008793
 miRNA gene Chr4:160426948-160427017 (-)
A/J MGP_AJ_G0008776
 miRNA gene Chr4:153667086-153667155 (-)
AKR/J MGP_AKRJ_G0008768
 miRNA gene Chr4:157847989-157848058 (-)
BALB/cJ MGP_BALBcJ_G0008766
 miRNA gene Chr4:154141588-154141657 (-)
C3H/HeJ MGP_C3HHeJ_G0008706
 miRNA gene Chr4:158409622-158409691 (-)
C57BL/6NJ MGP_C57BL6NJ_G0008988
 miRNA gene Chr4:166117014-166117083 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0007928
 miRNA gene Chr4:145945185-145945254 (-)
CAST/EiJ MGP_CASTEiJ_G0008546
 miRNA gene Chr4:155848897-155848966 (-)
CBA/J MGP_CBAJ_G0008672
 miRNA gene Chr4:171151896-171151965 (-)
DBA/2J MGP_DBA2J_G0008702
 miRNA gene Chr4:153688544-153688613 (-)
FVB/NJ MGP_FVBNJ_G0008722
 miRNA gene Chr4:152935005-152935074 (-)
LP/J MGP_LPJ_G0008797
 miRNA gene Chr4:160364389-160364458 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0008688
 miRNA gene Chr4:173946307-173946376 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0008969
 miRNA gene Chr4:158494429-158494498 (-)
PWK/PhJ MGP_PWKPhJ_G0008477
 miRNA gene Chr4:149828973-149829042 (-)
SPRET/EiJ MGP_SPRETEiJ_G0008329
 miRNA gene Chr4:152740213-152740282 (-)
WSB/EiJ MGP_WSBEiJ_G0008644
 miRNA gene Chr4:158660218-158660287 (-)



Homology
more
  • Human Ortholog
    MIR200B, microRNA 200b
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR200B, microRNA 200b
  • Synonyms
    mir-200b, MIRN200B
  • Links
    NCBI Gene ID: 406984

  • Chr Location
    chr1:1167104-1167198 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MIR200B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from multigenic genotypes
    4 phenotype references
Mice homozygous for knock-out alleles for Mir429 and Mir200b exhibit reduced female ferility due to reduced ovulation and impaired luteinizing hormone production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    780
  • Tissues
    31
  • Literature Summary
    23
Sequences &
Gene Models
less
  • All Sequences
    24
  • RefSeq
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic 387243 NCBI Gene Model | MGI Sequence Detail 70 C57BL/6J ±  kb
transcript NR_029587 RefSeq | MGI Sequence Detail 70 C57BL/6  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 7
    Primer pair 3
    Other 4
Other Database
Links
less
miRBase MI0000243
References
more
  • Summaries
    All 61
    Developmental Gene Expression 23
    Gene Ontology 8
    Phenotypes 4
  • Earliest
    J:84908 Lagos-Quintana M, et al., New microRNAs from mouse and human. RNA. 2003 Feb;9(2):175-9
  • Latest
    J:331421 Funato N, et al., TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties. Sci Rep. 2022 Nov 23;12(1):20188
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory