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Mir146 Gene Detail
Summary
  • Symbol
    Mir146
  • Name
    microRNA 146
  • Synonyms
    miR-146a, Mirn146, mmu-mir-146, mmu-mir-146a
  • Feature Type
    miRNA gene
  • IDs
    MGI:2676831
    NCBI Gene: 387164
  • Gene Overview
    MyGene.info: MIR146A
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr11:43374397-43374461 bp, - strand
  • From miRBase annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 25.68 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676831
miRNA gene Chr11:43374397-43374461 (-)
129S1/SvImJ MGP_129S1SvImJ_G0007796
miRNA gene Chr11:42127279-42127343 (-)
A/J MGP_AJ_G0007792
miRNA gene Chr11:40525837-40525901 (-)
AKR/J MGP_AKRJ_G0007766
miRNA gene Chr11:41715902-41715966 (-)
BALB/cJ MGP_BALBcJ_G0007769
miRNA gene Chr11:40696600-40696664 (-)
C3H/HeJ MGP_C3HHeJ_G0007716
miRNA gene Chr11:41746373-41746437 (-)
C57BL/6NJ MGP_C57BL6NJ_G0007947
miRNA gene Chr11:43421001-43421065 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0007093
miRNA gene Chr11:38596841-38596905 (-)
CAST/EiJ MGP_CASTEiJ_G0007609
miRNA gene Chr11:41797033-41797097 (-)
CBA/J MGP_CBAJ_G0007688
miRNA gene Chr11:45417194-45417258 (-)
DBA/2J MGP_DBA2J_G0007722
miRNA gene Chr11:40317068-40317132 (-)
FVB/NJ MGP_FVBNJ_G0007740
miRNA gene Chr11:40002648-40002712 (-)
LP/J MGP_LPJ_G0007800
miRNA gene Chr11:42376409-42376473 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0007710
miRNA gene Chr11:47077455-47077519 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0007945
miRNA gene Chr11:41866301-41866365 (-)
PWK/PhJ MGP_PWKPhJ_G0007539
miRNA gene Chr11:40334373-40334437 (-)
SPRET/EiJ MGP_SPRETEiJ_G0007435
miRNA gene Chr11:41662426-41662490 (-)
WSB/EiJ MGP_WSBEiJ_G0007677
miRNA gene Chr11:41506783-41506847 (-)



Homology
more
  • Human Ortholog
    MIR146A, microRNA 146a
  • Human Ortholog
    MIR146A, microRNA 146a
    Orthology source: HGNC
  • Synonyms
    miR-146a, MIRN146, MIRN146A, miRNA146A
  • Links
    NCBI Gene ID: 406938

  • Chr Location
    chr5:160485352-160485450 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 3 alleles in 4 genetic backgrounds
    11 phenotypes from multigenic genotypes
    3 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased sensitivity to LPS and develop a lympho- and myeloproliferative syndrome.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 387164 NCBI Gene Model | MGI Sequence Detail 65 C57BL/6J ±  kb
    transcript NR_029558 RefSeq | MGI Sequence Detail 65 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 2
      Primer pair 1
      Other 1
    Other Database
    Links
    less
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 34
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:270870 Bertolet G, et al., MiR-146a wild-type 3' sequence identity is dispensable for proper innate immune function in vivo. Life Sci Alliance. 2019 Feb;2(1)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    04/09/2019
    MGI 6.13
    The Jackson Laboratory