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Mir146
Gene Detail
Symbol

Name
ID
Mir146
microRNA 146
MGI:2676831
Synonyms
miR-146a, Mirn146, mmu-mir-146, mmu-mir-146a
Feature Type
miRNA gene
Genetic Map
Chromosome 11
25.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:43374397-43374461 bp, - strand
From miRBase annotation of GRCm38

  65 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
Gene Tree: Mir146
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Mice homozygous for a knock-out allele exhibit increased sensitivity to LPS and develop a lympho- and myeloproliferative syndrome.
 
Human Diseases Modeled in Mice Using Mir146 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Mir146 interacts with 6574 markers (0610009O20Rik, 0610010F05Rik, 0610030E20Rik, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process cellular response to estrogen stimulus, cellular response to lipopolysaccharide, ...
Expression
Literature Summary: (8 records)
Data Summary: Results (6)    Tissues (4)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 3
RT-PCR 3
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(3) Primer pair(1) Other(2)
Other database
links
Ensembl Gene Model ENSMUSG00000065601 (Evidence)
Entrez Gene 387164 (Evidence)
miRBase MI0000170
International Mouse Phenotyping Consortium Status Mir146
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 387164 NCBI Gene Model | MGI Sequence Detail 65 C57BL/6J ±  kb
transcript NR_029558 RefSeq | MGI Sequence Detail 65 C57BL/6 

For the selected sequences
All sequences(6) RefSeq(1)
Polymorphisms
SNPs within 2kb(29 from dbSNP Build 137)
References
(Earliest) J:84907 Lagos-Quintana M, et al., Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002 Apr 30;12(9):735-9
(Latest) J:221898 Pratama A, et al., MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres. Nat Commun. 2015;6:6436
All references(43)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory