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Mir146
Gene Detail
 Symbol
Name
ID
Mir146
microRNA 146
MGI:2676831
BioType Conflict
Synonyms miR-146a, Mirn146, mmu-mir-146, mmu-mir-146a
Feature Type miRNA gene
Genetic Map
Chromosome 11
25.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:43374397-43374461 bp, - strand
From miRBase annotation of GRCm38

  65 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
Gene Tree: Mir146
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Mice homozygous for a knock-out allele exhibit increased sensitivity to LPS and develop a lympho- and myeloproliferative syndrome.
 
Human Diseases Modeled Using Mouse Mir146 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process cellular response to estrogen stimulus, cellular response to lipopolysaccharide, ...
Expression
Literature Summary: (6 records)
Data Summary: Results (6)    Tissues (4)    Images (1)
Theiler Stages: 15, 17, 19, 28
Assay TypeResults
Northern blot 3
RT-PCR 3
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(3) Primer pair(1) Other(2)
Other database
links
Ensembl Gene ModelENSMUSG00000065601 (Evidence)
Entrez Gene387164 (Evidence)
miRBaseMI0000170
International Mouse Knockout Project StatusMir146
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 387164 NCBI Gene Model | MGI Sequence Detail 65 C57BL/6J ±  kb
transcript NR_029558 RefSeq | MGI Sequence Detail 65 C57BL/6 

For the selected sequences
All sequences(5) RefSeq(1)
Polymorphisms SNPs within 2kb(29 from dbSNP Build 137)
References (Earliest) J:84907 Lagos-Quintana M, et al., Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002 Apr 30;12(9):735-9
(Latest) J:200243 Schulte LN, et al., Differential activation and functional specialization of miR-146 and miR-155 in innate immune sensing. Nucleic Acids Res. 2013 Jan 7;41(1):542-53
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory