Mir146
Gene Detail

Symbol Name ID

Mir146 microRNA 146 MGI:2676831

Synonyms

miR-146a, Mirn146, mmu-mir-146, mmu-mir-146a

Feature Type

miRNA gene

Genetic Map

Chromosome 11

25.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:43374397-43374461 bp, - strand From miRBase annotation of GRCm38   65 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

Gene Tree: Mir146

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele exhibit increased sensitivity to LPS and develop a lympho- and myeloproliferative syndrome.

 
Human Diseases Modeled Using Mouse Mir146 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Process

cellular response to estrogen stimulus, cellular response to lipopolysaccharide, ...

Expression

Literature Summary: (6 records)
Data Summary: Results (6)    Tissues (4)    Images (1)
Theiler Stages: 15, 17, 19, 28

Assay Type	Results
Northern blot	3
RT-PCR	3

External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(3) Primer pair(1) Other(2)

Other database links

Ensembl Gene Model	ENSMUSG00000065601 (Evidence)
Entrez Gene	387164 (Evidence)
miRBase	MI0000170
International Mouse Knockout Project Status	Mir146

Sequences

Length	Strain/Species
genomic	387164	NCBI Gene Model | MGI Sequence Detail	65	C57BL/6J
transcript	NR_029558	RefSeq | MGI Sequence Detail	65	Not Specified

All sequences(5) RefSeq(1)

References

(Earliest) J:84907 Lagos-Quintana M, et al., Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002 Apr 30;12(9):735-9
(Latest) J:191831 Yang L, et al., miR-146a controls the resolution of T cell responses in mice. J Exp Med. 2012 Aug 27;209(9):1655-70
All references(28)