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Mir145a Gene Detail
Summary
  • Symbol
    Mir145a
  • Name
    microRNA 145a
  • Synonyms
    Mirn145, mmu-mir-145, mmu-mir-145a
Location &
Maps
more
  • Sequence Map
    Chr18:61647825-61647894 bp, - strand
  • From miRBase annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 34.64 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676830
miRNA gene Chr18:61647825-61647894 (-)
129S1/SvImJ MGP_129S1SvImJ_G0008395
miRNA gene Chr18:61547379-61547448 (-)
A/J MGP_AJ_G0008384
miRNA gene Chr18:58904904-58904973 (-)
AKR/J MGP_AKRJ_G0008368
miRNA gene Chr18:60526593-60526662 (-)
BALB/cJ MGP_BALBcJ_G0008369
miRNA gene Chr18:59028928-59028997 (-)
C3H/HeJ MGP_C3HHeJ_G0008314
miRNA gene Chr18:60759606-60759675 (-)
C57BL/6NJ MGP_C57BL6NJ_G0008570
miRNA gene Chr18:63219117-63219186 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0007603
miRNA gene Chr18:58450663-58450732 (-)
CAST/EiJ MGP_CASTEiJ_G0008176
miRNA gene Chr18:60640692-60640761 (-)
CBA/J MGP_CBAJ_G0008280
miRNA gene Chr18:65267569-65267638 (-)
DBA/2J MGP_DBA2J_G0008312
miRNA gene Chr18:58574253-58574322 (-)
FVB/NJ MGP_FVBNJ_G0008334
miRNA gene Chr18:57980338-57980407 (-)
LP/J MGP_LPJ_G0008397
miRNA gene Chr18:61404681-61404750 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0008300
miRNA gene Chr18:66835808-66835877 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0008559
miRNA gene Chr18:60732905-60732974 (-)
PWK/PhJ MGP_PWKPhJ_G0008098
miRNA gene Chr18:58804925-58804994 (-)
SPRET/EiJ MGP_SPRETEiJ_G0007975
miRNA gene Chr18:60960908-60960977 (-)
WSB/EiJ MGP_WSBEiJ_G0008258
miRNA gene Chr18:60586902-60586971 (-)



Homology
more
  • Human Ortholog
    MIR145, microRNA 145
  • Human Ortholog
    MIR145, microRNA 145
    Orthology source: HGNC
  • Synonyms
    miR-145, MIRN145, miRNA145
  • Links
    NCBI Gene ID: 406937

  • Chr Location
    chr5:149430646-149430733 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit vascular smooth muscle hypotrophy, decreased blood pressure, decreased heart weight, and failure to respond normally to carotide artery ligation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 387163 NCBI Gene Model | MGI Sequence Detail 70 C57BL/6J ±  kb
    transcript NR_029557 RefSeq | MGI Sequence Detail 70 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 4
      Primer pair 2
      Other 2
    Other Database
    Links
    less
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 19
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:84907 Lagos-Quintana M, et al., Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002 Apr 30;12(9):735-9
    • Latest
      J:266098 Lam J, et al., miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFbeta signaling. Nat Commun. 2018 Jun 20;9(1):2418

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.
    last database update
    09/10/2019
    MGI 6.14
    The Jackson Laboratory