Mirc32 Complex/Cluster/Region Detail

Summary

• Symbol
  Mirc32
• Name
  microRNA cluster 32, including Mir143 and Mir145a

• Feature Type
  complex/cluster/region
• IDs
  MGI:5447365
• Cluster Members
  Mir145a, Mir143 (2 members)

Location &
Maps

• Sequence Map
  Chr18:61780896-61782329 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 18, Syntenic

Strain
Comparison

• SNPs within 2kb
  52 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  28 phenotypes from 6 alleles in 7 genetic backgrounds
  4 images
  13 phenotype references
  

• All Mutations and Alleles
  8
• Targeted
  8
• Find Mice (IMSR)
  3 strains or lines available

Mice homozygous for a knock-out allele exhibit vascular smooth muscle hypotrophy, decreased blood pressure, decreased heart weight, and failure to respond normally to carotide artery ligation.

Other Database
Links

miRBase

MI0000169, MI0000257

References

• Summaries
  All 16

  Phenotypes 13
• Earliest
  J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
• Latest
  J:322146 Xu R, et al., Identification of the canonical and noncanonical role of miR-143/145 in estrogen-deficient bone loss. Theranostics. 2021;11(11):5491-5510

Mirc32 Cluster contains:

More Data for these features

Member	Feature Type	Location
Mir145a, microRNA 145a	miRNA gene	Chr18:61780896-61780965 (-)
Mir143, microRNA 143	miRNA gene	Chr18:61782267-61782329 (-)