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P2ry6
Gene Detail
Symbol

Name
ID
P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
MGI:2673874
Synonyms
2010204J23Rik, P2Y6
Feature Type
protein coding gene
Genetic Map
Chromosome 7
54.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:100937638-100964391 bp, - strand
From Ensembl annotation of GRCm38

  26754 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14289  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: P2RY6
Protein SuperFamily: P2Y purinoceptors 1/2/3/4/6
Gene Tree: P2ry6

Human
homologs
P2RY6, pyrimidinergic receptor P2Y, G-protein coupled, 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5031
neXtProt AC: NX_Q15077

Human Synonyms: P2Y6

Human Chr (Location): 11q13.5; chr11:73264496-73298625 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit abnormal macrophage, endothelial, and vascular smooth muscle response to UTP and UDP.
 
Interactions
P2ry6 interacts with 93 markers (Mir10a, Mir10b, Mir19a, ...)
Expression
Literature Summary: (1 records)
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000048779 (Evidence)
Entrez Gene 233571 (Evidence)
UniGene 235193
DFCI TC1584271, TC1621417
DoTS DT.101157304, DT.55145640
NIA Mouse Gene Index U028920
Consensus CDS Project CCDS21507.1
International Mouse Phenotyping Consortium Status P2ry6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048779 Ensembl Gene Model | MGI Sequence Detail 26754 C57BL/6J ±  kb
transcript ENSMUST00000060174 Ensembl | MGI Sequence Detail 1938 Not Applicable 
polypeptide ENSMUSP00000055697 Ensembl | MGI Sequence Detail 328 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(255 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001973 P2Y6 purinoceptor
Protein Ontology PR:000001574 P2Y purinoceptor 6
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:197866 Yu W, et al., Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y(6) activation of the phospholipase C/inositol trisphosphate pathway. FASEB J. 2013 May;27(5):1895-903
All references(39)
Other
accession IDs
MGI:1913795

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory