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P2ry6
Gene Detail
 Symbol
Name
ID
P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
MGI:2673874
Synonyms 2010204J23Rik, P2Y6
Feature Type protein coding gene
Genetic Map
Chromosome 7
54.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:100937634-100964366 bp, - strand
From NCBI annotation of GRCm38

  26733 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14289  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: P2Y purinoceptors 1/2/3/4/6
Gene Tree: P2ry6

Human
homologs
Human Homolog P2RY6, pyrimidinergic receptor P2Y, G-protein coupled, 6
NCBI Gene ID 5031
neXtProt AC  NX_Q15077
Human Synonyms  P2Y6
Human Chr (Location)  11q13.5; chr11:73264505-73298625 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal macrophage, endothelial, and vascular smooth muscle response to UTP and UDP.
 
Interactions
P2ry6 interacts with 93 markers (Mir10a, Mir10b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process G-protein coupled receptor signaling pathway, positive regulation of smooth muscle cell migration, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function G-protein coupled purinergic nucleotide receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000048779 (Evidence)
Entrez Gene233571 (Evidence)
UniGene235193
DFCITC1584271, TC1621417
DoTSDT.101157304, DT.55145640
NIA Mouse Gene IndexU028920
Consensus CDS ProjectCCDS21507.1
International Mouse Knockout Project StatusP2ry6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 233571 NCBI Gene Model | MGI Sequence Detail 26733 C57BL/6J ±  kb
transcript NM_183168 RefSeq | MGI Sequence Detail 1917 C57BL/6 
polypeptide Q9ERK9 UniProt | EBI | MGI Sequence Detail 328 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(255 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001973 P2Y6 purinoceptor
Protein Ontology PR:000001574 P2Y purinoceptor 6
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:197866 Yu W, et al., Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y(6) activation of the phospholipase C/inositol trisphosphate pathway. FASEB J. 2013 May;27(5):1895-903
All references(39)
Other
accession IDs
MGI:1913795

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory