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Tcfl5 Gene Detail
Summary
  • Symbol
    Tcfl5
  • Name
    transcription factor-like 5 (basic helix-loop-helix)
  • Synonyms
    FIG beta, Figlb
  • Feature Type
    protein coding gene
  • IDs
    MGI:2672878
    NCBI Gene: 277353
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:180621956-180642702 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 103.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2672878
protein coding gene Chr2:180621956-180642708 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026999
protein coding gene Chr2:187154627-187175241 (-)
A/J MGP_AJ_G0026965
protein coding gene Chr2:179464670-179486167 (-)
AKR/J MGP_AKRJ_G0026935
protein coding gene Chr2:184846398-184867318 (-)
BALB/cJ MGP_BALBcJ_G0026974
protein coding gene Chr2:179928706-179949337 (-)
C3H/HeJ MGP_C3HHeJ_G0026715
protein coding gene Chr2:185196645-185218205 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027420
protein coding gene Chr2:192556641-192577330 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024785
protein coding gene Chr2:170155611-170176565 (-)
CAST/EiJ MGP_CASTEiJ_G0026174
protein coding gene Chr2:183437454-183459098 (-)
CBA/J MGP_CBAJ_G0026692
protein coding gene Chr2:199558230-199578828 (-)
DBA/2J MGP_DBA2J_G0026830
protein coding gene Chr2:178562241-178583142 (-)
FVB/NJ MGP_FVBNJ_G0026796
protein coding gene Chr2:177177653-177198295 (-)
LP/J MGP_LPJ_G0026931
protein coding gene Chr2:187164363-187185182 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026815
protein coding gene Chr2:202156464-202177042 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027479
protein coding gene Chr2:184800902-184822869 (-)
PWK/PhJ MGP_PWKPhJ_G0025910
protein coding gene Chr2:176074181-176095074 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025710
protein coding gene Chr2:181297806-181320330 (-)
WSB/EiJ MGP_WSBEiJ_G0026246
protein coding gene Chr2:185785709-185807293 (-)



Homology
more
  • Human Ortholog
    TCFL5, transcription factor like 5
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TCFL5, transcription factor like 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHe82, CHA, E2BP-1, Figlb, SOSF1
  • Links
    NCBI Gene ID: 10732
    neXtProt AC: NX_Q9UL49
    UniProt: Q9UL49

  • Chr Location
    20q13.33; chr20:62841014-62861763 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 277353 NCBI Gene Model | MGI Sequence Detail 20747 C57BL/6J ±  kb
transcript NM_178254 RefSeq | MGI Sequence Detail 2237 Not Specified  
polypeptide NP_001347264 RefSeq | MGI Sequence Detail 490 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR036638 Helix-loop-helix DNA-binding domain superfamily
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR039583 Transcription factor-like 5 protein
Molecular
Reagents
less
  • All nucleic 13
    cDNA 11
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2139262
References
more
  • Summaries
    All 29
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/04/2019
MGI 6.14
The Jackson Laboratory