Nrde2 MGI Mouse Gene Detail - MGI:2670969 - nrde-2 necessary for RNA interference, domain containing

Symbol

Nrde2
Name

nrde-2 necessary for RNA interference, domain containing
Synonyms

6720454P05Rik, BC002230

Feature Type

protein coding gene
IDs

MGI:2670969
NCBI Gene: 217827
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:100091711-100125912 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 50.43 cM
Mapping Data

3 experiments

SNPs within 2kb

141 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2670969	protein coding gene	Chr12:100091709-100126981 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020016	protein coding gene	Chr12:101586281-101622162 (-)
A/J	MGP_AJ_G0019971	protein coding gene	Chr12:97770803-97804965 (-)
AKR/J	MGP_AKRJ_G0019947	protein coding gene	Chr12:100410349-100444528 (-)
BALB/cJ	MGP_BALBcJ_G0019957	protein coding gene	Chr12:98114167-98148342 (-)
C3H/HeJ	MGP_C3HHeJ_G0019759	protein coding gene	Chr12:100953170-100989314 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020406	protein coding gene	Chr12:104723240-104760900 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018020	protein coding gene	Chr12:94742599-94777672 (-)
CAST/EiJ	MGP_CASTEiJ_G0019305	protein coding gene	Chr12:96064569-96101193 (-)
CBA/J	MGP_CBAJ_G0019731	protein coding gene	Chr12:108613278-108649077 (-)
DBA/2J	MGP_DBA2J_G0019842	protein coding gene	Chr12:97204907-97239277 (-)
FVB/NJ	MGP_FVBNJ_G0019831	protein coding gene	Chr12:95923799-95958415 (-)
LP/J	MGP_LPJ_G0019918	protein coding gene	Chr12:101428041-101463418 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019873	protein coding gene	Chr12:112206735-112241312 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020435	protein coding gene	Chr12:99984459-100019627 (-)
PWK/PhJ	MGP_PWKPhJ_G0019069	protein coding gene	Chr12:91837286-91872591 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018865	protein coding gene	Chr12:94161500-94196866 (-)
WSB/EiJ	MGP_WSBEiJ_G0019359	protein coding gene	Chr12:100835706-100871235 (-)

Human Ortholog

NRDE2, NRDE-2, necessary for RNA interference, domain containing

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NRDE2, NRDE-2, necessary for RNA interference, domain containing
Synonyms

C14orf102
Links

HGNC:20186

NCBI Gene ID: 55051

neXtProt AC: NX_Q9H7Z3

UniProt: Q9H7Z3
Chr Location

14q32.11; chr14:90267860-90331969 (-) GRCh38

MGI Vertebrate Homology

Nrde2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NRDE2
Gene Tree

Nrde2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

10
Targeted

4
Genomic Mutations

1 involving Nrde2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

47 strains or lines available

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All GO Annotations

23
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

78

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nrde2

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All Sequences

53
RefSeq

11
UniProt

2
CCDS

CCDS70414.1

Ensembl

ENSMUSG00000021179 (Evidence)
NCBI Gene

217827

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021179	Ensembl Gene Model \| MGI Sequence Detail	34202	C57BL/6J	± kb
transcript	ENSMUST00000021596	Ensembl \| MGI Sequence Detail	3718	Not Applicable
polypeptide	ENSMUSP00000021596	Ensembl \| MGI Sequence Detail	1172	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000060092 nuclear exosome regulator NRDE2

(term hierarchy)
InterPro Domains

IPR003107 HAT (Half-A-TPR) repeat

IPR013633 siRNA-mediated silencing protein NRDE-2

IPR011990 Tetratricopeptide-like helical domain superfamily

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All nucleic 79

cDNA 79

Microarray probesets 2

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MGI:2443747

Summaries

All 39

Gene Ontology 5

Phenotypes 13
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194

TSS for Nrde2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr117314	Chr12:100125860-100125931 (-)	16 bp
Tssr3919	Chr12:100100716-100100729 (-)	25,189 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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