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Tent5a Gene Detail
Summary
  • Symbol
    Tent5a
  • Name
    terminal nucleotidyltransferase 5A
  • Synonyms
    BAP014, D930050G01Rik, Fam46a
  • Feature Type
    protein coding gene
  • IDs
    MGI:2670964
    NCBI Gene: 212943
  • Gene Overview
    MyGene.info: TENT5A
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:85320439-85327150 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 46.04 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2670964
protein coding gene Chr9:85320439-85327348 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035091
protein coding gene Chr9:86077830-86084731 (-)
A/J MGP_AJ_G0035072
protein coding gene Chr9:83087125-83094026 (-)
AKR/J MGP_AKRJ_G0035000
protein coding gene Chr9:85050779-85057680 (-)
BALB/cJ MGP_BALBcJ_G0035060
protein coding gene Chr9:82734068-82740968 (-)
C3H/HeJ MGP_C3HHeJ_G0034772
protein coding gene Chr9:85531035-85537935 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035584
protein coding gene Chr9:88408992-88415895 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032491
protein coding gene Chr9:81908124-81915022 (-)
CAST/EiJ MGP_CASTEiJ_G0034090
protein coding gene Chr9:85949255-86003151 (-)
CBA/J MGP_CBAJ_G0034745
protein coding gene Chr9:91605760-91612667 (-)
DBA/2J MGP_DBA2J_G0034903
protein coding gene Chr9:82663178-82670082 (-)
FVB/NJ MGP_FVBNJ_G0034846
protein coding gene Chr9:81776549-81783449 (-)
LP/J MGP_LPJ_G0034984
protein coding gene Chr9:86294880-86301781 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034888
protein coding gene Chr9:93173379-93180279 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035604
protein coding gene Chr9:85185801-85192701 (-)
PWK/PhJ MGP_PWKPhJ_G0033794
protein coding gene Chr9:82799956-82848522 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033630
protein coding gene Chr9:85327431-85376990 (-)
WSB/EiJ MGP_WSBEiJ_G0034207
protein coding gene Chr9:85206470-85214451 (-)



Homology
more
  • Human Ortholog
    TENT5A, terminal nucleotidyltransferase 5A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TENT5A, terminal nucleotidyltransferase 5A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C6orf37, FAM46A, OI18, XTP11
  • Links
    NCBI Gene ID: 55603
    neXtProt AC: NX_Q96IP4
    UniProt: Q96IP4

  • Chr Location
    6q14.1; chr6:81745730-81752711 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 23032
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TENT5A
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 1 allele in 1 genetic background
    3 images
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for an ENU-induced allele show partial lethality, high alkaline phosphatase (ALP) activity, short stature, and limb, long bone, rib, pelvis and skull anomalies, with absent trabeculae and reduced cortical thickness in long bones. Heterozygotes show high ALP activity but no other defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 212943 NCBI Gene Model | MGI Sequence Detail 6712 C57BL/6J ±  kb
    transcript NM_001160378 RefSeq | MGI Sequence Detail 5479 C57BL/6  
    polypeptide NP_001153850 RefSeq | MGI Sequence Detail 447 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR012937 Terminal nucleotidyltransferase
    Molecular
    Reagents
    less
    • All nucleic 64
      Genomic 1
      cDNA 61
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2443837, MGI:5425501
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 3
      Gene Ontology 1
      Phenotypes 5
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:230816 Diener S, et al., Exome sequencing identifies a nonsense mutation in Fam46a associated with bone abnormalities in a new mouse model for skeletal dysplasia. Mamm Genome. 2016 Apr;27(3-4):111-21

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory