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P2rx2
Gene Detail
 Symbol
Name
ID
P2rx2
purinergic receptor P2X, ligand-gated ion channel, 2
MGI:2665170
Synonyms P2x2, P2X2a
Feature Type protein coding gene
Genetic Map
Chromosome 5
53.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:110339812-110343035 bp, - strand
From NCBI annotation of GRCm38

  3224 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:14251  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: P2X purinoceptor
Gene Tree: P2rx2

Human
homologs
Human Homolog P2RX2, purinergic receptor P2X, ligand-gated ion channel, 2
NCBI Gene ID 22953
neXtProt AC  NX_Q9UBL9
Human Synonyms  DFNA41, P2X2
Human Chr (Location)  12q24.33; chr12:132618780-132622386 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human P2RX2
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice are viable and show no gross pathology. Mice show abnormal ventilatory and electrophysiological responses to hypoxia.
 
Interactions
P2rx2 interacts with 62 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (64 annotations)
Process behavioral response to pain, cation transport, ...
Component apical plasma membrane, cell surface, ...
Function ATP binding, cadmium ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (16)    Tissues (4)    Images (12)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 14
RT-PCR 2
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000029503 (Evidence)
Entrez Gene231602 (Evidence)
UniGene55948
DFCITC1584419
DoTSDT.101372703, DT.101372705, DT.110701105, DT.110701107, DT.60109410, DT.94270942
NIA Mouse Gene IndexU026556
Consensus CDS ProjectCCDS51607.1, CCDS51608.1
International Mouse Knockout Project StatusP2rx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 231602 NCBI Gene Model | MGI Sequence Detail 3224 C57BL/6J ±  kb
transcript NM_153400 RefSeq | MGI Sequence Detail 1919 C57BL/6 
polypeptide Q8K3P1 UniProt | EBI | MGI Sequence Detail 485 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(14) UniProt(2)
Polymorphisms SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003045 P2X2 purinoceptor
InterPro IPR001429 P2X purinoreceptor
InterPro IPR027309 P2X purinoreceptor extracellular domain
Protein Ontology PR:000012189 P2X purinoceptor 2
Graphical View of Protein Domain Structure
References (Earliest) J:86890 Rong W, et al., Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia. J Neurosci. 2003 Dec 10;23(36):11315-21
(Latest) J:196658 Housley GD, et al., ATP-gated ion channels mediate adaptation to elevated sound levels. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7494-9
All references(46)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory