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P2rx2 Gene Detail
Summary
  • Symbol
    P2rx2
  • Name
    purinergic receptor P2X, ligand-gated ion channel, 2
  • Synonyms
    P2x2, P2X2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:2665170
    NCBI Gene: 231602
  • Gene Overview
    MyGene.info: P2RX2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:110339812-110343212 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3401 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 53.49 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    P2RX2, purinergic receptor P2X 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    P2RX2, purinergic receptor P2X 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DFNA41, P2X2
  • Links
    NCBI Gene ID: 22953
    neXtProt AC: NX_Q9UBL9
    UniProt: Q9UBL9

  • Chr Location
    12q24.33; chr12:132618780-132623678 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human P2RX2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable and show no gross pathology. Mice show abnormal ventilatory and electrophysiological responses to hypoxia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000054126 VEGA Gene Model | MGI Sequence Detail 3401 C57BL/6J ±  kb
    transcript OTTMUST00000134471 VEGA | MGI Sequence Detail 1895 Not Applicable  
    polypeptide OTTMUSP00000071297 VEGA | MGI Sequence Detail 497 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      45 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 4
      Gene Ontology 15
      Phenotypes 22
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:244957 El Shahawy M, et al., Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid. PLoS Genet. 2017 Jul;13(7):e1006914

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory