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P2rx2 Gene Detail
Summary
  • Symbol
    P2rx2
  • Name
    purinergic receptor P2X, ligand-gated ion channel, 2
  • Synonyms
    P2x2, P2X2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:2665170
    NCBI Gene: 231602
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:110487678-110491078 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 53.49 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2665170
 protein coding gene Chr5:110487678-110491186 (-)
129S1/SvImJ ENSMUSG00200021806
 protein coding gene Chr5:104251244-104254644 (-)
A/J ENSMUSG00195033019
 protein coding gene Chr5:103733208-103736608 (-)
AKR/J ENSMUSG00220049509
 protein coding gene Chr5:103263649-103267049 (-)
BALB/cJ ENSMUSG00180041839
 protein coding gene Chr5:103884938-103888338 (-)
C3H/HeJ ENSMUSG00175038564
 protein coding gene Chr5:105870348-105873748 (-)
C57BL/6NJ ENSMUSG00215026856
 protein coding gene Chr5:103884897-103888297 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027544
 protein coding gene Chr5:103248546-103251927 (-)
CAST/EiJ ENSTCUG00005028897
 protein coding gene Chr5:103065558-103068957 (-)
CBA/J ENSMUSG00210038836
 protein coding gene Chr5:104622476-104625876 (-)
DBA/2J ENSMUSG00185047448
 protein coding gene Chr5:107647819-107651219 (-)
FVB/NJ ENSMUSG00205050856
 protein coding gene Chr5:103522307-103525707 (-)
JF1/MsJ ENSUMUG00000005787
 protein coding gene Chr5:110498178-110501578 (-)
LP/J ENSMUSG00230046634
 protein coding gene Chr5:111789715-111793115 (-)
NOD/ShiLtJ ENSMUSG00190046874
 protein coding gene Chr5:103558847-103562247 (-)
NZO/HlLtJ ENSMUSG00225025163
 protein coding gene Chr5:119411571-119414971 (-)
PWK/PhJ ENSLUMG00010029883
 protein coding gene Chr5:102412286-102415686 (-)
SPRET/EiJ ENSMSPG00010039555
 protein coding gene Chr5:105656134-105659528 (-)
WSB/EiJ ENSIUOG00005036692
 protein coding gene Chr5:106262144-106265544 (-)



Homology
more
  • Human Ortholog
    P2RX2, purinergic receptor P2X 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    P2RX2, purinergic receptor P2X 2
  • Synonyms
    DFNA41, P2X2
  • Links
    NCBI Gene ID: 22953
    UniProt: Q9UBL9

  • Chr Location
    12q24.33; chr12:132618776-132622388 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with P2rx2 mouse models; 1 with human P2RX2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable and show no gross pathology but show abnormal ventilatory and electrophysiological responses to hypoxia. Mice heterozygous for a p.V61L mutation experience progressive sensorineural hearing loss and increased sensitivity to thermal pain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    84
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    613
  • Tissues
    5
  • cDNA Data
    6
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029503 Ensembl Gene Model | MGI Sequence Detail 3401 C57BL/6J ±  kb
    transcript ENSMUST00000058016 Ensembl | MGI Sequence Detail 1895 Not Applicable  
    polypeptide ENSMUSP00000054233 Ensembl | MGI Sequence Detail 497 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 20
      Phenotypes 42
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:375309 Darcey TS, et al., Reflex regulation of respiration and heart rate by inhaled activators of vagal bronchopulmonary afferents. J Neurophysiol. 2025 Nov 1;134(5):1540-1556
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory