About   Help   FAQ
Synm Gene Detail
Summary
  • Symbol
    Synm
  • Name
    synemin, intermediate filament protein
  • Synonyms
    4930412K21Rik, Dmn, Synemin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2661187
    NCBI Gene: 233335
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:67730161-67759742 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 37.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    386 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2661187
protein coding gene Chr7:67730160-67759742 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032361
protein coding gene Chr7:69001707-69034822 (-)
A/J MGP_AJ_G0032340
protein coding gene Chr7:67574243-67604123 (-)
AKR/J MGP_AKRJ_G0032276
protein coding gene Chr7:69007211-69038638 (-)
BALB/cJ MGP_BALBcJ_G0032352
protein coding gene Chr7:67311131-67340592 (-)
C3H/HeJ MGP_C3HHeJ_G0032065
protein coding gene Chr7:69693745-69725518 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032844
protein coding gene Chr7:71951729-71984890 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029852
protein coding gene Chr7:70432505-70463141 (-)
CAST/EiJ MGP_CASTEiJ_G0031393
protein coding gene Chr7:60384600-60414121 (-)
CBA/J MGP_CBAJ_G0032031
protein coding gene Chr7:74208008-74239814 (-)
DBA/2J MGP_DBA2J_G0032186
protein coding gene Chr7:66290754-66320601 (-)
FVB/NJ MGP_FVBNJ_G0032141
protein coding gene Chr7:66407639-66437730 (-)
LP/J MGP_LPJ_G0032267
protein coding gene Chr7:70226919-70258393 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032178
protein coding gene Chr7:74415123-74447595 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032862
protein coding gene Chr7:68370850-68406018 (-)
PWK/PhJ MGP_PWKPhJ_G0031113
protein coding gene Chr7:59345303-59375027 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030954
protein coding gene Chr7:55409778-55444119 (-)
WSB/EiJ MGP_WSBEiJ_G0031511
protein coding gene Chr7:68710295-68741918 (-)



Homology
more
  • Human Ortholog
    SYNM, synemin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SYNM, synemin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DMN, SYN
  • Links
    NCBI Gene ID: 23336
    neXtProt AC: NX_O15061
    UniProt: O15061

  • Chr Location
    15q26.3; chr15:99105069-99136586 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9081
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SYNM
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 1 allele in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a mild skeletal muscle phenotype characterized by abnormal muscle fiber morphology and increased sarcolemmal deformability and susceptibility to injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233335 NCBI Gene Model | MGI Sequence Detail 29582 C57BL/6J ±  kb
    transcript NM_201639 RefSeq | MGI Sequence Detail 7866 C57BL/6  
    polypeptide Q70IV5 UniProt | EBI | MGI Sequence Detail 1561 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 37
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1921189, MGI:2142061
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:257039 Garcia-Pelagio KP, et al., Absence of synemin in mice causes structural and functional abnormalities in heart. J Mol Cell Cardiol. 2018 Jan;114:354-363

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory