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Opalin Gene Detail
Summary
  • Symbol
    Opalin
  • Name
    oligodendrocytic myelin paranodal and inner loop protein
  • Synonyms
    Tmem10, Tmp10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2657025
    NCBI Gene: 226115
  • Gene Overview
    MyGene.info: OPALIN
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:41063420-41077113 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 34.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2657025
protein coding gene Chr19:41062474-41077113 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025119
protein coding gene Chr19:40321782-40337796 (-)
A/J MGP_AJ_G0025096
protein coding gene Chr19:38384108-38398907 (-)
AKR/J MGP_AKRJ_G0025064
protein coding gene Chr19:39650416-39666479 (-)
BALB/cJ MGP_BALBcJ_G0025090
protein coding gene Chr19:38434776-38449445 (-)
C3H/HeJ MGP_C3HHeJ_G0024850
protein coding gene Chr19:39792882-39808066 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025534
protein coding gene Chr19:41401548-41417015 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022947
protein coding gene Chr19:37747601-37760912 (-)
CAST/EiJ MGP_CASTEiJ_G0024315
protein coding gene Chr19:39427291-39443928 (-)
CBA/J MGP_CBAJ_G0024830
protein coding gene Chr19:43414116-43432097 (-)
DBA/2J MGP_DBA2J_G0024962
protein coding gene Chr19:38246160-38260745 (-)
FVB/NJ MGP_FVBNJ_G0024923
protein coding gene Chr19:38000883-38015297 (-)
LP/J MGP_LPJ_G0025048
protein coding gene Chr19:40338361-40353415 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024954
protein coding gene Chr19:43072797-43092498 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025591
protein coding gene Chr19:39677363-39691710 (-)
PWK/PhJ MGP_PWKPhJ_G0024065
protein coding gene Chr19:38094511-38110103 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023868
protein coding gene Chr19:38417831-38432878 (-)
WSB/EiJ MGP_WSBEiJ_G0024385
protein coding gene Chr19:39842943-39860405 (-)



Homology
more
  • Human Ortholog
    OPALIN, oligodendrocytic myelin paranodal and inner loop protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    OPALIN, oligodendrocytic myelin paranodal and inner loop protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HTMP10, TMEM10, TMP10
  • Links
    NCBI Gene ID: 93377
    neXtProt AC: NX_Q96PE5
    UniProt: Q96PE5

  • Chr Location
    10q24.1; chr10:96343216-96359365 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 226115 NCBI Gene Model | MGI Sequence Detail 13694 C57BL/6J ±  kb
transcript NM_153520 RefSeq | MGI Sequence Detail 892 Not Specified  
polypeptide Q7M750 UniProt | EBI | MGI Sequence Detail 143 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 6
    Primer pair 3

    Microarray probesets 1
References
more
  • Summaries
    All 26
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 1
  • Earliest
    J:74484 Nobile C, et al., Identification and characterization of a novel human brain-specific gene, homologous to S. scrofa tmp83.5, in the chromosome 10q24 critical region for temporal lobe epilepsy and spastic paraplegia. Gene. 2002 Jan 9;282(1-2):87-94
  • Latest
    J:235473 Moyon S, et al., Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage. Cell Rep. 2016 Apr 26;15(4):748-760

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory