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Opalin Gene Detail
Summary
  • Symbol
    Opalin
  • Name
    oligodendrocytic myelin paranodal and inner loop protein
  • Synonyms
    Tmem10, Tmp10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2657025
    NCBI Gene: 226115
  • Gene Overview
    MyGene.info: OPALIN
Location & Maps
more
  • Sequence Map
    Chr19:41063420-41077113 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13694 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 34.36 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    OPALIN, oligodendrocytic myelin paranodal and inner loop protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    OPALIN, oligodendrocytic myelin paranodal and inner loop protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HTMP10, TMEM10, TMP10
  • Links
    NCBI Gene ID: 93377
    neXtProt AC: NX_Q96PE5

  • Chr Location
    10q23-q24; chr10:96343216-96359365 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 226115 NCBI Gene Model | MGI Sequence Detail 13694 C57BL/6J ±  kb
transcript NM_153520 RefSeq | MGI Sequence Detail 892 Not Specified  
polypeptide Q7M750 UniProt | EBI | MGI Sequence Detail 143 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    14 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 5
    Primer pair 2

    Microarray probesets 1
References
more
  • Summaries
    All 21
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 1
  • Earliest
    J:74484 Nobile C, et al., Identification and characterization of a novel human brain-specific gene, homologous to S. scrofa tmp83.5, in the chromosome 10q24 critical region for temporal lobe epilepsy and spastic paraplegia. Gene. 2002 Jan 9;282(1-2):87-94
  • Latest
    J:217386 Zou Y, et al., Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain. J Neurosci. 2014 Nov 19;34(47):15764-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory