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Padi6
Gene Detail
Symbol

Name
ID
Padi6
peptidyl arginine deiminase, type VI
MGI:2655198
Synonyms
ePAD, Pad6, Padi5
Feature Type
protein coding gene
Genetic Map
Chromosome 4
72.26 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:140727355-140742643 bp, - strand
From VEGA annotation of GRCm38

  15289 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: PADI6
Protein SuperFamily: protein-arginine deiminase
Gene Tree: Padi6

Human
homologs
PADI6, peptidyl arginine deiminase, type VI
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 353238
neXtProt AC: NX_Q6TGC4

Human Synonyms: hPADVI

Human Chr (Location): 1p36.13; chr1:17372196-17401699 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Padi6 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit altered oocyte cytoplasmic structures that lead to a failure of zygotes to progress beyond the 2 cell stage and female infertility.
 
Interactions
Padi6 interacts with 34 markers (Mir18, Mir18b, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cellular protein localization, cytoplasm organization, ...
Component cytoplasm, intermediate filament cytoskeleton, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (158)    Tissues (131)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 111
RT-PCR 47
cDNA source data(45)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(45) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000010035 (Evidence)
Ensembl Gene Model ENSMUSG00000040935 (Evidence)
Entrez Gene 242726 (Evidence)
UniGene 271661
DFCI TC1577677
DoTS DT.97357983
NIA Mouse Gene Index U025712
EC 3.5.3.15
Consensus CDS Project CCDS38936.1
International Mouse Phenotyping Consortium Status Padi6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010035 VEGA Gene Model | MGI Sequence Detail 15289 C57BL/6J ±  kb
transcript OTTMUST00000023354 VEGA | MGI Sequence Detail 2333 Not Applicable 
polypeptide OTTMUSP00000010677 VEGA | MGI Sequence Detail 682 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(188 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008972 Cupredoxin
InterPro IPR004303 Protein-arginine deiminase
InterPro IPR013530 Protein-arginine deiminase, C-terminal
InterPro IPR013733 Protein-arginine deiminase (PAD), central domain
InterPro IPR013732 Protein-arginine deiminase (PAD) N-terminal
Protein Ontology PR:000012223 protein-arginine deiminase type-6
References
(Earliest) J:82688 Wright PW, et al., ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets. Dev Biol. 2003 Apr 1;256(1):73-88
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory