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Padi6 Gene Detail
Summary
  • Symbol
    Padi6
  • Name
    peptidyl arginine deiminase, type VI
  • Synonyms
    ePAD, Pad6, Padi5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2655198
    NCBI Gene: 242726
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:140727355-140742643 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15289 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 72.26 cM, cytoband E1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PADI6, peptidyl arginine deiminase 6
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PADI6, peptidyl arginine deiminase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hPADVI, PREMBL2
  • Links
    NCBI Gene ID: 353238
    neXtProt AC: NX_Q6TGC4
    UniProt: Q6TGC4

  • Chr Location
    1p36.13; chr1:17372196-17401699 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit altered oocyte cytoplasmic structures that lead to a failure of zygotes to progress beyond the 2 cell stage and female infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000010035 VEGA Gene Model | MGI Sequence Detail 15289 C57BL/6J ±  kb
    transcript OTTMUST00000023354 VEGA | MGI Sequence Detail 2333 Not Applicable  
    polypeptide OTTMUSP00000010677 VEGA | MGI Sequence Detail 682 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      184 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 45
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:82688 Wright PW, et al., ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets. Dev Biol. 2003 Apr 1;256(1):73-88
    • Latest
      J:245369 Yu C, et al., BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes. Nat Struct Mol Biol. 2016 May;23(5):387-94

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory