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Padi6 Gene Detail
Summary
  • Symbol
    Padi6
  • Name
    peptidyl arginine deiminase, type VI
  • Synonyms
    ePAD, Pad6, Padi5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2655198
    NCBI Gene: 242726
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:140727355-140742643 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 72.26 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2655198
protein coding gene Chr4:140727355-140742643 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029028
protein coding gene Chr4:143692727-143712493 (-)
A/J MGP_AJ_G0028987
protein coding gene Chr4:137474938-137490117 (-)
AKR/J MGP_AKRJ_G0028939
protein coding gene Chr4:141448490-141463216 (-)
BALB/cJ MGP_BALBcJ_G0029011
protein coding gene Chr4:138169695-138184867 (-)
C3H/HeJ MGP_C3HHeJ_G0028725
protein coding gene Chr4:141831321-141846564 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029452
protein coding gene Chr4:148745824-148762193 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026723
protein coding gene Chr4:130410979-130426135 (-)
CAST/EiJ MGP_CASTEiJ_G0028157
protein coding gene Chr4:140067300-140083778 (-)
CBA/J MGP_CBAJ_G0028689
protein coding gene Chr4:152989725-153005120 (-)
DBA/2J MGP_DBA2J_G0028839
protein coding gene Chr4:137876896-137892003 (-)
FVB/NJ MGP_FVBNJ_G0028806
protein coding gene Chr4:136969940-136985151 (-)
LP/J MGP_LPJ_G0028938
protein coding gene Chr4:143733476-143749625 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028832
protein coding gene Chr4:156912519-156929411 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029490
protein coding gene Chr4:141973519-141989659 (-)
PWK/PhJ MGP_PWKPhJ_G0027878
protein coding gene Chr4:134751383-134766704 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027703
protein coding gene Chr4:137790754-137811273 (-)
WSB/EiJ MGP_WSBEiJ_G0028235
protein coding gene Chr4:142256081-142274199 (-)



Homology
more
  • Human Ortholog
    PADI6, peptidyl arginine deiminase 6
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PADI6, peptidyl arginine deiminase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hPADVI, PREMBL2
  • Links
    NCBI Gene ID: 353238
    neXtProt AC: NX_Q6TGC4
    UniProt: Q6TGC4

  • Chr Location
    1p36.13; chr1:17372196-17401699 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit altered oocyte cytoplasmic structures that lead to a failure of zygotes to progress beyond the 2 cell stage and female infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 242726 NCBI Gene Model | MGI Sequence Detail 15289 C57BL/6J ±  kb
    transcript NM_153106 RefSeq | MGI Sequence Detail 2333 C57BL/6  
    polypeptide Q8K3V4 UniProt | EBI | MGI Sequence Detail 682 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 46
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 10
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:82688 Wright PW, et al., ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets. Dev Biol. 2003 Apr 1;256(1):73-88
    • Latest
      J:282460 Rong Y, et al., ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation. Nucleic Acids Res. 2019 Dec 2;47(21):11387-11402

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    02/18/2020
    MGI 6.14
    The Jackson Laboratory