Sequence Detail

ID/Version

Q8K3V4 Q75WC6 (UniProt | EBI)

Last sequence update: 2004-12-21
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Inactive protein-arginine deiminase type-6 {ECO:0000305};AltName: Full=Arginine deiminase-like protein;AltName: Full=Egg and embryo abundant PAD {ECO:0000303|PubMed:16137333}; Short=ePAD {ECO:0000303|PubMed:16137333};AltName: Full=P7

Provider

SWISS-PROT

Sequence

Polypeptide 682 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Padi6	peptidyl arginine deiminase, type VI	42	107	3	13

Sequence references in MGI

J:82688 Wright PW, et al., ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets. Dev Biol. 2003 Apr 1;256(1):73-88
J:90605 Chavanas S, et al., Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6. Gene. 2004 Apr 14;330:19-27
J:138573 Yurttas P, et al., Role for PADI6 and the cytoplasmic lattices in ribosomal storage in oocytes and translational control in the early mouse embryo. Development. 2008 Aug;135(15):2627-36
J:138684 Esposito G, et al., Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and female fertility. Mol Cell Endocrinol. 2007 Jul 15;273(1-2):25-31
J:170413 Kan R, et al., Regulation of mouse oocyte microtubule and organelle dynamics by PADI6 and the cytoplasmic lattices. Dev Biol. 2011 Feb 15;350(2):311-22
J:302576 Liu M, et al., Peptidylarginine deiminase (PAD) is a mouse cortical granule protein that plays a role in preimplantation embryonic development. Reprod Biol Endocrinol. 2005 Sep 1;3:42
J:342673 Jentoft IMA, et al., Mammalian oocytes store proteins for the early embryo on cytoplasmic lattices. Cell. 2023 Oct 30;
J:346894 Giaccari C, et al., A maternal-effect Padi6 variant causes nuclear and cytoplasmic abnormalities in oocytes, as well as failure of epigenetic reprogramming and zygotic genome activation in embryos. Genes Dev. 2024 Mar 22;38(3-4):131-150
J:362017 Liu X, et al., Role for PADI6 in securing the mRNA-MSY2 complex to the oocyte cytoplasmic lattices. Cell Cycle. 2017 Feb 16;16(4):360-366