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Otud7b
Gene Detail
Symbol

Name
ID
Otud7b
OTU domain containing 7B
MGI:2654703
Synonyms
2900060B22Rik, 4930463P07Rik, Za20d1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
41.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:96104527-96161129 bp, + strand
From VEGA annotation of GRCm38

  56603 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10624  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: OTUD7B
Gene Tree: Otud7b

Human
homologs
OTUD7B, OTU deubiquitinase 7B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 56957
neXtProt AC: NX_Q6GQQ9

Human Synonyms: CEZANNE, ZA20D1

Human Chr (Location): 1q21.2; chr1:149940330-150010772 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(17) Targeted(4)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit decreased body weight, tertiary lymphoid hyperplasia, increased stimulated B cell proliferation and survival and decreased susceptibility to C. rodentium infection.
 
Interactions
Otud7b interacts with 446 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process immune system process, mucosal immune response, ...
Component cytoplasm, nucleus
Function cysteine-type peptidase activity, DNA binding, ...
External Resources: FuncBase
Expression
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase otud7b ; ZFIN otud7b    NEW 
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000021893 (Evidence)
Ensembl Gene Model ENSMUSG00000038495 (Evidence)
Entrez Gene 229603 (Evidence)
DFCI TC1617003, TC1631966, TC1633039, TC1641350, TC1678865
NIA Mouse Gene Index U003587
EC 3.4.19.12
Consensus CDS Project CCDS17629.1
International Mouse Phenotyping Consortium Status Otud7b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021893 VEGA Gene Model | MGI Sequence Detail 56603 C57BL/6J ±  kb
transcript OTTMUST00000051991 VEGA | MGI Sequence Detail 8101 Not Applicable 
polypeptide OTTMUSP00000024551 VEGA | MGI Sequence Detail 840 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(16) UniProt(3)
Polymorphisms
SNPs within 2kb(248 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003323 Ovarian tumour, otubain
InterPro IPR009060 UBA-like
InterPro IPR002653 Zinc finger, A20-type
Protein Ontology PR:000012084 OTU domain-containing protein 7B
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:217543 Bremm A, et al., Cezanne (OTUD7B) regulates HIF-1alpha homeostasis in a proteasome-independent manner. EMBO Rep. 2014 Dec;15(12):1268-77
All references(44)
Other
accession IDs
MGI:1920219, MGI:1922172, MGI:2139730

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory