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Otud7b Gene Detail
Summary
  • Symbol
    Otud7b
  • Name
    OTU domain containing 7B
  • Synonyms
    2900060B22Rik, 4930463P07Rik, Za20d1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2654703
    NCBI Gene: 229603
  • Gene Overview
    MyGene.info: OTUD7B
Location & Maps
more
  • Sequence Map
    Chr3:96104527-96161129 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      56603 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 41.65 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    OTUD7B, OTU deubiquitinase 7B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    OTUD7B, OTU deubiquitinase 7B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CEZANNE, ZA20D1
  • Links
    NCBI Gene ID: 56957
    neXtProt AC: NX_Q6GQQ9

  • Chr Location
    1q21.2; chr1:149940330-150010772 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 4 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    1
  • Gene trapped
    17
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Otud7b
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a knock-out allele exhibit decreased body weight, tertiary lymphoid hyperplasia, increased stimulated B cell proliferation and survival and decreased susceptibility to C. rodentium infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021893 VEGA Gene Model | MGI Sequence Detail 56603 C57BL/6J ±  kb
transcript OTTMUST00000051992 VEGA | MGI Sequence Detail 8046 Not Applicable  
polypeptide OTTMUSP00000024552 VEGA | MGI Sequence Detail 840 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    248 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 6
Other
Accession IDs
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MGI:1920219, MGI:1922172, MGI:2139730
References
more
  • Summaries
    All 46
    Gene Ontology 9
    Phenotypes 18
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:232930 Hu H, et al., Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination. J Exp Med. 2016 Mar 7;213(3):399-414

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory