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Otud7b Gene Detail
Summary
  • Symbol
    Otud7b
  • Name
    OTU domain containing 7B
  • Synonyms
    2900060B22Rik, 4930463P07Rik, Za20d1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2654703
    NCBI Gene: 229603
  • Gene Overview
    MyGene.info: OTUD7B
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:96104527-96161129 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 41.65 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    248 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2654703
protein coding gene Chr3:96104510-96161129 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027604
protein coding gene Chr3:96914991-96972023 (+)
A/J MGP_AJ_G0027563
protein coding gene Chr3:93867664-93928050 (+)
AKR/J MGP_AKRJ_G0027530
protein coding gene Chr3:96066473-96123040 (+)
BALB/cJ MGP_BALBcJ_G0027575
protein coding gene Chr3:93648508-93705439 (+)
C3H/HeJ MGP_C3HHeJ_G0027308
protein coding gene Chr3:96356134-96412938 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028023
protein coding gene Chr3:100462263-100518797 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025363
protein coding gene Chr3:90193226-90251498 (+)
CAST/EiJ MGP_CASTEiJ_G0026758
protein coding gene Chr3:95642229-95698937 (+)
CBA/J MGP_CBAJ_G0027285
protein coding gene Chr3:104148507-104207751 (+)
DBA/2J MGP_DBA2J_G0027424
protein coding gene Chr3:93161709-93218189 (+)
FVB/NJ MGP_FVBNJ_G0027395
protein coding gene Chr3:91237393-91294108 (+)
LP/J MGP_LPJ_G0027533
protein coding gene Chr3:98218721-98276714 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027422
protein coding gene Chr3:110246482-110309778 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028077
protein coding gene Chr3:95700846-95757596 (+)
PWK/PhJ MGP_PWKPhJ_G0026486
protein coding gene Chr3:93057222-93114545 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026307
protein coding gene Chr3:94005165-94063256 (+)
WSB/EiJ MGP_WSBEiJ_G0026840
protein coding gene Chr3:96098364-96155122 (+)



Homology
more
  • Human Ortholog
    OTUD7B, OTU deubiquitinase 7B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    OTUD7B, OTU deubiquitinase 7B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CEZANNE, ZA20D1
  • Links
    NCBI Gene ID: 56957
    neXtProt AC: NX_Q6GQQ9
    UniProt: Q6GQQ9

  • Chr Location
    1q21.2; chr1:149940330-150010766 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10624
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: OTUD7B
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 4 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    1
  • Gene trapped
    17
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Otud7b
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele exhibit decreased body weight, tertiary lymphoid hyperplasia, increased stimulated B cell proliferation and survival and decreased susceptibility to C. rodentium infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038495 Ensembl Gene Model | MGI Sequence Detail 56603 C57BL/6J ±  kb
transcript ENSMUST00000090785 Ensembl | MGI Sequence Detail 8101 Not Applicable  
polypeptide ENSMUSP00000088291 Ensembl | MGI Sequence Detail 840 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1920219, MGI:1922172, MGI:2139730
References
more
  • Summaries
    All 52
    Diseases 1
    Gene Ontology 9
    Phenotypes 20
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:261316 Perez-Garcia V, et al., Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018 Mar 22;555(7697):463-468

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory