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Otud7b
Gene Detail
Symbol

Name
ID
Otud7b
OTU domain containing 7B
MGI:2654703
Synonyms
2900060B22Rik, 4930463P07Rik, Za20d1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
41.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:96104527-96161129 bp, + strand
From VEGA annotation of GRCm38

  56603 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10624  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Otud7b

Human
homologs
Human Homolog OTUD7B, OTU deubiquitinase 7B
NCBI Gene ID 56957
neXtProt AC  NX_Q6GQQ9
Human Synonyms  CEZANNE, ZA20D1
Human Chr (Location)  1q21.2; chr1:149940330-150067706 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(17) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit decreased body weight, tertiary lymphoid hyperplasia, increased stimulated B cell proliferation and survival and decreased susceptibility to C. rodentium infection.
 
Interactions
Otud7b interacts with 447 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process immune system process, mucosal immune response, ...
Component cytoplasm, nucleus
Function cysteine-type peptidase activity, DNA binding, ...
External Resources: FuncBase
Expression
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000021893 (Evidence)
Ensembl Gene ModelENSMUSG00000038495 (Evidence)
Entrez Gene229603 (Evidence)
DFCITC1678865, TC1641350, TC1633039, TC1617003, TC1631966
NIA Mouse Gene IndexU003587
EC3.4.19.12
Consensus CDS ProjectCCDS17629.1
International Mouse Knockout Project StatusOtud7b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021893 VEGA Gene Model | MGI Sequence Detail 56603 C57BL/6J ±  kb
transcript OTTMUST00000051991 VEGA | MGI Sequence Detail 8101 Not Applicable 
polypeptide OTTMUSP00000024551 VEGA | MGI Sequence Detail 840 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(24) UniProt(5)
Polymorphisms
SNPs within 2kb(248 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003323 Ovarian tumour, otubain
InterPro IPR009060 UBA-like
InterPro IPR002653 Zinc finger, A20-type
Protein Ontology PR:000012084 OTU domain-containing protein 7B
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209709 Luong le A, et al., Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination. Circ Res. 2013 Jun 7;112(12):1583-91
All references(43)
Other
accession IDs
MGI:1920219, MGI:1922172, MGI:2139730

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory