About   Help   FAQ
Cybrd1 Gene Detail
Summary
  • Symbol
    Cybrd1
  • Name
    cytochrome b reductase 1
  • Synonyms
    2210407P13Rik, Dcytb
  • Feature Type
    protein coding gene
  • IDs
    MGI:2654575
    NCBI Gene: 73649
Location & Maps
more
  • Sequence Map
    Chr2:71117923-71142926 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25004 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 42.38 cM, cytoband C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CYBRD1, cytochrome b reductase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CYBRD1, cytochrome b reductase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CYB561A2, DCYTB, FRRS3
  • Links
    NCBI Gene ID: 79901
    neXtProt AC: NX_Q53TN4

  • Chr Location
    2q31.1; chr2:171522247-171558133 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Cybrd1
  • Incidental Mutations
Mice homozygous for a knock-out allele show alterations in liver weight and liver iron content when fed an iron-deficient diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013155 VEGA Gene Model | MGI Sequence Detail 25004 C57BL/6J ±  kb
transcript OTTMUST00000031773 VEGA | MGI Sequence Detail 5339 Not Applicable  
polypeptide OTTMUSP00000014157 VEGA | MGI Sequence Detail 290 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    311 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006088 cytochrome b reductase 1
  • EC
  • InterPro Domains
    IPR006593 Cytochrome b561/ferric reductase transmembrane
    IPR028838 Cytochrome b reductase 1
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 4
Other
Accession IDs
less
MGI:1920899
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:210055 Luo X, et al., Modulation of Dcytb (Cybrd 1) expression and function by iron, dehydroascorbate and Hif-2alpha in cultured cells. Biochim Biophys Acta. 2014 Jan;1840(1):106-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory