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Cybrd1 Gene Detail
Summary
  • Symbol
    Cybrd1
  • Name
    cytochrome b reductase 1
  • Synonyms
    2210407P13Rik, Dcytb
  • Feature Type
    protein coding gene
  • IDs
    MGI:2654575
    NCBI Gene: 73649
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:71118054-71142926 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 42.38 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    311 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2654575
protein coding gene Chr2:71117923-71142926 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025819
protein coding gene Chr2:71194830-71223671 (+)
A/J MGP_AJ_G0025796
protein coding gene Chr2:68422919-68448984 (+)
AKR/J MGP_AKRJ_G0025765
protein coding gene Chr2:70290556-70315784 (+)
BALB/cJ MGP_BALBcJ_G0025791
protein coding gene Chr2:68612241-68637805 (+)
C3H/HeJ MGP_C3HHeJ_G0025551
protein coding gene Chr2:70505564-70533178 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026238
protein coding gene Chr2:73339666-73370146 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023641
protein coding gene Chr2:65648830-65676415 (+)
CAST/EiJ MGP_CASTEiJ_G0025015
protein coding gene Chr2:70680122-70708506 (+)
CBA/J MGP_CBAJ_G0025531
protein coding gene Chr2:76046664-76084226 (+)
DBA/2J MGP_DBA2J_G0025662
protein coding gene Chr2:68059384-68085459 (+)
FVB/NJ MGP_FVBNJ_G0025625
protein coding gene Chr2:67440669-67466161 (+)
LP/J MGP_LPJ_G0025751
protein coding gene Chr2:71056967-71085366 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025654
protein coding gene Chr2:78041877-78069537 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026295
protein coding gene Chr2:70383939-70410038 (+)
PWK/PhJ MGP_PWKPhJ_G0024756
protein coding gene Chr2:67918944-67945025 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024563
protein coding gene Chr2:70582321-70608543 (+)
WSB/EiJ MGP_WSBEiJ_G0025083
protein coding gene Chr2:70818667-70847469 (+)



Homology
more
  • Human Ortholog
    CYBRD1, cytochrome b reductase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CYBRD1, cytochrome b reductase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CYB561A2, DCYTB, FRRS3
  • Links
    NCBI Gene ID: 79901
    neXtProt AC: NX_Q53TN4
    UniProt: Q53TN4

  • Chr Location
    2q31.1; chr2:171522247-171558133 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show alterations in liver weight and liver iron content when fed an iron-deficient diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 73649 NCBI Gene Model | MGI Sequence Detail 24873 C57BL/6J ±  kb
    transcript NM_028593 RefSeq | MGI Sequence Detail 5208 C57BL/6  
    polypeptide Q925G2 UniProt | EBI | MGI Sequence Detail 290 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1920899
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    11/26/2019
    MGI 6.14
    The Jackson Laboratory