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Lrrc8a
Gene Detail
Symbol

Name
ID
Lrrc8a
leucine rich repeat containing 8A
MGI:2652847
Synonyms
Lrrc8, mKIAA1437
Feature Type
protein coding gene
Genetic Map
Chromosome 2
21.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:30237715-30263790 bp, + strand
From VEGA annotation of GRCm38

  26076 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18617  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: LRRC8A
Gene Tree: Lrrc8a

Human
homologs
LRRC8A, leucine rich repeat containing 8 family, member A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 56262
neXtProt AC: NX_Q8IWT6

Human Synonyms: AGM5, LRRC8, SWELL1

Human Chr (Location): 9q34.11; chr9:128882112-128918042 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LRRC8A

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Lrrc8a interacts with 235 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process anion transmembrane transport, anion transport, ...
Component cell surface, ion channel complex, ...
Function anion channel activity
External Resources: FuncBase
Expression
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lrrc8a    NEW 
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000016752 (Evidence)
Ensembl Gene Model ENSMUSG00000007476 (Evidence)
Entrez Gene 241296 (Evidence)
DFCI TC1588433, TC1582940
Consensus CDS Project CCDS15875.1
International Mouse Phenotyping Consortium Status Lrrc8a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016752 VEGA Gene Model | MGI Sequence Detail 26076 C57BL/6J ±  kb
transcript OTTMUST00000040641 VEGA | MGI Sequence Detail 4301 Not Applicable 
polypeptide OTTMUSP00000018164 VEGA | MGI Sequence Detail 810 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2)
Polymorphisms
SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000030752 leucine-rich repeat-containing protein 8A
References
(Earliest) J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
(Latest) J:211308 Kumar L, et al., Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med. 2014 May 5;211(5):929-42
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory