Lrrc8a
Gene Detail

Symbol Name ID

Lrrc8a leucine rich repeat containing 8A MGI:2652847

Synonyms

Lrrc8, mKIAA1437

Feature Type

protein coding gene

Genetic Map

Chromosome 2

21.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:30237715-30282148 bp, + strand From VEGA annotation of GRCm38   44434 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:18617  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 2 zebrafish

Gene Tree: Lrrc8a

Human homologs

Human Homolog		LRRC8A, leucine rich repeat containing 8 family, member A
NCBI Gene ID		56262
neXtProt AC		NX_Q8IWT6
Human Synonyms		AGM5, LRRC8
Human Chr (Location)		9q34.11; chr9:131644391-131680318 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LRRC8A

Alleles and phenotypes

All alleles(21) : Targeted(5) Gene trapped(16)

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	cell differentiation, pre-B cell differentiation
Component	integral to membrane, membrane
Function	molecular_function

External Resources: FuncBase

Expression

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(4) cDNA(4)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000016752 (Evidence)
Ensembl Gene Model	ENSMUSG00000007476 (Evidence)
Entrez Gene	241296 (Evidence)
DFCI	TC1582940, TC1588433
Consensus CDS Project	CCDS15875.1
International Mouse Knockout Project Status	Lrrc8a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016752	VEGA Gene Model | MGI Sequence Detail	44434	C57BL/6J
transcript	OTTMUST00000040641	VEGA | MGI Sequence Detail	4301	Not Applicable
polypeptide	OTTMUSP00000018164	VEGA | MGI Sequence Detail	810	Not Applicable

All sequences(24) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(40 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR025875	Leucine rich repeat 4
InterPro	IPR021040	Leucine-rich repeat-containing protein 8, N-terminal
InterPro	IPR003591	Leucine-rich repeat, typical subtype
Protein Ontology	PR:000030752	leucine-rich repeat-containing protein 8A

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
All references(29)