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Lrrc8a
Gene Detail
Symbol

Name
ID
Lrrc8a
leucine rich repeat containing 8A
MGI:2652847
Synonyms
Lrrc8, mKIAA1437
Feature Type
protein coding gene
Genetic Map
Chromosome 2
21.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:30237715-30263790 bp, + strand
From VEGA annotation of GRCm38

  26076 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18617  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Lrrc8a

Human
homologs
Human Homolog LRRC8A, leucine rich repeat containing 8 family, member A
NCBI Gene ID 56262
neXtProt AC  NX_Q8IWT6
Human Synonyms  AGM5, LRRC8, SWELL1
Human Chr (Location)  9q34.11; chr9:128882112-128918039 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LRRC8A
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Lrrc8a interacts with 235 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process anion transport, cell volume homeostasis, ...
Component cell surface, ion channel complex, ...
Function anion channel activity
External Resources: FuncBase
Expression
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000016752 (Evidence)
Ensembl Gene ModelENSMUSG00000007476 (Evidence)
Entrez Gene241296 (Evidence)
DFCITC1588433, TC1582940
Consensus CDS ProjectCCDS15875.1
International Mouse Knockout Project StatusLrrc8a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016752 VEGA Gene Model | MGI Sequence Detail 26076 C57BL/6J ±  kb
transcript OTTMUST00000040642 VEGA | MGI Sequence Detail 4194 Not Applicable 
polypeptide OTTMUSP00000018165 VEGA | MGI Sequence Detail 810 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2)
Polymorphisms
SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000030752 leucine-rich repeat-containing protein 8A
References
(Earliest) J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
(Latest) J:211308 Kumar L, et al., Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med. 2014 May 5;211(5):929-42
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory