63 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lrrc8aem1Uia/Lrrc8aem1Uia Tg(Adipoq-cre)1Evdr/0 involves: 129 * C57BL/6 * FVB/NJ	abnormal fat cell morphology	J:246515
	normal adipose tissue phenotype	J:246515
	decreased epididymal fat pad weight	J:246515
	decreased inguinal fat pad weight	J:246515
	decreased total body fat amount	J:246515
	hyperactivity	J:246515
	impaired glucose tolerance	J:246515
	increased energy expenditure	J:246515
	increased susceptibility to diet-induced obesity	J:246515
	insulin resistance	J:246515
Lrrc8atm1.1(KOMP)Vlcg/Lrrc8a+ C57BL/6N-Lrrc8atm1.1(KOMP)Vlcg/Ucd	abnormal eye morphology	J:211773
	abnormal lung morphology	J:211773
	enlarged lung	J:211773
Lrrc8atm1.1(KOMP)Vlcg/Lrrc8atm1.1(KOMP)Vlcg C57BL/6N-Lrrc8atm1.1(KOMP)Vlcg/MbpMmucd	abnormal craniofacial morphology	J:211773
	abnormal embryo size	J:211773
	anophthalmia	J:211773
	edema	J:211773
Lrrc8atm1.1(KOMP)Vlcg/Lrrc8atm1.1(KOMP)Vlcg C57BL/6N-Lrrc8atm1.1(KOMP)Vlcg/Ucd	preweaning lethality, complete penetrance	J:211773
Lrrc8atm1.1Geha/Lrrc8atm1.1Geha B6.129S1(Cg)-Lrrc8atm1.1Geha	abnormal B cell differentiation	J:211308
	abnormal renal tubule morphology	J:211308
	abnormal skeletal muscle morphology	J:211308
	abnormal T cell differentiation	J:211308
	abnormal T cell physiology	J:211308
	abnormal T cell selection	J:211308
	abnormal thymus apoptosis	J:211308
	abnormal thymus medulla morphology	J:211308
	abnormal thymus morphology	J:211308
	abnormal thymus physiology	J:211308
	absent corpus luteum	J:211308
	absent thymus corticomedullary boundary	J:211308
	decreased B cell number	J:211308
	decreased body weight	J:211308
	decreased CD4-positive, alpha-beta T cell number	J:211308
	decreased CD8-positive, alpha-beta T cell number	J:211308
	decreased DN2 thymocyte number	J:211308
	decreased DN3 thymocyte number	J:211308
	decreased DN4 thymocyte number	J:211308
	decreased double-negative T cell number	J:211308
	decreased double-positive T cell number	J:211308
	decreased immature B cell number	J:211308
	decreased marginal zone B cell number	J:211308
	decreased pre-B cell number	J:211308
	decreased T cell number	J:211308
	decreased T cell proliferation	J:211308
	decreased thymocyte number	J:211308
	decreased transitional stage B cell number	J:211308
	normal homeostasis/metabolism phenotype	J:211308
	hydronephrosis	J:211308
	hyperkeratosis	J:211308
	increased IgG2a level	J:211308
	increased pro-B cell number	J:211308
	increased regulatory T cell number	J:211308
	increased thymocyte apoptosis	J:211308
	infertility	J:211308
	paraparesis	J:211308
	postnatal growth retardation	J:211308
	premature death	J:211308
	prenatal lethality, incomplete penetrance	J:211308
	small spleen	J:211308
	small thymus	J:211308
	small thymus cortex	J:211308
	thymus hypoplasia	J:211308
	waved hair	J:211308