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Tub Gene Detail
Summary
  • Symbol
    Tub
  • Name
    tubby bipartite transcription factor
  • Synonyms
    rd5, tub
  • Feature Type
    protein coding gene
  • IDs
    MGI:2651573
    NCBI Gene: 22141
  • Gene Overview
    MyGene.info: TUB
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:109010880-109034459 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.21 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    310 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2651573
protein coding gene Chr7:108950338-109034460 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032837
protein coding gene Chr7:112414726-112433661 (+)
A/J MGP_AJ_G0032821
protein coding gene Chr7:109650845-109669768 (+)
AKR/J MGP_AKRJ_G0032752
protein coding gene Chr7:112383356-112402344 (+)
BALB/cJ MGP_BALBcJ_G0032825
protein coding gene Chr7:109347176-109367412 (+)
C3H/HeJ MGP_C3HHeJ_G0032535
protein coding gene Chr7:112420773-112446265 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033331
protein coding gene Chr7:117113478-117132545 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030304
protein coding gene Chr7:111239826-111258481 (+)
CAST/EiJ MGP_CASTEiJ_G0031863
protein coding gene Chr7:103947823-103988293 (+)
CBA/J MGP_CBAJ_G0032508
protein coding gene Chr7:120934425-120953794 (+)
DBA/2J MGP_DBA2J_G0032660
protein coding gene Chr7:107758658-107778017 (+)
FVB/NJ MGP_FVBNJ_G0032613
protein coding gene Chr7:107605215-107624142 (+)
LP/J MGP_LPJ_G0032754
protein coding gene Chr7:113973362-113992313 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032645
protein coding gene Chr7:122607499-122626369 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033352
protein coding gene Chr7:111407248-111428484 (+)
PWK/PhJ MGP_PWKPhJ_G0031570
protein coding gene Chr7:100561978-100600974 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031418
protein coding gene Chr7:98031580-98130222 (+)
WSB/EiJ MGP_WSBEiJ_G0031976
protein coding gene Chr7:112241511-112261818 (+)



Homology
more
  • Human Ortholog
    TUB, tubby bipartite transcription factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TUB, tubby bipartite transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    rd5, RDOB
  • Links
    NCBI Gene ID: 7275
    neXtProt AC: NX_P50607
    UniProt: P50607

  • Chr Location
    11p15.4; chr11:8019180-8106107 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tub mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 3 alleles in 7 genetic backgrounds
    6 phenotypes from multigenic genotypes
    5 images
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit a late-developing obesity with hyperinsulinemia, retinal degeneration, and hearing loss associated with death of both outer and inner hair cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22141 NCBI Gene Model | MGI Sequence Detail 23580 C57BL/6J ±  kb
    transcript NM_021885 RefSeq | MGI Sequence Detail 5941 C57BL/6  
    polypeptide P50586 UniProt | EBI | MGI Sequence Detail 505 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 8
      cDNA 13
      Primer pair 2
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13815, MGD-MRK-15299, MGI:97886, MGI:98868
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 13
      Phenotypes 53
    • Earliest
      J:10872 Coleman DL, et al., Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse. J Hered. 1990 Nov-Dec;81(6):424-7
    • Latest
      J:230760 Cai X, et al., Correlation of ER stress and retinal degeneration in tubby mice. Exp Eye Res. 2015 Nov;140:130-8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory