Tub
Gene Detail

Symbol Name ID

Tub tubby candidate gene MGI:2651573

Synonyms

rd5, tub

Feature Type

protein coding gene

Genetic Map

Chromosome 7

57.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr7:109010825-109034460 bp, + strand From VEGA annotation of GRCm38   23636 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31147  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tubby protein
Gene Tree: Tub

Human homologs

Human Homolog		TUB, tubby homolog (mouse)
NCBI Gene ID		7275
neXtProt AC		NX_P50607
Human Synonyms		rd5
Human Chr (Location)		11p15.5; chr11:8060180-8127654 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Spontaneous(1)
 

Homozygous mutants exhibit a late-developing obesity with hyperinsulinemia, retinal degeneration, and hearing loss associated with death of both outer and inner hair cells.

 
Human Diseases Modeled Using Mouse Tub (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	detection of visible light, G-protein coupled receptor signaling pathway, ...
Component	cytoplasm, cytosol, ...
Function	G-protein coupled photoreceptor activity, protein binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (192)    Tissues (142)   
Theiler Stages: 10, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	144
Northern blot	48

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(8) cDNA(11) Primer pair(2) Other(4)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000030291 (Evidence)
Ensembl Gene Model	ENSMUSG00000031028 (Evidence)
Entrez Gene	22141 (Evidence)
PDB	1C8Z, 1I7E
Consensus CDS Project	CCDS21732.1
International Mouse Knockout Project Status	Tub

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030291	VEGA Gene Model | MGI Sequence Detail	23636	C57BL/6J
transcript	OTTMUST00000074987	VEGA | MGI Sequence Detail	5997	Not Applicable
polypeptide	OTTMUSP00000039234	VEGA | MGI Sequence Detail	505	Not Applicable

All sequences(31) RefSeq(2) UniProt(4)

Polymorphisms

PCR(1) : SNPs(142 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000007	Tubby, C-terminal
InterPro	IPR018066	Tubby, C-terminal, conserved site
InterPro	IPR025659	Tubby C-terminal-like domain
InterPro	IPR005398	Tubby, N-terminal
Protein Ontology	PR:000016806	tubby protein

References

(Earliest) J:13772 Coleman DL, et al., Tubby (tub). Mouse News Lett. 1978;59:25
(Latest) J:195052 Mukhopadhyay S, et al., Cilia, tubby mice, and obesity. Cilia. 2013 Jan 3;2(1):1
All references(77)

Other accession IDs

MGD-MRK-13815, MGD-MRK-15299, MGI:97886, MGI:98868