About   Help   FAQ
Tub
Gene Detail
 Symbol
Name
ID
Tub
tubby candidate gene
MGI:2651573
Synonyms rd5, tub
Feature Type protein coding gene
Genetic Map
Chromosome 7
57.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr7:109010825-109034460 bp, + strand
From VEGA annotation of GRCm38

  23636 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31147  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tubby protein
Gene Tree: Tub

Human
homologs
Human Homolog TUB, tubby bipartite transcription factor
NCBI Gene ID 7275
neXtProt AC  NX_P50607
Human Synonyms  rd5
Human Chr (Location)  11p15.5; chr11:8019195-8106107 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit a late-developing obesity with hyperinsulinemia, retinal degeneration, and hearing loss associated with death of both outer and inner hair cells.
 
Human Diseases Modeled Using Mouse Tub (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Interactions
Tub interacts with 401 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process detection of visible light, G-protein coupled receptor signaling pathway, ...
Component cytoplasm, cytosol, ...
Function G-protein coupled photoreceptor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (192)    Tissues (142)   
Theiler Stages: 10, 15, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 144
Northern blot 48
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(8) cDNA(11) Primer pair(2) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000030291 (Evidence)
Ensembl Gene ModelENSMUSG00000031028 (Evidence)
Entrez Gene22141 (Evidence)
PDB1C8Z, 1I7E
Consensus CDS ProjectCCDS21732.1
International Mouse Knockout Project StatusTub
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030291 VEGA Gene Model | MGI Sequence Detail 23636 C57BL/6J ±  kb
transcript OTTMUST00000074987 VEGA | MGI Sequence Detail 5997 Not Applicable 
polypeptide OTTMUSP00000039234 VEGA | MGI Sequence Detail 505 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(4)
Polymorphisms PCR(1) : SNPs within 2kb(311 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000007 Tubby, C-terminal
InterPro IPR018066 Tubby, C-terminal, conserved site
InterPro IPR025659 Tubby C-terminal-like domain
InterPro IPR005398 Tubby, N-terminal
Protein Ontology PR:000016806 tubby protein
References (Earliest) J:13772 Coleman DL, et al., Tubby (tub). Mouse News Lett. 1978;59:25
(Latest) J:204140 Loktev AV, et al., Neuropeptide Y Family Receptors Traffic via the Bardet-Biedl Syndrome Pathway to Signal in Neuronal Primary Cilia. Cell Rep. 2013 Dec 12;5(5):1316-29
All references(83)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-13815, MGD-MRK-15299, MGI:97886, MGI:98868

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory