About   Help   FAQ
Tub
Gene Detail
Symbol

Name
ID
Tub
tubby candidate gene
MGI:2651573
Synonyms
rd5, tub
Feature Type
protein coding gene
Genetic Map
Chromosome 7
57.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr7:109010825-109034460 bp, + strand
From VEGA annotation of GRCm38

  23636 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31147  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TUB
Protein SuperFamily: tubby protein
Gene Tree: Tub

Human
homologs
TUB, tubby bipartite transcription factor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7275
neXtProt AC: NX_P50607

Human Synonyms: rd5, RDOB

Human Chr (Location): 11p15.5; chr11:8019180-8106241 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TUB

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutants exhibit a late-developing obesity with hyperinsulinemia, retinal degeneration, and hearing loss associated with death of both outer and inner hair cells.
 
Human Diseases Modeled in Mice Using Tub (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(5)
Interactions
Tub interacts with 400 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process phagocytosis, phagocytosis, recognition, ...
Component cilium, cytoplasm, ...
Function phosphatidylinositol binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (192)    Tissues (142)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 144
Northern blot 48
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tub    NEW 
Molecular
reagents
All nucleic(25) Genomic(8) cDNA(11) Primer pair(2) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000030291 (Evidence)
Ensembl Gene Model ENSMUSG00000031028 (Evidence)
Entrez Gene 22141 (Evidence)
PDB 1I7E, 1C8Z
Consensus CDS Project CCDS21732.1
International Mouse Phenotyping Consortium Status Tub
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030291 VEGA Gene Model | MGI Sequence Detail 23636 C57BL/6J ±  kb
transcript OTTMUST00000074987 VEGA | MGI Sequence Detail 5997 Not Applicable 
polypeptide OTTMUSP00000039234 VEGA | MGI Sequence Detail 505 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(311 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000007 Tubby, C-terminal
InterPro IPR018066 Tubby, C-terminal, conserved site
InterPro IPR025659 Tubby C-terminal-like domain
InterPro IPR005398 Tubby, N-terminal
Protein Ontology PR:000016806 tubby protein
References
(Earliest) J:13772 Coleman DL, et al., Tubby (tub). Mouse News Lett. 1978;59:25
(Latest) J:208476 Prada PO, et al., Tub has a key role in insulin and leptin signaling and action in vivo in hypothalamic nuclei. Diabetes. 2013 Jan;62(1):137-48
All references(84)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-13815, MGD-MRK-15299, MGI:97886, MGI:98868

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory