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Tspoap1 Gene Detail
Summary
  • Symbol
    Tspoap1
  • Name
    TSPO associated protein 1
  • Synonyms
    Bzrap1, mKIAA0612, peripheral
  • Feature Type
    protein coding gene
  • IDs
    MGI:2450877
    NCBI Gene: 207777
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:87651367-87676754 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 52.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    217 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2450877
protein coding gene Chr11:87649022-87676754 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018911
protein coding gene Chr11:89392775-89418614 (+)
A/J MGP_AJ_G0018878
protein coding gene Chr11:85946243-85972146 (+)
AKR/J MGP_AKRJ_G0018848
protein coding gene Chr11:88515809-88546266 (+)
BALB/cJ MGP_BALBcJ_G0018851
protein coding gene Chr11:86347937-86373306 (+)
C3H/HeJ MGP_C3HHeJ_G0018665
protein coding gene Chr11:88560572-88586772 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019303
protein coding gene Chr11:92108335-92135197 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016936
protein coding gene Chr11:82974008-82999710 (+)
CAST/EiJ MGP_CASTEiJ_G0018220
protein coding gene Chr11:89252494-89279605 (+)
CBA/J MGP_CBAJ_G0018636
protein coding gene Chr11:95977947-96003481 (+)
DBA/2J MGP_DBA2J_G0018744
protein coding gene Chr11:85500419-85526049 (+)
FVB/NJ MGP_FVBNJ_G0018733
protein coding gene Chr11:85006528-85031885 (+)
LP/J MGP_LPJ_G0018814
protein coding gene Chr11:89884332-89910937 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018760
protein coding gene Chr11:96017638-96042991 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019343
protein coding gene Chr11:88758439-88783785 (+)
PWK/PhJ MGP_PWKPhJ_G0017990
protein coding gene Chr11:86349703-86375156 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017783
protein coding gene Chr11:88317535-88342841 (+)
WSB/EiJ MGP_WSBEiJ_G0018271
protein coding gene Chr11:88649491-88676505 (+)



Homology
more
  • Human Ortholog
    TSPOAP1, TSPO associated protein 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSPOAP1, TSPO associated protein 1
  • Synonyms
    BZRAP1, DYT22, PBR-IP, PRAX1, PRAX-1, RIMBP1, RIM-BP1
  • Links
    NCBI Gene ID: 9256
    neXtProt AC: NX_O95153
    UniProt: O95153

  • Chr Location
    17q22; chr17:58301228-58328795 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human TSPOAP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous double-KO with Rimbp2tm1.2Geno does not exacerbate the phenotype of the latter single KO.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034156 Ensembl Gene Model | MGI Sequence Detail 25388 C57BL/6J ±  kb
    transcript ENSMUST00000039627 Ensembl | MGI Sequence Detail 7616 Not Applicable  
    polypeptide ENSMUSP00000048063 Ensembl | MGI Sequence Detail 1846 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 56
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 21
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:324135 Banerjee A, et al., Molecular and functional architecture of striatal dopamine release sites. Neuron. 2022 Jan 19;110(2):248-265.e9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory