Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rimbp2tm1.2Geno
Name:	RIMS binding protein 2; targeted mutation 1.2, Genoway
MGI ID:	MGI:6116836
Gene:	Rimbp2  Location: Chr5:128834855-129030550 bp, - strand  Genetic Position: Chr5, 67.91 cM
Alliance:	Rimbp2tm1.2Geno page

Germline Transmission:	Earliest citation of germline transmission: J:238503
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A LoxP site was inserted into intron 16 and an FRT-flanked neomycin resistance cassette and a second loxP site into intron 17. The neo cassette was removed through flp-mediated recombination and exon 17 was deleted through cre-mediated recombination. Immunoblot analysis and immunostaining of hippocampal cryosections confirmed absence of protein expression from this allele. (J:238503)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rimbp2 Mutation:	49 strains or lines available

Original:	J:238503 Grauel MK, et al., RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11615-11620
All:	3 reference(s)