All Phenotypes Rimbp2<tm1.2Geno> MGI Mouse

N

• ultra-structure of presynaptic active zone (AZ)

• readily releasable pool (RRP) size in synapses of cultured autaptic hippocampal glutamatergic neurons

• spontaneous miniature release in cultured autaptic hippocampal glutamatergic neurons and in CA1 pyramidal neurons in acute hippocampal slices

• excitatory postsynaptic potential at different volley amplitudes in acute hippocampal slices

abnormal synaptic plasticity ( J:238503 )

abnormal CNS synaptic transmission ( J:238503 )

• 10% reduction in vesicular release probability (ratio of excitatory postsynaptic current [EPSC] and readily releasable pool [RRP] charge) in cultured autaptic hippocampal glutamatergic neurons

• 21% reduction in vesicular release probability (ratio of excitatory postsynaptic current [EPSC] and readily releasable pool [RRP] charge) at low external Ca2+ concentrations in cultured autaptic hippocampal glutamatergic neurons

• vesicular release probability (ratio of excitatory postsynaptic current [EPSC] and readily releasable pool [RRP] charge) at high external Ca2+ concentrations in cultured autaptic hippocampal glutamatergic neurons

abnormal excitatory postsynaptic currents ( J:238503 )

• increased coefficient of variation in cultured autaptic hippocampal glutamatergic neurons

• 18% reduction in progressive block of the NMDA receptor-mediated component of EPSC by noncompetitive NMDA receptor blocker MK-801 in cultured autaptic hippocampal glutamatergic neurons

• increased coefficient of variation in cultured autaptic hippocampal glutamatergic neurons at low external Ca2+ concentrations

• 18% reduction in progressive block of the NMDA receptor-mediated component of EPSC by noncompetitive NMDA receptor blocker MK-801 at low external Ca2+ concentrations in cultured autaptic hippocampal glutamatergic neurons

• coefficient of variation in cultured autaptic hippocampal glutamatergic neurons at high external Ca2+ concentrations

• progressive block of the NMDA receptor-mediated component of EPSC by noncompetitive NMDA receptor blocker MK-801 at high external Ca2+ concentrations in cultured autaptic hippocampal glutamatergic neurons

decreased excitatory postsynaptic current amplitude ( J:238503 )

• decreased by 20% in cultured autaptic hippocampal glutamatergic neurons

enhanced paired-pulse facilitation ( J:238503 )

• increased after train stimulations with 25 pulses at 14 Hz in acute hippocampal slices

abnormal paired-pulse inhibition ( J:238503 )

• reduced after short bursts of five action potentials at 50 Hz and during 10-Hz action potential trains in cultured autaptic hippocampal glutamatergic neurons

• reduced after train stimulations with 25 pulses at 14 Hz in acute hippocampal slices

increased paired-pulse ratio ( J:238503 )

• increased paired-pulse ratio for all inter-stimulus intervals tested in acute hippocampal slices

• increased paired-pulse ratio at low external Ca2+ concentrations, with almost all inter-stimulus intervals tested, in cultured autaptic hippocampal glutamatergic neurons

• paired-pulse ratio at high external Ca2+ concentrations, with almost all inter-stimulus intervals tested, in cultured autaptic hippocampal glutamatergic neurons

reproductive system phenotype ( J:238503 )

N	• mice born at normal Mendelian ratios

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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