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Ifnl3 Gene Detail
Summary
  • Symbol
    Ifnl3
  • Name
    interferon lambda 3
  • Synonyms
    IFL-1, Il28, Il28b, INF-lambda
  • Feature Type
    protein coding gene
  • IDs
    MGI:2450574
    NCBI Gene: 338374
Location & Maps
more
  • Sequence Map
    Chr7:28522836-28524322 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1487 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 16.81 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    IFNL1, interferon lambda 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IFNL1, interferon lambda 1
    Orthology source: HGNC
  • Synonyms
    IL29, IL-29
  • Links
    NCBI Gene ID: 282618
    neXtProt AC: NX_Q8IU54

  • Chr Location
    19q13.13; chr19:39296325-39298672 (+)  GRCh38.p2

  • Human Ortholog
    IFNL2, interferon lambda 2
    Orthology source: HGNC
  • Synonyms
    IL28A, IL-28A
  • Links
    NCBI Gene ID: 282616
    neXtProt AC: NX_Q8IZJ0

  • Chr Location
    19q13.13; chr19:39265883-39270092 (+)  GRCh38.p2

  • Human Ortholog
    IFNL3, interferon lambda 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IL28B, IL-28B, IL28C
  • Links
    NCBI Gene ID: 282617
    neXtProt AC: NX_Q8IZI9

  • Chr Location
    19q13.13; chr19:39243606-39247034 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IFNL3 associations

Human Disease Mouse Models
       Hepatitis C Virus, Susceptibility to   OMIM: 609532
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
  • All Mutations and Alleles
    2
  • Targeted
    2
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059060 VEGA Gene Model | MGI Sequence Detail 1487 C57BL/6J ±  kb
transcript OTTMUST00000144890 VEGA | MGI Sequence Detail 582 Not Applicable  
polypeptide OTTMUSP00000075488 VEGA | MGI Sequence Detail 193 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    13 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR029177 Interferon lambda
Molecular
Reagents
less
  • All nucleic 2
    Other 2

    Microarray probesets 1
References
more
  • Summaries
    All 19
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:81434 Kotenko SV, et al., IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol. 2003 Jan;4(1):69-77
  • Latest
    J:189565 Sinha S, et al., IFN type I and type II independent enhancement of B cell TLR7 expression by natural killer cells. J Leukoc Biol. 2012 Oct;92(4):713-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory