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Ifnl3 Gene Detail
Summary
  • Symbol
    Ifnl3
  • Name
    interferon lambda 3
  • Synonyms
    IFL-1, Il28, Il28b, INF-lambda
  • Feature Type
    protein coding gene
  • IDs
    MGI:2450574
    NCBI Gene: 338374
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr7:28522836-28524322 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 16.81 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    13 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2450574
protein coding gene Chr7:28522833-28524401 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031949
protein coding gene Chr7:27304997-27306361 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0031858
protein coding gene Chr7:27319225-27321024 (-)
BALB/cJ MGP_BALBcJ_G0031933
protein coding gene Chr7:26794364-26796083 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0032399
protein coding gene Chr7:28178914-28185134 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029451
protein coding gene Chr7:27674745-27708581 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0031618
protein coding gene Chr7:29450644-29452145 (-)
DBA/2J MGP_DBA2J_G0031771
protein coding gene Chr7:26398003-26399802 (-)
FVB/NJ MGP_FVBNJ_G0031728
protein coding gene Chr7:26470485-26472260 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0031763
protein coding gene Chr7:28947835-28949604 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032428
protein coding gene Chr7:26771855-26809473 (-)
PWK/PhJ MGP_PWKPhJ_G0030713
protein coding gene Chr7:21371137-21405538 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0031097
protein coding gene Chr7:27116246-27155729 (-)



Homology
more
  • Human Ortholog
    IFNL1, interferon lambda 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IFNL1, interferon lambda 1
    Orthology source: HGNC
  • Synonyms
    IL29, IL-29
  • Links
    NCBI Gene ID: 282618
    neXtProt AC: NX_Q8IU54
    UniProt: Q8IU54

  • Chr Location
    19q13.2; chr19:39296325-39298672 (+)  GRCh38.p7

  • Human Ortholog
    IFNL2, interferon lambda 2
    Orthology source: HGNC
  • Synonyms
    IL28A, IL-28A
  • Links
    NCBI Gene ID: 282616
    neXtProt AC: NX_Q8IZJ0
    UniProt: Q8IZJ0

  • Chr Location
    19q13.2; chr19:39268517-39270092 (+)  GRCh38.p7

  • Human Ortholog
    IFNL3, interferon lambda 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IFN-lambda-3, IFN-lambda-4, IL28B, IL-28B, IL28C, IL-28C
  • Links
    NCBI Gene ID: 282617
    neXtProt AC: NX_Q8IZI9
    UniProt: Q8IZI9

  • Chr Location
    19q13.2; chr19:39243536-39245481 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000060747 Ensembl Gene Model | MGI Sequence Detail 1487 C57BL/6J ±  kb
transcript ENSMUST00000078364 Ensembl | MGI Sequence Detail 582 Not Applicable  
polypeptide ENSMUSP00000077473 Ensembl | MGI Sequence Detail 193 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR029177 Interferon lambda
    IPR038326 Interferon lambda superfamily
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 26
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:81434 Kotenko SV, et al., IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol. 2003 Jan;4(1):69-77
  • Latest
    J:250826 Wang Y, et al., Involvement of NK Cells in IL-28B-Mediated Immunity against Influenza Virus Infection. J Immunol. 2017 Aug 1;199(3):1012-1020

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory