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Ifnl3
Gene Detail
Symbol

Name
ID
Ifnl3
interferon lambda 3
MGI:2450574
Synonyms
IFL-1, Il28, Il28b, INF-lambda
Feature Type
protein coding gene
Genetic Map
Chromosome 7
16.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:28522836-28524322 bp, + strand
From NCBI annotation of GRCm38

  1487 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:77540  Vertebrate Homology Class
1 human; 2 mouse; 2 rat; 1 chimpanzee; 1 cattle; 1 dog; 2 chicken

Protein SuperFamily: interferon lambda
Gene Tree: Ifnl3

Human
homologs
Human Homolog IFNL3, interferon, lambda 3
NCBI Gene ID 282617
neXtProt AC  NX_Q8IZI9
Human Synonyms  IL28B, IL-28B, IL28C
Human Chr (Location)  19q13.13; chr19:39243632-39245077 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human IFNL3
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process defense response to virus, innate immune response, ...
Component extracellular region, extracellular space
Function cytokine activity, receptor binding
External Resources: FuncBase
Expression
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(2) Other(2)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000060747 (Evidence)
Entrez Gene338374 (Evidence)
UniGene246799
DoTSDT.101342922
Consensus CDS ProjectCCDS21047.1
International Mouse Knockout Project StatusIfnl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 338374 NCBI Gene Model | MGI Sequence Detail 1487 C57BL/6J ±  kb
transcript NM_177396 RefSeq | MGI Sequence Detail 582 C57BL/6 
polypeptide Q8CGK6 UniProt | EBI | MGI Sequence Detail 193 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(17 from dbSNP Build 137)    SNPs within 2kb including multiple locations(39)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000001470 interleukin-28B
Graphical View of Protein Domain Structure
References
(Earliest) J:81434 Kotenko SV, et al., IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol. 2003 Jan;4(1):69-77
(Latest) J:189565 Sinha S, et al., IFN type I and type II independent enhancement of B cell TLR7 expression by natural killer cells. J Leukoc Biol. 2012 Oct;92(4):713-22
All references(20)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory