Ifnl3
Gene Detail

Symbol Name ID

Ifnl3 interferon lambda 3 MGI:2450574

Synonyms

IFL-1, Il28, Il28b, INF-lambda

Feature Type

protein coding gene

Genetic Map

Chromosome 7

16.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:28522836-28524322 bp, + strand From NCBI annotation of GRCm38   1487 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:77540  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: interferon lambda
Gene Tree: Ifnl3

Human homologs

Human Homolog		IFNL3, interferon, lambda 3
NCBI Gene ID		282617
neXtProt AC		NX_Q8IZI9
Human Synonyms		IL28B, IL-28B, IL28C
Human Chr (Location)		19q13.13; chr19:39734272-39735611 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human IFNL3

Alleles and phenotypes

All alleles(1) : Targeted(1)

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	defense response to virus, innate immune response
Component	extracellular region, extracellular space
Function	cytokine activity, receptor binding

External Resources: FuncBase

Expression

External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(2) Other(2)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000060747 (Evidence)
Entrez Gene	338374 (Evidence)
UniGene	246799
DoTS	DT.101342922
Consensus CDS Project	CCDS21047.1
International Mouse Knockout Project Status	Ifnl3

Sequences

Length	Strain/Species
genomic	338374	NCBI Gene Model | MGI Sequence Detail	1487	C57BL/6J
transcript	NM_177396	RefSeq | MGI Sequence Detail	582	C57BL/6
polypeptide	Q8CGK6	UniProt | EBI | MGI Sequence Detail	193	Not Applicable

All sequences(12) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(6 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000001470	interleukin-28B

Graphical View of Protein Domain Structure

References

(Earliest) J:81434 Kotenko SV, et al., IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol. 2003 Jan;4(1):69-77
(Latest) J:189565 Sinha S, et al., IFN type I and type II independent enhancement of B cell TLR7 expression by natural killer cells. J Leukoc Biol. 2012 Oct;92(4):713-22
All references(18)