About   Help   FAQ
Ifnl3
Gene Detail
Symbol

Name
ID
Ifnl3
interferon lambda 3
MGI:2450574
Synonyms
IFL-1, Il28, Il28b, INF-lambda
Feature Type
protein coding gene
Genetic Map
Chromosome 7
16.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:28522836-28524322 bp, + strand
From Ensembl annotation of GRCm38

  1487 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:77540  Vertebrate Homology Class
1 human; 2 mouse; 2 rat; 1 chimpanzee; 1 cattle; 1 dog; 2 chicken

HCOP human homology predictions: IFNL1, IFNL2, IFNL3
Protein SuperFamily: interferon lambda
Gene Tree: Ifnl3

Human
homologs
IFNL1, interferon, lambda 1
Orthology source: HGNC

IDs:
NCBI Gene ID: 282618
neXtProt AC: NX_Q8IU54

Human Synonyms: IL29, IL-29

Human Chr (Location): 19q13.13; chr19:39296325-39298672 (+)  GRCh38.p2

  2 More Homolog(s):
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process defense response to virus, innate immune response, ...
Component extracellular region, extracellular space
Function cytokine activity, receptor binding
External Resources: FuncBase
Expression
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(2) Other(2)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000060747 (Evidence)
Entrez Gene 338374 (Evidence)
UniGene 246799
DoTS DT.101342922
Consensus CDS Project CCDS21047.1
International Mouse Phenotyping Consortium Status Ifnl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000060747 Ensembl Gene Model | MGI Sequence Detail 1487 C57BL/6J ±  kb
transcript ENSMUST00000078364 Ensembl | MGI Sequence Detail 582 Not Applicable 
polypeptide ENSMUSP00000077473 Ensembl | MGI Sequence Detail 193 Not Applicable 

For the selected sequences
All sequences(14) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(17 from dbSNP Build 137)    SNPs within 2kb including multiple locations(39)
Protein-related
information
ResourceIDDescription
InterPro IPR029177 Interferon lambda
Protein Ontology PR:000001470 interleukin-28B
References
(Earliest) J:81434 Kotenko SV, et al., IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol. 2003 Jan;4(1):69-77
(Latest) J:189565 Sinha S, et al., IFN type I and type II independent enhancement of B cell TLR7 expression by natural killer cells. J Leukoc Biol. 2012 Oct;92(4):713-22
All references(20)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory