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Cyp3a44 Gene Detail
Summary
  • Symbol
    Cyp3a44
  • Name
    cytochrome P450, family 3, subfamily a, polypeptide 44
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449818
    NCBI Gene: 337924
  • Gene Overview
    MyGene.info: CYP3A5
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:145773983-145805874 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 85.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449818
protein coding gene Chr5:145773983-145805891 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030371
protein coding gene Chr5:151307743-151351557 (-)
A/J MGP_AJ_G0030337
protein coding gene Chr5:144397718-144789725 (-)
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0030801
protein coding gene Chr5:156908418-156935123 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0030037
protein coding gene Chr5:163233156-163317941 (-)
DBA/2J MGP_DBA2J_G0030187
protein coding gene Chr5:144442553-144489580 (-)
FVB/NJ MGP_FVBNJ_G0030140
protein coding gene Chr5:143352734-143643973 (-)
LP/J MGP_LPJ_G0030275
protein coding gene Chr5:151515799-151550177 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030172
protein coding gene Chr5:165161296-165239623 (-)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CYP3A5, cytochrome P450 family 3 subfamily A member 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CYP3A5, cytochrome P450 family 3 subfamily A member 5
    Orthology source: HomoloGene
  • Synonyms
    CP35, CYPIIIA5, P450PCN3, PCN3
  • Links
    NCBI Gene ID: 1577
    neXtProt AC: NX_P20815
    UniProt: P20815

  • Chr Location
    7q22.1; chr7:99648189-99680026 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CYP3A5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054417 Ensembl Gene Model | MGI Sequence Detail 31892 C57BL/6J ±  kb
transcript ENSMUST00000067479 Ensembl | MGI Sequence Detail 1962 Not Applicable  
polypeptide ENSMUSP00000069932 Ensembl | MGI Sequence Detail 504 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR001128 Cytochrome P450
    IPR017972 Cytochrome P450, conserved site
    IPR008072 Cytochrome P450, E-class, CYP3A
    IPR002402 Cytochrome P450, E-class, group II
    IPR036396 Cytochrome P450 superfamily
Molecular
Reagents
less
  • All nucleic 12
    Genomic 10
    cDNA 2

    Microarray probesets 2
References
more
  • Summaries
    All 26
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:81656 Sakuma T, et al., Regulation of the expression of two female-predominant CYP3A mRNAs (CYP3A41 and CYP3A44) in mouse liver by sex and growth hormones. Arch Biochem Biophys. 2002 Aug 15;404(2):234-42
  • Latest
    J:262676 Chang MM, et al., Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes. Sci Rep. 2018 May 3;8(1):6960

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory