About   Help   FAQ
Upf2 Gene Detail
Summary
  • Symbol
    Upf2
  • Name
    UPF2 regulator of nonsense transcripts homolog (yeast)
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449307
    NCBI Gene: 326622
  • Gene Overview
    MyGene.info: UPF2
Location & Maps
more
  • Sequence Map
    Chr2:5951469-6056703 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      105235 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 3.62 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    UPF2, UPF2 regulator of nonsense transcripts homolog (yeast)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UPF2, UPF2 regulator of nonsense transcripts homolog (yeast)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HUPF2, RENT2, smg-3
  • Links
    NCBI Gene ID: 26019
    neXtProt AC: NX_Q9HAU5

  • Chr Location
    10p14; chr10:11920022-12043172 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 6101
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: UPF2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    61
  • Gene trapped
    57
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit early embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011208 VEGA Gene Model | MGI Sequence Detail 105235 C57BL/6J ±  kb
transcript OTTMUST00000026301 VEGA | MGI Sequence Detail 5174 Not Applicable  
polypeptide OTTMUSP00000012028 VEGA | MGI Sequence Detail 1269 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    322 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 64
    cDNA 64

    Microarray probesets 4
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:232556 Bao J, et al., UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts. PLoS Genet. 2016 May;12(5):e1005863

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory