Upf2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Upf2
UPF2 regulator of nonsense transcripts homolog (yeast)
MGI:2449307

27 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tg(Lck-cre)548Jxm/? Upf2^tm1Btp/Upf2^tm1Btp involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal T cell receptor beta chain V(D)J recombination	J:134765
	decreased CD4-positive, alpha-beta T cell number	J:134765
	decreased CD8-positive, alpha-beta T cell number	J:134765
	decreased double-positive T cell number	J:134765
	thymus hypoplasia	J:134765
Upf2^tm1.1Btp/Upf2^tm1.1Btp involves: 129P2/OlaHsd	embryonic lethality, complete penetrance	J:134765
Upf2^tm1Btp/Upf2^tm1Btp En1^tm2(cre)Wrst/En1⁺ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	abnormal cerebellum external granule cell layer morphology	J:306384
	cerebellum hypoplasia	J:306384
	decreased inferior colliculus size	J:306384
	decreased superior colliculus size	J:306384
	increased neuron apoptosis	J:306384
	increased neuronal precursor proliferation	J:306384
	loss of GABAergic neurons	J:306384
Upf2^tm1Btp/Upf2^tm1Btp Lyz2^tm1(cre)Ifo/? involves: 129P2/OlaHsd * C57BL/6 * CBA	normal immune system phenotype	J:134765
Upf2^tm1Btp/Upf2^tm1Btp Tg(Atoh1-cre)1Bfri/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal cerebellum anterior lobe morphology	J:306384
	abnormal cerebellum external granule cell layer morphology	J:306384
	decreased cerebellar granule cell number	J:306384
	increased neuronal precursor proliferation	J:306384
Upf2^tm1Btp/Upf2^tm1Btp Tg(Mx1-cre)1Cgn/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal B cell number	J:134765
	abnormal bone marrow cell morphology/development	J:134765
	abnormal common lymphocyte progenitor cell morphology	J:134765
	anemia	J:134765
	decreased granulocyte number	J:134765
	decreased hematocrit	J:134765
	decreased hematopoietic stem cell number	J:134765
	decreased hemoglobin content	J:134765
	decreased T cell proliferation	J:134765
	low mean erythrocyte cell number	J:134765
	premature death	J:134765

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23