Gars
Gene Detail

Symbol Name ID

Gars glycyl-tRNA synthetase MGI:2449057

Synonyms

Sgrp23

Feature Type

protein coding gene

Genetic Map

Chromosome 6

27.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:55038001-55079504 bp, + strand From NCBI annotation of GRCm38   41504 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1547  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glycine-tRNA ligase
Gene Tree: Gars

Human homologs

Human Homolog		GARS, glycyl-tRNA synthetase
NCBI Gene ID		2617
neXtProt AC		NX_P41250
Human Synonyms		CMT2D, DSMAV, GlyRS, HMN5, SMAD1
Human Chr (Location)		7p15; chr7:30634181-30673649 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human GARS

Alleles and phenotypes

All alleles(18) : Targeted(2) Gene trapped(14) Spontaneous(1) Chemically induced(1)
 

A dominant mutation results in sensory and motor axon degeneration in affected mice, with defects in synaptic transmission, nerve conduction and premature death. A loss of function mutation results in embryonic lethality in homozygous mice, and no discernable phenotype in heterozygous mice.

 
Human Diseases Modeled Using Mouse Gars (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	diadenosine tetraphosphate biosynthetic process, glycyl-tRNA aminoacylation, ...
Component	cytoplasm, mitochondrion, ...
Function	aminoacyl-tRNA ligase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (112)    Tissues (103)    Images (18)
Theiler Stages: 1, 2, 3, 4, 5, 22

Assay Type	Results
RNA in situ	94
RT-PCR	18

cDNA source data(193)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(195) cDNA(193) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000029777 (Evidence)
Entrez Gene	353172 (Evidence)
UniGene	250004
NIA Mouse Gene Index	U006902
EC	6.1.1.14
Consensus CDS Project	CCDS39492.1
International Mouse Knockout Project Status	Gars

Sequences

Length	Strain/Species
genomic	353172	NCBI Gene Model | MGI Sequence Detail	41504	C57BL/6J
transcript	NM_180678	RefSeq | MGI Sequence Detail	2390	C57BL/6
polypeptide	Q9CZD3	UniProt | EBI | MGI Sequence Detail	729	Not Applicable

All sequences(46) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(328 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006195	Aminoacyl-tRNA synthetase, class II
InterPro	IPR002314	Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain
InterPro	IPR004154	Anticodon-binding
InterPro	IPR002315	Glycyl-tRNA synthetase, alpha2 dimer
InterPro	IPR009068	S15/NS1, RNA-binding
InterPro	IPR000738	WHEP-TRS
Protein Ontology	PR:000007846	glycyl-tRNA synthetase

Graphical View of Protein Domain Structure

References

(Earliest) J:36876 Lang IM, et al., Purification of storage granule protein-23. A novel protein identified by phage display technology and interaction with type I plasminogen activator inhibitor. J Biol Chem. 1996 Nov 22;271(47):30126-35
(Latest) J:179811 Motley WW, et al., Charcot-Marie-Tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels. PLoS Genet. 2011 Dec;7(12):e1002399
All references(39)

Other accession IDs

MGD-MRK-38321, MGI:109276, MGI:3513829