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Gars
Gene Detail
 Symbol
Name
ID
Gars
glycyl-tRNA synthetase
MGI:2449057
Synonyms Gena201, GENA202, Sgrp23
Feature Type protein coding gene
Genetic Map
Chromosome 6
27.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:55038001-55079504 bp, + strand
From NCBI annotation of GRCm38

  41504 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1547  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glycine-tRNA ligase
Gene Tree: Gars

Human
homologs
Human Homolog GARS, glycyl-tRNA synthetase
NCBI Gene ID 2617
neXtProt AC  NX_P41250
Human Synonyms  CMT2D, DSMAV, GlyRS, HMN5, SMAD1
Human Chr (Location)  7p15; chr7:30594565-30634033 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human GARS
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Chemically induced (ENU)(1) Gene trapped(14) Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
A dominant mutation results in sensory and motor axon degeneration in affected mice, with defects in synaptic transmission, nerve conduction and premature death. A loss of function mutation results in embryonic lethality in homozygous mice, and no discernable phenotype in heterozygous mice.
 
Human Diseases Modeled Using Mouse Gars (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Gars interacts with 66 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process diadenosine tetraphosphate biosynthetic process, glycyl-tRNA aminoacylation, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function aminoacyl-tRNA ligase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (104)    Tissues (99)    Images (18)
Theiler Stages: 1, 2, 3, 5, 22
Assay TypeResults
RNA in situ 94
RT-PCR 10
cDNA source data(194)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(196) cDNA(194) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000029777 (Evidence)
Entrez Gene353172 (Evidence)
UniGene250004
NIA Mouse Gene IndexU006902
EC6.1.1.14
Consensus CDS ProjectCCDS39492.1
International Mouse Knockout Project StatusGars
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 353172 NCBI Gene Model | MGI Sequence Detail 41504 C57BL/6J ±  kb
transcript NM_180678 RefSeq | MGI Sequence Detail 2390 C57BL/6 
polypeptide Q9CZD3 UniProt | EBI | MGI Sequence Detail 729 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(361 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006195 Aminoacyl-tRNA synthetase, class II
InterPro IPR002314 Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain
InterPro IPR004154 Anticodon-binding
InterPro IPR002315 Glycyl-tRNA synthetase, alpha2 dimer
InterPro IPR027031 Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2
InterPro IPR009068 S15/NS1, RNA-binding
InterPro IPR000738 WHEP-TRS
Protein Ontology PR:000007846 glycine--tRNA ligase
Graphical View of Protein Domain Structure
References (Earliest) J:36876 Lang IM, et al., Purification of storage granule protein-23. A novel protein identified by phage display technology and interaction with type I plasminogen activator inhibitor. J Biol Chem. 1996 Nov 22;271(47):30126-35
(Latest) J:209061 Sleigh JN, et al., Neuromuscular junction maturation defects precede impaired lower motor neuron connectivity in Charcot-Marie-Tooth type 2D mice. Hum Mol Genet. 2014 May 15;23(10):2639-50
All references(42)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-38321, MGI:109276, MGI:3513829, MGI:3686757

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/02/2014
MGI 5.19
The Jackson Laboratory