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Gars Gene Detail
Summary
  • Symbol
    Gars
  • Name
    glycyl-tRNA synthetase
  • Synonyms
    Gena201, GENA202, Sgrp23
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449057
    NCBI Gene: 353172
  • Gene Overview
    MyGene.info: GARS
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:55038007-55079500 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 27.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    359 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449057
protein coding gene Chr6:55038001-55079504 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030768
protein coding gene Chr6:54435280-54477383 (+)
A/J MGP_AJ_G0030737
protein coding gene Chr6:51901643-51942473 (+)
AKR/J MGP_AKRJ_G0030664
protein coding gene Chr6:53668319-53709282 (+)
BALB/cJ MGP_BALBcJ_G0030749
protein coding gene Chr6:52271888-52313228 (+)
C3H/HeJ MGP_C3HHeJ_G0030462
protein coding gene Chr6:53689499-53732479 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031204
protein coding gene Chr6:55645249-55691915 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028410
protein coding gene Chr6:49512442-49555157 (+)
CAST/EiJ MGP_CASTEiJ_G0029865
protein coding gene Chr6:53547150-53589628 (+)
CBA/J MGP_CBAJ_G0030436
protein coding gene Chr6:57948924-57995251 (+)
DBA/2J MGP_DBA2J_G0030586
protein coding gene Chr6:51803033-51844086 (+)
FVB/NJ MGP_FVBNJ_G0030538
protein coding gene Chr6:51395567-51437411 (+)
LP/J MGP_LPJ_G0030671
protein coding gene Chr6:54369892-54412396 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030572
protein coding gene Chr6:60451514-60497047 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031234
protein coding gene Chr6:53635087-53676177 (+)
PWK/PhJ MGP_PWKPhJ_G0029578
protein coding gene Chr6:51467009-51508368 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029412
protein coding gene Chr6:53007899-53048987 (+)
WSB/EiJ MGP_WSBEiJ_G0029942
protein coding gene Chr6:53659079-53702555 (+)



Homology
more
  • Human Ortholog
    GARS, glycyl-tRNA synthetase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GARS, glycyl-tRNA synthetase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMT2D, DSMAV, GlyRS, HMN5, SMAD1
  • Links
    NCBI Gene ID: 2617
    neXtProt AC: NX_P41250
    UniProt: P41250

  • Chr Location
    7p14.3; chr7:30594735-30634033 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Gars mouse models; 1 with human GARS associations

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 3 alleles in 8 genetic backgrounds
    14 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
A dominant mutation results in sensory and motor axon degeneration in affected mice, with defects in synaptic transmission, nerve conduction and premature death. A loss of function mutation results in embryonic lethality in homozygous mice, and no discernable phenotype in heterozygous mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029777 Ensembl Gene Model | MGI Sequence Detail 41494 C57BL/6J ±  kb
    transcript ENSMUST00000003572 Ensembl | MGI Sequence Detail 2380 Not Applicable  
    polypeptide ENSMUSP00000003572 Ensembl | MGI Sequence Detail 729 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 197
      cDNA 195
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38321, MGI:109276, MGI:3513829, MGI:3686757
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 3
      Diseases 3
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:36876 Lang IM, et al., Purification of storage granule protein-23. A novel protein identified by phage display technology and interaction with type I plasminogen activator inhibitor. J Biol Chem. 1996 Nov 22;271(47):30126-35
    • Latest
      J:259704 Mo Z, et al., Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy. Nat Commun. 2018 Mar 8;9(1):1007

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory