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Atcay Gene Detail
Summary
  • Symbol
    Atcay
  • Name
    ataxia, cerebellar, Cayman type
  • Synonyms
    3322401A10Rik, BNIP-H, ji
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448730
    NCBI Gene: 16467
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:81204513-81230779 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448730
protein coding gene Chr10:81204508-81230833 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017543
protein coding gene Chr10:81904350-81931973 (-)
A/J MGP_AJ_G0017521
protein coding gene Chr10:79004893-79033931 (-)
AKR/J MGP_AKRJ_G0017482
protein coding gene Chr10:81181004-81207566 (-)
BALB/cJ MGP_BALBcJ_G0017483
protein coding gene Chr10:79224196-79252428 (-)
C3H/HeJ MGP_C3HHeJ_G0017306
protein coding gene Chr10:81269549-81299930 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017937
protein coding gene Chr10:84719908-84749015 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015626
protein coding gene Chr10:75203564-75231167 (-)
CAST/EiJ MGP_CASTEiJ_G0016873
protein coding gene Chr10:81502339-81529761 (-)
CBA/J MGP_CBAJ_G0017278
protein coding gene Chr10:88016517-88054290 (-)
DBA/2J MGP_DBA2J_G0017384
protein coding gene Chr10:78212797-78239181 (-)
FVB/NJ MGP_FVBNJ_G0017378
protein coding gene Chr10:77453242-77483366 (-)
LP/J MGP_LPJ_G0017455
protein coding gene Chr10:82356567-82387111 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017404
protein coding gene Chr10:89880858-89910558 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017978
protein coding gene Chr10:81169435-81209777 (-)
PWK/PhJ MGP_PWKPhJ_G0016654
protein coding gene Chr10:78103661-78131093 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016444
protein coding gene Chr10:80126353-80157922 (-)
WSB/EiJ MGP_WSBEiJ_G0016933
protein coding gene Chr10:81209101-81239072 (-)



Homology
more
  • Human Ortholog
    ATCAY, ATCAY, caytaxin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ATCAY, ATCAY, caytaxin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BNIP-H, CLAC
  • Links
    NCBI Gene ID: 85300
    neXtProt AC: NX_Q86WG3
    UniProt: Q86WG3

  • Chr Location
    19p13.3; chr19:3880620-3928082 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Atcay mouse models; 1 with human ATCAY associations

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 5 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutants homozygous for a severe allele show progressive impaired coordination and seizures beginning by 10-16 days of age and die by 4 weeks of age. Homozygotes for milder alleles have abnormal gait, slightly diminished body size and reduced male fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16467 NCBI Gene Model | MGI Sequence Detail 26267 C57BL/6J ±  kb
    transcript NM_178662 RefSeq | MGI Sequence Detail 3693 C57BL/6  
    polypeptide Q8BHE3 UniProt | EBI | MGI Sequence Detail 372 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 50

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10693, MGD-MRK-11529, MGI:2143893, MGI:2442176, MGI:96640
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:300 Snell GD, Linkage of jittery and waltzing in the mouse. J Hered. 1945;36:279-80
    • Latest
      J:212116 Luna-Cancalon K, et al., Alterations in cerebellar physiology are associated with a stiff-legged gait in Atcay(ji-hes) mice. Neurobiol Dis. 2014 Jul;67:140-8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory