Atcay^ji-hes
Spontaneous Allele Detail

Summary

• Symbol: Atcay^ji-hes
• Name: ataxia, cerebellar, Cayman type; jittery hesitant
• MGI ID: MGI:1856898
• Synonyms: hes, ji^hes
• Gene: Atcay Location: Chr10:81040342-81066667 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Atcay^ji-hes page

Mutation origin

• Strain of Origin: C3H/HeJ-Tyr^c-a

Mutation description

Allele Type: Spontaneous Mutation: Transposon insertion Mutation details: The mutation in the hesitant mouse has been identified as an IAP insertion in intron 1 that results in large aberrant transcripts and small amounts of normal transcript. (J:85793) Inheritance: Recessive

Schematic of the location of the IAP insertion generating the Atcay^ji-hes allele

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atcay Mutation: 27 strains or lines available

Notes

Homozygotes can be recognized at 14 days of age by their slightly smaller size and hesitant walking motion. From 3 weeks of age on, mutants' hindlimbs hesitate after lifting and then are placed flat on the surface and stiffly extended causing the posterior to rise. No body tremors, spasticity, or muscle degeneration is observed. Homozygotes of both sexes are fertile, although fertility in males may be reduced(J:1771).

References

• Original: J:1771 Sweet HO, Hesitant (hes). Mouse Genome. 1991;89(4):844
• All: 6 reference(s)