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Nyx Gene Detail
Summary
  • Symbol
    Nyx
  • Name
    nyctalopin
  • Synonyms
    CLNP, CSNB1, CSNB4, MGC:38926, nob
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448607
    NCBI Gene: 236690
  • Gene Overview
    MyGene.info: NYX
Location & Maps
more
  • Sequence Map
    ChrX:13466110-13489313 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23204 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 8.37 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NYX, nyctalopin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NYX, nyctalopin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CLRP, CSNB1, CSNB1A, CSNB4, NBM1
  • Links
    NCBI Gene ID: 60506
    neXtProt AC: NX_Q9GZU5

  • Chr Location
    Xp11.4; chrX:41445637-41476421 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11210
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NYX
  • Gene Tree
    Nyx
Human Diseases
more
  • Diseases
    1 with Nyx mouse models; 1 with human NYX associations

Human Disease Mouse Models
       Night Blindness, Congenital Stationary, Type 1A; CSNB1A   OMIM: 310500 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    1
  • Spontaneous
    1
  • Incidental Mutations
Mice homozygous for a spontaneous mutation fail to display the dark-adapted electroretinographic b-wave, and exhibit abnormal rod and cone electrophysiology, and absent visual evoked potential.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016909 VEGA Gene Model | MGI Sequence Detail 23204 C57BL/6J ±  kb
transcript OTTMUST00000041035 VEGA | MGI Sequence Detail 5183 Not Applicable  
polypeptide OTTMUSP00000018381 VEGA | MGI Sequence Detail 476 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    57 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000011548 nyctalopin
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 3
Other
Accession IDs
less
MGI:1328327
References
more
  • Summaries
    All 40
    Diseases 1
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:50824 Pardue MT, et al., A naturally occurring mouse model of X-linked congenital stationary night blindness. Invest Ophthalmol Vis Sci. 1998 Nov;39(12):2443-9
  • Latest
    J:230179 Chakraborty R, et al., Refractive index measurement of the mouse crystalline lens using optical coherence tomography. Exp Eye Res. 2014 Aug;125:62-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory