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Nyx
Gene Detail
Symbol

Name
ID
Nyx
nyctalopin
MGI:2448607
Synonyms
CLNP, CSNB1, CSNB4, MGC:38926, nob
Feature Type
protein coding gene
Genetic Map
Chromosome X
8.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:13466110-13489313 bp, + strand
From VEGA annotation of GRCm38

  23204 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11210  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nyx

Human
homologs
Human Homolog NYX, nyctalopin
NCBI Gene ID 60506
neXtProt AC  NX_Q9GZU5
Human Synonyms  CLRP, CSNB1, CSNB1A, CSNB4, NBM1
Human Chr (Location)  Xp11.4; chrX:41447460-41475652 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human NYX
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Spontaneous(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous mutation fail to display the dark-adapted electroretinographic b-wave, and exhibit abnormal rod and cone electrophysiology, and absent visual evoked potential.
 
Human Diseases Modeled Using Mouse Nyx (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Nyx interacts with 195 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process response to stimulus, visual perception
Component extracellular region, intracellular, ...
External Resources: FuncBase
Expression
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016909 (Evidence)
Ensembl Gene ModelENSMUSG00000051228 (Evidence)
Entrez Gene236690 (Evidence)
UniGene90233
DFCITC1587949
DoTSDT.40162928, DT.94198888, DT.94255582
NIA Mouse Gene IndexU019725
Consensus CDS ProjectCCDS40877.1
International Mouse Knockout Project StatusNyx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016909 VEGA Gene Model | MGI Sequence Detail 23204 C57BL/6J ±  kb
transcript OTTMUST00000041035 VEGA | MGI Sequence Detail 5183 Not Applicable 
polypeptide OTTMUSP00000018381 VEGA | MGI Sequence Detail 476 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(12) UniProt(1)
Polymorphisms
SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000011548 nyctalopin
References
(Earliest) J:50824 Pardue MT, et al., A naturally occurring mouse model of X-linked congenital stationary night blindness. Invest Ophthalmol Vis Sci. 1998 Nov;39(12):2443-9
(Latest) J:211063 Ray TA, et al., GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells. J Neurosci. 2014 Apr 30;34(18):6334-43
All references(42)
Disease annotation references (1)
Other
accession IDs
MGI:1328327

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory