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Nyx Gene Detail
Summary
  • Symbol
    Nyx
  • Name
    nyctalopin
  • Synonyms
    CLNP, CSNB1, CSNB4, MGC:38926, nob
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448607
    NCBI Gene: 236690
  • Gene Overview
    MyGene.info: NYX
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:13466110-13489313 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 8.37 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448607
protein coding gene ChrX:13461095-13489321 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035572
protein coding gene ChrX:8329861-8354165 (+)
A/J MGP_AJ_G0035550
protein coding gene ChrX:8407858-8430998 (+)
AKR/J MGP_AKRJ_G0035482
protein coding gene ChrX:8692154-8716593 (+)
BALB/cJ MGP_BALBcJ_G0035543
protein coding gene ChrX:8265737-8290732 (+)
C3H/HeJ MGP_C3HHeJ_G0035259
protein coding gene ChrX:8433047-8456261 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036072
protein coding gene ChrX:8533949-8560306 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032942
protein coding gene ChrX:7304264-7326560 (+)
CAST/EiJ MGP_CASTEiJ_G0034551
protein coding gene ChrX:8163115-8185540 (+)
CBA/J MGP_CBAJ_G0035228
protein coding gene ChrX:8971650-8996742 (+)
DBA/2J MGP_DBA2J_G0035381
protein coding gene ChrX:8249461-8272587 (+)
FVB/NJ MGP_FVBNJ_G0035328
protein coding gene ChrX:8084864-8108323 (+)
LP/J MGP_LPJ_G0035463
protein coding gene ChrX:8502052-8525274 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035371
protein coding gene ChrX:8880318-8903463 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036084
protein coding gene ChrX:8243959-8268268 (+)
PWK/PhJ MGP_PWKPhJ_G0034252
protein coding gene ChrX:7729826-7758228 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034093
protein coding gene ChrX:8340027-8363526 (+)
WSB/EiJ MGP_WSBEiJ_G0034687
protein coding gene ChrX:8278551-8301728 (+)



Homology
more
  • Human Ortholog
    NYX, nyctalopin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NYX, nyctalopin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CLRP, CSNB1, CSNB1A, CSNB4, NBM1
  • Links
    NCBI Gene ID: 60506
    neXtProt AC: NX_Q9GZU5
    UniProt: Q9GZU5

  • Chr Location
    Xp11.4; chrX:41447460-41476414 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11210
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NYX
  • Gene Tree
    Nyx
Human Diseases
more
  • Diseases
    1 with Nyx mouse models; 1 with human NYX associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous mutation fail to display the dark-adapted electroretinographic b-wave, and exhibit abnormal rod and cone electrophysiology, and absent visual evoked potential.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051228 Ensembl Gene Model | MGI Sequence Detail 23204 C57BL/6J ±  kb
transcript ENSMUST00000050434 Ensembl | MGI Sequence Detail 5183 Not Applicable  
polypeptide ENSMUSP00000056313 Ensembl | MGI Sequence Detail 476 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 3
Other
Accession IDs
less
MGI:1328327
References
more
  • Summaries
    All 42
    Diseases 1
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:50824 Pardue MT, et al., A naturally occurring mouse model of X-linked congenital stationary night blindness. Invest Ophthalmol Vis Sci. 1998 Nov;39(12):2443-9
  • Latest
    J:257448 Tarchick MJ, et al., Early Functional and Morphologic Abnormalities in the Diabetic Nyxnob Mouse Retina. Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3496-508

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory