About   Help   FAQ
Nyx
Gene Detail
Symbol

Name
ID
Nyx
nyctalopin
MGI:2448607
Synonyms
CLNP, CSNB1, CSNB4, MGC:38926, nob
Feature Type
protein coding gene
Genetic Map
Chromosome X
8.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:13466110-13489313 bp, + strand
From VEGA annotation of GRCm38

  23204 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11210  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NYX
Gene Tree: Nyx

Human
homologs
NYX, nyctalopin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 60506
neXtProt AC: NX_Q9GZU5

Human Synonyms: CLRP, CSNB1, CSNB1A, CSNB4, NBM1

Human Chr (Location): Xp11.4; chrX:41445637-41476421 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NYX

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Spontaneous(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous mutation fail to display the dark-adapted electroretinographic b-wave, and exhibit abnormal rod and cone electrophysiology, and absent visual evoked potential.
 
Human Diseases Modeled in Mice Using Nyx (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Nyx interacts with 194 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process response to stimulus, visual perception
Component extracellular region, intracellular, ...
External Resources: FuncBase
Expression
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN nyx    NEW 
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016909 (Evidence)
Ensembl Gene Model ENSMUSG00000051228 (Evidence)
Entrez Gene 236690 (Evidence)
UniGene 90233
DFCI TC1587949
DoTS DT.40162928, DT.94255582, DT.94198888
NIA Mouse Gene Index U019725
Consensus CDS Project CCDS40877.1
International Mouse Phenotyping Consortium Status Nyx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016909 VEGA Gene Model | MGI Sequence Detail 23204 C57BL/6J ±  kb
transcript OTTMUST00000041035 VEGA | MGI Sequence Detail 5183 Not Applicable 
polypeptide OTTMUSP00000018381 VEGA | MGI Sequence Detail 476 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(12) UniProt(1)
Polymorphisms
SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000011548 nyctalopin
References
(Earliest) J:50824 Pardue MT, et al., A naturally occurring mouse model of X-linked congenital stationary night blindness. Invest Ophthalmol Vis Sci. 1998 Nov;39(12):2443-9
(Latest) J:211063 Ray TA, et al., GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells. J Neurosci. 2014 Apr 30;34(18):6334-43
All references(41)
Disease annotation references (1)
Other
accession IDs
MGI:1328327

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory