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Chd2 Gene Detail
Summary
  • Symbol
    Chd2
  • Name
    chromodomain helicase DNA binding protein 2
  • Synonyms
    2810013C04Rik, 2810040A01Rik, 5630401D06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448567
    NCBI Gene: 244059
  • Gene Overview
    MyGene.info: CHD2
Location & Maps
more
  • Sequence Map
    Chr7:73426638-73541830 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      115193 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CHD2, chromodomain helicase DNA binding protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CHD2, chromodomain helicase DNA binding protein 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EEOC
  • Links
    NCBI Gene ID: 1106
    neXtProt AC: NX_O14647

  • Chr Location
    15q26; chr15:92900321-93028007 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 37462
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CHD2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Chd2 mouse models; 1 with human CHD2 associations

Human Disease Mouse Models
       CHARGE Syndrome   OMIM: 214800 View 1 model
       Epileptic Encephalopathy, Childhood-Onset; EEOC   OMIM: 615369
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    82 phenotypes from 2 alleles in 3 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    199
  • Chemically induced (other)
    1
  • Gene trapped
    192
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    3 involving Chd2
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit early postnatal lethality associated with fetal growth retardation. Mice heterozygous for a gene trap allele exhibit postnatal lethality and premature death after weaning associated with growth retardation and multi-organ defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036993 VEGA Gene Model | MGI Sequence Detail 115193 C57BL/6J ±  kb
transcript OTTMUST00000095121 VEGA | MGI Sequence Detail 9085 Not Applicable  
polypeptide OTTMUSP00000053039 VEGA | MGI Sequence Detail 1827 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    466 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 6
Other
Accession IDs
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MGI:1917209, MGI:1918687, MGI:1924276, MGI:2142057
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 5
    Phenotypes 25
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:204624 Harada A, et al., Chd2 interacts with H3.3 to determine myogenic cell fate. EMBO J. 2012 Jun 29;31(13):2994-3007

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory