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Pi4ka Gene Detail
Summary
  • Symbol
    Pi4ka
  • Name
    phosphatidylinositol 4-kinase alpha
  • Synonyms
    Pik4ca
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448506
    NCBI Gene: 224020
  • Gene Overview
    MyGene.info: PI4KA
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17280351-17406314 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 10.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    542 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448506
protein coding gene Chr16:17280351-17406314 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022577
protein coding gene Chr16:14419058-14556626 (-)
A/J MGP_AJ_G0022538
protein coding gene Chr16:13703068-13832422 (-)
AKR/J MGP_AKRJ_G0022515
protein coding gene Chr16:14249197-14375294 (-)
BALB/cJ MGP_BALBcJ_G0022541
protein coding gene Chr16:13848167-13976962 (-)
C3H/HeJ MGP_C3HHeJ_G0022308
protein coding gene Chr16:14385521-14520636 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022992
protein coding gene Chr16:14650154-14787610 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020512
protein coding gene Chr16:13778675-13905572 (-)
CAST/EiJ MGP_CASTEiJ_G0021836
protein coding gene Chr16:14294035-14424581 (-)
CBA/J MGP_CBAJ_G0022279
protein coding gene Chr16:15325922-15453817 (-)
DBA/2J MGP_DBA2J_G0022409
protein coding gene Chr16:13628309-13755192 (-)
FVB/NJ MGP_FVBNJ_G0022385
protein coding gene Chr16:13670420-13796210 (-)
LP/J MGP_LPJ_G0022476
protein coding gene Chr16:14180534-14317875 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022406
protein coding gene Chr16:15005217-15153598 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023003
protein coding gene Chr16:14182575-14314992 (-)
PWK/PhJ MGP_PWKPhJ_G0021579
protein coding gene Chr16:13873194-14003951 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021407
protein coding gene Chr16:14169015-14296777 (-)
WSB/EiJ MGP_WSBEiJ_G0021883
protein coding gene Chr16:14187051-14315554 (-)



Homology
more
  • Human Ortholog
    PI4KA, phosphatidylinositol 4-kinase alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PI4KA, phosphatidylinositol 4-kinase alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    pi4K230, PI4K-ALPHA, PIK4CA, PMGYCHA
  • Links
    NCBI Gene ID: 5297
    neXtProt AC: NX_P42356
    UniProt: P42356

  • Chr Location
    22q11.21; chr22:20707691-20858812 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11171
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PI4KA
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 5 alleles in 6 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted knock-out or knock-in conditionally activated exhibit premature death associated with degeneration of mucosal cells in the stomach and intestines. Mice homozygous for a knock-out allele exhibit early embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224020 NCBI Gene Model | MGI Sequence Detail 125964 C57BL/6J ±  kb
    transcript NM_001001983 RefSeq | MGI Sequence Detail 6449 C57BL/6  
    polypeptide E9Q3L2 UniProt | EBI | MGI Sequence Detail 2105 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • EC
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
      IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
      IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
      IPR015433 Phosphatidylinositol kinase
      IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
      IPR011009 Protein kinase-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 158
      cDNA 156
      Primer pair 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:230261 Racedo SE, et al., Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation. Am J Hum Genet. 2015 Feb 5;96(2):235-44

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory