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Trim63 Gene Detail
Summary
  • Symbol
    Trim63
  • Name
    tripartite motif-containing 63
  • Synonyms
    MuRF1, Rnf28
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447992
    NCBI Gene: 433766
  • Gene Overview
    MyGene.info: TRIM63
Location & Maps
more
  • Sequence Map
    Chr4:134315122-134329628 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14507 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 66.58 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TRIM63, tripartite motif containing 63
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRIM63, tripartite motif containing 63
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IRF, MURF1, MURF2, RNF28, SMRZ
  • Links
    NCBI Gene ID: 84676
    neXtProt AC: NX_Q969Q1

  • Chr Location
    1p34-p33; chr1:26051304-26067634 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 4 alleles in 4 genetic backgrounds
    17 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    4 involving Trim63
  • Incidental Mutations
A targeted homozygous mutation in this gene results in resistance to skeletal muscle atrophy in response to nerve injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010606 VEGA Gene Model | MGI Sequence Detail 14507 C57BL/6J ±  kb
transcript OTTMUST00000024781 VEGA | MGI Sequence Detail 1855 Not Applicable  
polypeptide OTTMUSP00000011376 VEGA | MGI Sequence Detail 352 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    216 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 12
    cDNA 10
    Primer pair 1
    Other 1

    Microarray probesets 1
References
more
  • Summaries
    All 58
    Developmental Gene Expression 7
    Gene Ontology 9
    Phenotypes 29
  • Earliest
    J:77660 Bodine SC, et al., Identification of ubiquitin ligases required for skeletal muscle atrophy. Science. 2001 Nov 23;294(5547):1704-8
  • Latest
    J:229482 Nagandla H, et al., Defective myogenesis in the absence of the muscle-specific lysine methyltransferase SMYD1. Dev Biol. 2016 Feb 1;410(1):86-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory