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Trim63
Gene Detail
Symbol

Name
ID
Trim63
tripartite motif-containing 63
MGI:2447992
Synonyms
MuRF1, Rnf28
Feature Type
protein coding gene
Genetic Map
Chromosome 4
66.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:134315122-134329628 bp, + strand
From VEGA annotation of GRCm38

  14507 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41878  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TRIM63
Gene Tree: Trim63

Human
homologs
TRIM63, tripartite motif containing 63, E3 ubiquitin protein ligase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 84676
neXtProt AC: NX_Q969Q1

Human Synonyms: IRF, MURF1, MURF2, RNF28, SMRZ

Human Chr (Location): 1p34-p33; chr1:26051304-26067634 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Trim63 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
A targeted homozygous mutation in this gene results in resistance to skeletal muscle atrophy in response to nerve injury.
 
Interactions
Trim63 interacts with 194 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (5)    Tissues (4)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
RT-PCR 4
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase trim63    NEW 
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(1) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000010606 (Evidence)
Ensembl Gene Model ENSMUSG00000028834 (Evidence)
Entrez Gene 433766 (Evidence)
UniGene 331961
DFCI TC1642576, TC1643119
DoTS DT.101276021, DT.110842643, DT.490272
NIA Mouse Gene Index U288118
EC 6.3.2.-
Consensus CDS Project CCDS38914.1
International Mouse Phenotyping Consortium Status Trim63
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010606 VEGA Gene Model | MGI Sequence Detail 14507 C57BL/6J ±  kb
transcript OTTMUST00000024781 VEGA | MGI Sequence Detail 1855 Not Applicable 
polypeptide OTTMUSP00000011376 VEGA | MGI Sequence Detail 352 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(215 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000315 B-box-type zinc finger
InterPro IPR017903 COS domain
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000016663 E3 ubiquitin-protein ligase TRIM63
References
(Earliest) J:77660 Bodine SC, et al., Identification of ubiquitin ligases required for skeletal muscle atrophy. Science. 2001 Nov 23;294(5547):1704-8
(Latest) J:222174 Cenik BK, et al., Severe myopathy in mice lacking the MEF2/SRF-dependent gene leiomodin-3. J Clin Invest. 2015 Apr;125(4):1569-78
All references(58)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory