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Car9
Gene Detail
 Symbol
Name
ID
Car9
carbonic anhydrase 9
MGI:2447188
Synonyms CAIX, MN/CA9
Feature Type protein coding gene
Genetic Map
Chromosome 4
23.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:43506966-43513729 bp, + strand
From VEGA annotation of GRCm38

  6764 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20325  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Car9

Human
homologs
Human Homolog CA9, carbonic anhydrase IX
NCBI Gene ID 768
neXtProt AC  NX_Q16790
Human Synonyms  CAIX, MN
Human Chr (Location)  9p13.3; chr9:35673918-35681159 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for this targeted mutation are viable and fertile but develop hyperplasia of the glandular gastric epithelium with numerous cysts.
 
Phenotype Images(1)
Interactions
Car9 interacts with 106 markers (Mir1b, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process morphogenesis of an epithelium, one-carbon metabolic process, ...
Component basolateral plasma membrane, cell projection, ...
Function carbonate dehydratase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (39)    Tissues (33)    Images (11)
Theiler Stages: 11, 19, 20, 21, 28
Assay TypeResults
Immunohistochemistry 37
RT-PCR 2
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(1) cDNA(21) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006931 (Evidence)
Ensembl Gene ModelENSMUSG00000028463 (Evidence)
Entrez Gene230099 (Evidence)
UniGene283682
DFCITC1582278, TC1596343, TC1629365
DoTSDT.55223535
NIA Mouse Gene IndexU004234
EC4.2.1.1
Consensus CDS ProjectCCDS18099.1
International Mouse Knockout Project StatusCar9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006931 VEGA Gene Model | MGI Sequence Detail 6764 C57BL/6J ±  kb
transcript OTTMUST00000016050 VEGA | MGI Sequence Detail 2023 Not Applicable 
polypeptide OTTMUSP00000007368 VEGA | MGI Sequence Detail 437 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(5)
Polymorphisms SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001148 Alpha carbonic anhydrase
InterPro IPR023561 Carbonic anhydrase, alpha-class
InterPro IPR018338 Carbonic anhydrase, alpha-class, conserved site
InterPro IPR018429 Carbonic anhydrase, CA-IX
Protein Ontology PR:000004926 carbonic anhydrase 9
References (Earliest) J:80329 Gut MO, et al., Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9. Gastroenterology. 2002 Dec;123(6):1889-903
(Latest) J:193048 Wu L, et al., A systematic survey of carbonic anhydrase mRNA expression during Mammalian inner ear development. Dev Dyn. 2013 Mar;242(3):269-80
All references(47)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory