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Car9 Gene Detail
Summary
  • Symbol
    Car9
  • Name
    carbonic anhydrase 9
  • Synonyms
    CAIX, MN/CA9
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447188
    NCBI Gene: 230099
  • Gene Overview
    MyGene.info: CA9
Location & Maps
more
  • Sequence Map
    Chr4:43506966-43513729 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6764 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 23.05 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CA9, carbonic anhydrase 9
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CA9, carbonic anhydrase 9
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAIX, MN
  • Links
    NCBI Gene ID: 768
    neXtProt AC: NX_Q16790

  • Chr Location
    9p13.3; chr9:35673918-35681159 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically and radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Car9
  • Incidental Mutations
Mice homozygous for this targeted mutation are viable and fertile but develop hyperplasia of the glandular gastric epithelium with numerous cysts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006931 VEGA Gene Model | MGI Sequence Detail 6764 C57BL/6J ±  kb
transcript OTTMUST00000016050 VEGA | MGI Sequence Detail 2023 Not Applicable  
polypeptide OTTMUSP00000007368 VEGA | MGI Sequence Detail 437 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    64 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 24
    Genomic 1
    cDNA 21
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 44
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:80329 Gut MO, et al., Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9. Gastroenterology. 2002 Dec;123(6):1889-903
  • Latest
    J:216097 Reibring CG, et al., Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation. PLoS One. 2014;9(5):e96007

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory