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Kif18a Gene Detail
Summary
  • Symbol
    Kif18a
  • Name
    kinesin family member 18A
  • Synonyms
    B130001M12Rik, gcd2, MGC:27627, N-8 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446977
    NCBI Gene: 228421
  • Gene Overview
    MyGene.info: KIF18A
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:109280738-109341747 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 56.55 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    350 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446977
protein coding gene Chr2:109280738-109341749 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026239
protein coding gene Chr2:111608365-111670072 (+)
A/J MGP_AJ_G0026200
protein coding gene Chr2:106926434-106987920 (+)
AKR/J MGP_AKRJ_G0026180
protein coding gene Chr2:109945554-110005765 (+)
BALB/cJ MGP_BALBcJ_G0026209
protein coding gene Chr2:107197093-107258200 (+)
C3H/HeJ MGP_C3HHeJ_G0025959
protein coding gene Chr2:110229511-110289656 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026660
protein coding gene Chr2:115250223-115317673 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024046
protein coding gene Chr2:102530975-102589309 (+)
CAST/EiJ MGP_CASTEiJ_G0025424
protein coding gene Chr2:110720725-110786543 (+)
CBA/J MGP_CBAJ_G0025937
protein coding gene Chr2:119246289-119310240 (+)
DBA/2J MGP_DBA2J_G0026075
protein coding gene Chr2:106437832-106499796 (+)
FVB/NJ MGP_FVBNJ_G0026038
protein coding gene Chr2:105364356-105424233 (+)
LP/J MGP_LPJ_G0026178
protein coding gene Chr2:111782794-111845380 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026062
protein coding gene Chr2:123352036-123424213 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026714
protein coding gene Chr2:110084787-110148221 (+)
PWK/PhJ MGP_PWKPhJ_G0025159
protein coding gene Chr2:106074743-106137262 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024959
protein coding gene Chr2:109315266-109371963 (+)
WSB/EiJ MGP_WSBEiJ_G0025491
protein coding gene Chr2:110847728-110913253 (+)



Homology
more
  • Human Ortholog
    KIF18A, kinesin family member 18A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KIF18A, kinesin family member 18A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MS-KIF18A, PPP1R99
  • Links
    NCBI Gene ID: 81930
    neXtProt AC: NX_Q8NI77
    UniProt: Q8NI77

  • Chr Location
    11p14.1; chr11:28020616-28108199 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41820
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KIF18A
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 2 alleles in 5 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for loss of function alleles exhibit reduced female fertility and male infertility due to primordial germ cell depletion. The sterility phenotype is incompletely penetrant, has variable expressivity, and is modulated by strain background.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027115 Ensembl Gene Model | MGI Sequence Detail 61010 C57BL/6J ±  kb
    transcript ENSMUST00000028527 Ensembl | MGI Sequence Detail 3369 Not Applicable  
    polypeptide ENSMUSP00000028527 Ensembl | MGI Sequence Detail 886 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      cDNA 59
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139208, MGI:2444495, MGI:3050505
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:222418 Czechanski A, et al., Kif18a is specifically required for mitotic progression during germ line development. Dev Biol. 2015 Jun 15;402(2):253-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory