Kif18a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Kif18a
kinesin family member 18A
MGI:2446977

33 phenotypes from 2 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Kif18a^gcd2/Kif18a^gcd2 B6.129S1-Kif18a^gcd2/JcsJ	female infertility	J:111998
	infertility	J:111998
	male infertility	J:111998
Kif18a^gcd2/Kif18a^gcd2 CAST.129S1(B6)-Kif18a^gcd2/JcsJ	decreased germ cell number	J:111998
	decreased male germ cell number	J:111998
	decreased oocyte number	J:111998
	decreased primordial germ cell number	J:111998
	embryonic lethality, incomplete penetrance	J:111998
	female infertility	J:111998
	infertility	J:111998
	male infertility	J:111998
Kif18a^gcd2/Kif18a^gcd2 CAST.129S1(B6)-Kif18a^gcd2/JcsMmjax	abnormal cell cycle checkpoint function	J:222418
	abnormal cell physiology	J:222418
	abnormal mitosis	J:222418
	abnormal mitotic spindle assembly checkpoint	J:222418
	abnormal mitotic spindle morphology	J:222418
	abnormal spermatogonia morphology	J:222418
	decreased fibroblast proliferation	J:222418
	decreased germ cell number	J:222418
	increased apoptosis	J:222418
	infertility	J:222418
Kif18a^gcd2/Kif18a^gcd2 involves: 129S1/Sv * C57BL/6	abnormal gametogenesis	J:86161
	abnormal ovarian follicle number	J:111998
	abnormal ovary morphology	J:111998
	abnormal spermatogenesis	J:86161, J:111998
	decreased germ cell number	J:86161, J:111998
	decreased male germ cell number	J:111998
	decreased oocyte number	J:111998
	infertility	J:86161
	premature ovarian failure	J:111998
	normal reproductive system phenotype	J:86161
	small ovary	J:111998
Kif18a^tm1Zgwg/Kif18a^tm1Zgwg either: 129-Kif18a^tm1Zgwg or (involves: 129 * C57BL/6J)	abnormal mitosis	J:211103
	abnormal seminiferous tubule morphology	J:211103
	abnormal testis development	J:211103
	arrest of male meiosis	J:211103
	decreased cell proliferation	J:211103
	decreased testis weight	J:211103
	increased Leydig cell number	J:211103
	increased male germ cell apoptosis	J:211103
	male infertility	J:211103
	reduced female fertility	J:211103
	normal reproductive system phenotype	J:211103
	seminiferous tubule degeneration	J:211103
	testicular atrophy	J:211103

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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