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Sik3
Gene Detail
Symbol

Name
ID
Sik3
SIK family kinase 3
MGI:2446296
Synonyms
5730525O22Rik, 9030204A07Rik, mKIAA0999
Feature Type
protein coding gene
Genetic Map
Chromosome 9
25.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:46012820-46224194 bp, + strand
From VEGA annotation of GRCm38

  211375 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:57023  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sik3

Human
homologs
Human Homolog SIK3, SIK family kinase 3
NCBI Gene ID 23387
neXtProt AC  NX_Q9Y2K2
Human Synonyms  QSK, SIK-3
Human Chr (Location)  11q23.3; chr11:116843402-117098415 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(58) : Gene trapped(55) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired chondrocyte hypertrophy during development, neonatal lethality and reduced size.
 
Interactions
Sik3 interacts with 326 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cartilage development involved in endochondral bone morphogenesis, endochondral ossification, ...
Component cytoplasm
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (8)    Tissues (2)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 8
cDNA source data(70)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(70) cDNA(70)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000028702 (Evidence)
Ensembl Gene ModelENSMUSG00000034135 (Evidence)
Entrez Gene70661 (Evidence)
UniGene219459
DFCITC1583680, TC1669263, TC1578880
DoTSDT.40162046, DT.527399
NIA Mouse Gene IndexU010432
EC2.7.11.1
Consensus CDS ProjectCCDS23140.2
International Mouse Knockout Project StatusSik3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028702 VEGA Gene Model | MGI Sequence Detail 211375 C57BL/6J ±  kb
transcript OTTMUST00000071079 VEGA | MGI Sequence Detail 6287 Not Applicable 
polypeptide OTTMUSP00000036344 VEGA | MGI Sequence Detail 1369 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(4) UniProt(11)
Polymorphisms
SNPs within 2kb(1716 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1748)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
Protein Ontology PR:000013573 serine/threonine-protein kinase QSK
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190393 Clark K, et al., Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91
All references(40)
Other
accession IDs
MGI:1917911, MGI:1924411, MGI:2143048, MGI:2143140, MGI:2143148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory