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Sik3 Gene Detail
Summary
  • Symbol
    Sik3
  • Name
    SIK family kinase 3
  • Synonyms
    5730525O22Rik, 9030204A07Rik, mKIAA0999
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446296
    NCBI Gene: 70661
  • Gene Overview
    MyGene.info: SIK3
Location & Maps
more
  • Sequence Map
    Chr9:46012820-46224194 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      211375 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 25.36 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SIK3, SIK family kinase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SIK3, SIK family kinase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    L19, QSK, SIK-3
  • Links
    NCBI Gene ID: 23387
    neXtProt AC: NX_Q9Y2K2

  • Chr Location
    11q23.3; chr11:116843402-117098453 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 57023
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: SIK3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    74 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired chondrocyte hypertrophy during development, neonatal lethality and reduced size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028702 VEGA Gene Model | MGI Sequence Detail 211375 C57BL/6J ±  kb
transcript OTTMUST00000071079 VEGA | MGI Sequence Detail 6287 Not Applicable  
polypeptide OTTMUSP00000036344 VEGA | MGI Sequence Detail 1369 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1684 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 70
    cDNA 70

    Microarray probesets 8
Other
Accession IDs
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MGI:1917911, MGI:1924411, MGI:2143048, MGI:2143140, MGI:2143148
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:190393 Clark K, et al., Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory