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Sik3 Gene Detail
Summary
  • Symbol
    Sik3
  • Name
    SIK family kinase 3
  • Synonyms
    5730525O22Rik, 9030204A07Rik, mKIAA0999
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446296
    NCBI Gene: 70661
  • Gene Overview
    MyGene.info: SIK3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:46012820-46224194 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 25.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1684 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446296
protein coding gene Chr9:46012820-46224194 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034747
protein coding gene Chr9:44623491-44854245 (+)
A/J MGP_AJ_G0034728
protein coding gene Chr9:43359332-43569965 (+)
AKR/J MGP_AKRJ_G0034655
protein coding gene Chr9:44242577-44458157 (+)
BALB/cJ MGP_BALBcJ_G0034719
protein coding gene Chr9:43081515-43291476 (+)
C3H/HeJ MGP_C3HHeJ_G0034430
protein coding gene Chr9:44720203-44932199 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035240
protein coding gene Chr9:45910945-46135059 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032154
protein coding gene Chr9:42896168-43100611 (+)
CAST/EiJ MGP_CASTEiJ_G0033752
protein coding gene Chr9:44575555-44790253 (+)
CBA/J MGP_CBAJ_G0034402
protein coding gene Chr9:47584301-47820279 (+)
DBA/2J MGP_DBA2J_G0034561
protein coding gene Chr9:43232483-43441249 (+)
FVB/NJ MGP_FVBNJ_G0034502
protein coding gene Chr9:42499097-42705004 (+)
LP/J MGP_LPJ_G0034642
protein coding gene Chr9:44938941-45172766 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034546
protein coding gene Chr9:49359500-49568947 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035261
protein coding gene Chr9:44156840-44377277 (+)
PWK/PhJ MGP_PWKPhJ_G0033457
protein coding gene Chr9:43145004-43360213 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033293
protein coding gene Chr9:44481956-44705873 (+)
WSB/EiJ MGP_WSBEiJ_G0033865
protein coding gene Chr9:44208079-44426268 (+)



Homology
more
  • Human Ortholog
    SIK3, SIK family kinase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SIK3, SIK family kinase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    L19, QSK, SEMDK, SIK-3
  • Links
    NCBI Gene ID: 23387
    neXtProt AC: NX_Q9Y2K2
    UniProt: Q9Y2K2

  • Chr Location
    11q23.3; chr11:116843402-117098453 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 57023
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SIK3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    79 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired chondrocyte hypertrophy during development, neonatal lethality and reduced size. Mice homozygous for a gain of function ENU mutation exhibit decreased total wake time, owing to an increase in inherent sleep need.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70661 NCBI Gene Model | MGI Sequence Detail 211375 C57BL/6J ±  kb
    transcript NM_027498 RefSeq | MGI Sequence Detail 6296 C57BL/6  
    polypeptide Q6P4S6 UniProt | EBI | MGI Sequence Detail 1311 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • EC
    • InterPro Domains
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR034672 Salt-Inducible kinase, catalytic domain
      IPR008271 Serine/threonine-protein kinase, active site
      IPR015940 Ubiquitin-associated domain
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 71

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1917911, MGI:1924411, MGI:2143048, MGI:2143140, MGI:2143148
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:266567 Honda T, et al., A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10458-10463

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory