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Fbxo2
Gene Detail
 Symbol
Name
ID
Fbxo2
F-box protein 2
MGI:2446216
Synonyms Fbs1, FBX2, MGC:54895, NFB42, Prpl4
Feature Type protein coding gene
Genetic Map
Chromosome 4
78.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:148160621-148166424 bp, + strand
From VEGA annotation of GRCm38

  5804 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8132  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fbxo2

Human
homologs
Human Homolog FBXO2, F-box protein 2
NCBI Gene ID 26232
neXtProt AC  NX_Q9UK22
Human Synonyms  FBG1, Fbs1, FBX2, NFB42, OCP1
Human Chr (Location)  1p36.22; chr1:11647868-11654831 (-)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted mutation are behaviorally normal but display accelerated, age-related hearing loss associated with cochlear degeneration. Cellular degeneration begins at 2 months in the supporting cells of the organ of Corti and progresses to cochlear hair cells and the spiral ganglion.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process ER-associated ubiquitin-dependent protein catabolic process, glycoprotein catabolic process, ...
Component cytoplasm, cytosol, ...
Function beta-amyloid binding, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (23)    Tissues (14)    Images (7)
Theiler Stages: 21, 23, 28
Assay TypeResults
RNA in situ 6
Northern blot 17
cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(20) cDNA(20)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000010936 (Evidence)
Ensembl Gene ModelENSMUSG00000041556 (Evidence)
Entrez Gene230904 (Evidence)
UniGene262287
DFCITC1578506
DoTSDT.97390985
NIA Mouse Gene IndexU005084
PDB1UMH, 1UMI, 2E31, 2E32, 2E33, 2RJ2
Consensus CDS ProjectCCDS18935.1
International Mouse Knockout Project StatusFbxo2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010936 VEGA Gene Model | MGI Sequence Detail 5804 C57BL/6J ±  kb
transcript OTTMUST00000025652 VEGA | MGI Sequence Detail 1288 Not Applicable 
polypeptide OTTMUSP00000011756 VEGA | MGI Sequence Detail 297 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(6) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(58 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007397 F-box associated (FBA) domain
InterPro IPR001810 F-box domain, cyclin-like
InterPro IPR008979 Galactose-binding domain-like
Protein Ontology PR:000007393 F-box only protein 2
References (Earliest) J:39869 Yehiely F, et al., Identification of candidate proteins binding to prion protein. Neurobiol Dis. 1997;3(4):339-55
(Latest) J:192485 Gordon KL, et al., The ubiquitin ligase F-box/G-domain protein 1 promotes the degradation of the disease-linked protein torsinA through the ubiquitin-proteasome pathway and macroautophagy. Neuroscience. 2012 Nov 8;224:160-71
All references(39)
Other
accession IDs
MGI:892993

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory