Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables amyloid-beta binding activity; carbohydrate binding activity; and denatured protein binding activity. Involved in protein catabolic process; protein ubiquitination; and regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Acts upstream of or within ERAD pathway; regulation of protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol and dendritic spine. Part of SCF ubiquitin ligase complex. Is active in glutamatergic synapse. Is expressed in brain; testis; and vestibulo-cochlear ganglion. Orthologous to human FBXO2 (F-box protein 2).