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Flnb
Gene Detail
Symbol

Name
ID
Flnb
filamin, beta
MGI:2446089
Feature Type
protein coding gene
Genetic Map
Chromosome 14
4.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:7817957-7951588 bp, + strand
From VEGA annotation of GRCm38

  133632 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37480  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: FLNB
Gene Tree: Flnb

Human
homologs
FLNB, filamin B, beta
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2317
neXtProt AC: NX_O75369

Human Synonyms: ABP-278, ABP-280, AOI, FH1, FLN1L, FLN-B, LRS1, SCT, TABP, TAP

Human Chr (Location): 3p14.3; chr3:58008400-58172255 (+)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human FLNB

Mutations,
alleles, and
phenotypes
All mutations/alleles(127) : Chemically induced (ENU)(1) Gene trapped(122) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mouse homozygous for disruption of coding region due to a gene trapped vector exhibit partial prenatal and postnatal lethality, alteration in skeletal system including fusion of vertebrae and other skeletal elements.
 
Human Diseases Modeled in Mice Using Flnb (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Flnb interacts with 217 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process actin cytoskeleton organization, cell differentiation, ...
Component brush border, cytoplasm, ...
Function actin binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (190)    Tissues (55)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 168
In situ reporter (knock in) 17
Western blot 3
RT-PCR 2
cDNA source data(33)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase flnb    NEW 
Molecular
reagents
All nucleic(34) cDNA(33) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000036302 (Evidence)
Ensembl Gene Model ENSMUSG00000025278 (Evidence)
Entrez Gene 286940 (Evidence)
DFCI TC1623420, TC1618296, TC1615670, TC1592853, TC1584378, TC1641814, TC1697376, TC1650762, TC1715995
DoTS DT.87069093, DT.87071266, DT.101387837, DT.486239, DT.101358878, DT.110768932, DT.99845859, DT.91433794, DT.101125414
NIA Mouse Gene Index U015289, U351618
Consensus CDS Project CCDS70540.1
International Mouse Phenotyping Consortium Status Flnb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036302 VEGA Gene Model | MGI Sequence Detail 133632 C57BL/6J ±  kb
transcript OTTMUST00000093156 VEGA | MGI Sequence Detail 9100 Not Applicable 
polypeptide OTTMUSP00000051606 VEGA | MGI Sequence Detail 2602 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(720 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001589 Actinin-type, actin-binding, conserved site
InterPro IPR001715 Calponin homology domain
InterPro IPR001298 Filamin/ABP280 repeat
InterPro IPR017868 Filamin/ABP280 repeat-like
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000007556 filamin-B
References
(Earliest) J:79977 Sheen VL, et al., Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact. Hum Mol Genet. 2002 Nov 1;11(23):2845-54
(Latest) J:213598 Hu J, et al., Formin 1 and filamin B physically interact to coordinate chondrocyte proliferation and differentiation in the growth plate. Hum Mol Genet. 2014 Sep 1;23(17):4663-73
All references(50)
Disease annotation references (2)
Other
accession IDs
MGI:2145716

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory