Flnb
Gene Detail

Symbol Name ID

Flnb filamin, beta MGI:2446089

Feature Type

protein coding gene

Genetic Map

Chromosome 14

4.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:7817957-7951588 bp, + strand From VEGA annotation of GRCm38   133632 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37480  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Flnb

Human homologs

Human Homolog		FLNB, filamin B, beta
NCBI Gene ID		2317
neXtProt AC		NX_O75369
Human Synonyms		ABP-278, ABP-280, AOI, FH1, FLN1L, FLN-B, LRS1, SCT, TABP, TAP
Human Chr (Location)		3p14.3; chr3:57994127-58157982 (+)  GRCh37.p10
Disease Associations		(5) Diseases Associated with Human FLNB

Alleles and phenotypes

All alleles(124) : Targeted(2) Gene trapped(122)
 

Mouse homozygous for disruption of coding region due to a gene trapped vector exhibit partial prenatal and postnatal lethality, alteration in skeletal system including fusion of vertebrae and other skeletal elements.

 
Human Diseases Modeled Using Mouse Flnb (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	skeletal muscle tissue development
Component	cytoplasm, cytoskeleton, ...
Function	actin binding, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (190)    Tissues (55)    Images (24)
Theiler Stages: 17, 21, 22, 23, 28

Assay Type	Results
RNA in situ	168
In situ reporter (knock in)	17
Western blot	3
RT-PCR	2

cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) cDNA(29) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000036302 (Evidence)
Ensembl Gene Model	ENSMUSG00000025278 (Evidence)
Entrez Gene	286940 (Evidence)
DFCI	TC1584378, TC1592853, TC1615670, TC1618296, TC1623420, TC1641814, TC1650762, TC1697376, TC1715995
DoTS	DT.101125414, DT.101358878, DT.101387837, DT.110768932, DT.486239, DT.87069093, DT.87071266, DT.91433794, DT.99845859
NIA Mouse Gene Index	U015289, U351618
International Mouse Knockout Project Status	Flnb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036302	VEGA Gene Model | MGI Sequence Detail	133632	C57BL/6J
transcript	OTTMUST00000093156	VEGA | MGI Sequence Detail	9100	Not Applicable
polypeptide	OTTMUSP00000051606	VEGA | MGI Sequence Detail	2602	Not Applicable

All sequences(73) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(617 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001589	Actinin-type, actin-binding, conserved site
InterPro	IPR001715	Calponin homology domain
InterPro	IPR001298	Filamin/ABP280 repeat
InterPro	IPR017868	Filamin/ABP280 repeat-like
InterPro	IPR014756	Immunoglobulin E-set
InterPro	IPR013783	Immunoglobulin-like fold
Protein Ontology	PR:000007556	filamin-B

References

(Earliest) J:79977 Sheen VL, et al., Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact. Hum Mol Genet. 2002 Nov 1;11(23):2845-54
(Latest) J:185743 Cotney J, et al., Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb. Genome Res. 2012 Jun;22(6):1069-80
All references(42)

Other accession IDs

MGI:2145716