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Flnb
Gene Detail
 Symbol
Name
ID
Flnb
filamin, beta
MGI:2446089
Feature Type protein coding gene
Genetic Map
Chromosome 14
4.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:7817957-7951588 bp, + strand
From VEGA annotation of GRCm38

  133632 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37480  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Flnb

Human
homologs
Human Homolog FLNB, filamin B, beta
NCBI Gene ID 2317
neXtProt AC  NX_O75369
Human Synonyms  ABP-278, ABP-280, AOI, FH1, FLN1L, FLN-B, LRS1, SCT, TABP, TAP
Human Chr (Location)  3p14.3; chr3:58008400-58172255 (+)  GRCh38
Disease Associations  (5) Diseases Associated with Human FLNB
Alleles
and
phenotypes
All alleles(124) : Targeted(2) Gene trapped(122)
 
Mouse homozygous for disruption of coding region due to a gene trapped vector exhibit partial prenatal and postnatal lethality, alteration in skeletal system including fusion of vertebrae and other skeletal elements.
 
Human Diseases Modeled Using Mouse Flnb (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process skeletal muscle tissue development
Component cytoplasm, cytoskeleton, ...
Function actin binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (190)    Tissues (55)    Images (24)
Theiler Stages: 17, 21, 22, 23, 28
Assay TypeResults
RNA in situ 168
In situ reporter (knock in) 17
Western blot 3
RT-PCR 2
cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(34) cDNA(33) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000036302 (Evidence)
Ensembl Gene ModelENSMUSG00000025278 (Evidence)
Entrez Gene286940 (Evidence)
DFCITC1584378, TC1592853, TC1615670, TC1618296, TC1623420, TC1641814, TC1650762, TC1697376, TC1715995
DoTSDT.101125414, DT.101358878, DT.101387837, DT.110768932, DT.486239, DT.87069093, DT.87071266, DT.91433794, DT.99845859
NIA Mouse Gene IndexU015289, U351618
International Mouse Knockout Project StatusFlnb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036302 VEGA Gene Model | MGI Sequence Detail 133632 C57BL/6J ±  kb
transcript OTTMUST00000093156 VEGA | MGI Sequence Detail 9100 Not Applicable 
polypeptide OTTMUSP00000051606 VEGA | MGI Sequence Detail 2602 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(720 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001589 Actinin-type, actin-binding, conserved site
InterPro IPR001715 Calponin homology domain
InterPro IPR001298 Filamin/ABP280 repeat
InterPro IPR017868 Filamin/ABP280 repeat-like
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000007556 filamin-B
References (Earliest) J:79977 Sheen VL, et al., Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact. Hum Mol Genet. 2002 Nov 1;11(23):2845-54
(Latest) J:185743 Cotney J, et al., Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb. Genome Res. 2012 Jun;22(6):1069-80
All references(42)
Other
accession IDs
MGI:2145716

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory