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Plac8
Gene Detail
 Symbol
Name
ID
Plac8
placenta-specific 8
MGI:2445289
Synonyms C15, D5Wsu111e, onzin
Feature Type protein coding gene
Genetic Map
Chromosome 5
48.49 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:100553725-100572245 bp, - strand
From VEGA annotation of GRCm38

  18521 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32328  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Gene Tree: Plac8

Human
homologs
Human Homolog PLAC8, placenta-specific 8
NCBI Gene ID 51316
neXtProt AC  NX_Q9NZF1
Human Synonyms  C15, DGIC, onzin
Human Chr (Location)  4q21.22; chr4:83090048-83114758 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit decreased neutrophil capacity for intracellular bacteria killing.
 
Interactions
Plac8 interacts with 38 markers (Mir16-2, Mir22, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process brown fat cell differentiation, defense response to bacterium, ...
Component nucleus
Function chromatin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (85)    Tissues (14)    Images (25)
Theiler Stages: 11, 23, 28
Assay TypeResults
RNA in situ 76
RT-PCR 9
cDNA source data(108)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(110) cDNA(108) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026150 (Evidence)
Ensembl Gene ModelENSMUSG00000029322 (Evidence)
Entrez Gene231507 (Evidence)
UniGene34609
DFCITC1576362, TC1712270
DoTSDT.495589, DT.495590
NIA Mouse Gene IndexU026453
Consensus CDS ProjectCCDS19464.1
International Mouse Knockout Project StatusPlac8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026150 VEGA Gene Model | MGI Sequence Detail 18521 C57BL/6J ±  kb
transcript OTTMUST00000064589 VEGA | MGI Sequence Detail 738 Not Applicable 
polypeptide OTTMUSP00000032102 VEGA | MGI Sequence Detail 112 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006461 Uncharacterised protein family Cys-rich
Protein Ontology PR:000012819 placenta-specific gene 8 protein
References (Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:211801 Kinsey C, et al., Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression. Cell Rep. 2014 May 22;7(4):1143-55
All references(42)
Other
accession IDs
MGD-MRK-34174, MGI:106480

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory