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Senp1 Gene Detail
Summary
  • Symbol
    Senp1
  • Name
    SUMO1/sentrin specific peptidase 1
  • Synonyms
    2310046A20Rik, D15Ertd528e, E330036L07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445054
    NCBI Gene: 223870
  • Gene Overview
    MyGene.info: SENP1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:98038744-98093744 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 54.04 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    338 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445054
protein coding gene Chr15:98038744-98093967 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022284
protein coding gene Chr15:99728121-99785310 (-)
A/J MGP_AJ_G0022243
protein coding gene Chr15:95779877-95836574 (-)
AKR/J MGP_AKRJ_G0022218
protein coding gene Chr15:98676206-98729999 (-)
BALB/cJ MGP_BALBcJ_G0022249
protein coding gene Chr15:96008040-96061226 (-)
C3H/HeJ MGP_C3HHeJ_G0022019
protein coding gene Chr15:98745986-98802269 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022694
protein coding gene Chr15:103412914-103468453 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020220
protein coding gene Chr15:91727746-91786692 (-)
CAST/EiJ MGP_CASTEiJ_G0021541
protein coding gene Chr15:99626280-99684496 (-)
CBA/J MGP_CBAJ_G0021986
protein coding gene Chr15:106873607-106930394 (-)
DBA/2J MGP_DBA2J_G0022113
protein coding gene Chr15:95234392-95287401 (-)
FVB/NJ MGP_FVBNJ_G0022092
protein coding gene Chr15:94223213-94276220 (-)
LP/J MGP_LPJ_G0022184
protein coding gene Chr15:99842610-99898783 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022112
protein coding gene Chr15:110983455-111042803 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022709
protein coding gene Chr15:98824128-98880030 (-)
PWK/PhJ MGP_PWKPhJ_G0021282
protein coding gene Chr15:95339136-95394867 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021116
protein coding gene Chr15:98609133-98663704 (-)
WSB/EiJ MGP_WSBEiJ_G0021590
protein coding gene Chr15:99340963-99397596 (-)



Homology
more
  • Human Ortholog
    SENP1, SUMO specific peptidase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SENP1, SUMO specific peptidase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SuPr-2
  • Links
    NCBI Gene ID: 29843
    neXtProt AC: NX_Q9P0U3
    UniProt: Q9P0U3

  • Chr Location
    12q13.11; chr12:48042893-48106308 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Senp1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 6 alleles in 10 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice die before birth. Depending on the allele mice may exhibit placental labyrinth defects and widespread cell death or severe anemia and a defect in definitive erythropoiesis in the fetal liver.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033075 Ensembl Gene Model | MGI Sequence Detail 55001 C57BL/6J ±  kb
    transcript ENSMUST00000180657 Ensembl | MGI Sequence Detail 3806 Not Applicable  
    polypeptide ENSMUSP00000138056 Ensembl | MGI Sequence Detail 666 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • EC
    • InterPro Domains
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR003653 Ulp1 protease family, C-terminal catalytic domain
    Molecular
    Reagents
    less
    • All nucleic 133
      cDNA 132
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1261822, MGI:1919167
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 11
      Phenotypes 38
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:265740 Wang Y, et al., TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain. Nat Commun. 2018 Apr 18;9(1):1529

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory