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Senp1 Gene Detail
Summary
  • Symbol
    Senp1
  • Name
    SUMO1/sentrin specific peptidase 1
  • Synonyms
    2310046A20Rik, D15Ertd528e, E330036L07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445054
    NCBI Gene: 223870
  • Gene Overview
    MyGene.info: SENP1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:98038744-98093744 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      55001 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 54.04 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SENP1, SUMO specific peptidase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SENP1, SUMO specific peptidase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SuPr-2
  • Links
    NCBI Gene ID: 29843
    neXtProt AC: NX_Q9P0U3
    UniProt: Q9P0U3

  • Chr Location
    12q13.11; chr12:48042893-48106308 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Senp1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 6 alleles in 10 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice die before birth. Depending on the allele mice may exhibit placental labyrinth defects and widespread cell death or severe anemia and a defect in definitive erythropoiesis in the fetal liver.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000042971 VEGA Gene Model | MGI Sequence Detail 55001 C57BL/6J ±  kb
    transcript OTTMUST00000112812 VEGA | MGI Sequence Detail 3806 Not Applicable  
    polypeptide OTTMUSP00000063188 VEGA | MGI Sequence Detail 666 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      338 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • EC
    • InterPro Domains
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR003653 Ulp1 protease family, C-terminal catalytic domain
    Molecular
    Reagents
    less
    • All nucleic 133
      cDNA 132
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1261822, MGI:1919167
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 10
      Phenotypes 37
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:249574 Qiu C, et al., The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis. Nat Commun. 2017 Jun 01;8:15426

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory