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Ppargc1b
Gene Detail
 Symbol
Name
ID
Ppargc1b
peroxisome proliferative activated receptor, gamma, coactivator 1 beta
MGI:2444934
Synonyms 4631412G21Rik, PGC-1beta/ERRL1
Feature Type protein coding gene
Genetic Map
Chromosome 18
34.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:61298136-61400431 bp, - strand
From VEGA annotation of GRCm38

  102296 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15776  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ppargc1b

Human
homologs
Human Homolog PPARGC1B, peroxisome proliferator-activated receptor gamma, coactivator 1 beta
NCBI Gene ID 133522
neXtProt AC  NX_Q86YN6
Human Synonyms  ERRL1, PERC, PGC1B, PGC-1(beta)
Human Chr (Location)  5q32; chr5:149730252-149855022 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PPARGC1B
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene can lead to postnatal lethality and impaired mitochondrial activity, adaptive thermogenesis, and hepatic function. Homozygotes for a null allele also display a defect in heart rate regulation, reduced body weight and WAT content, and increased energy expenditure.
 
Interactions
Ppargc1b interacts with 171 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process actin filament organization, bone trabecula formation, ...
Component mediator complex, mitochondrion, ...
Function AF-2 domain binding, estrogen receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (31)    Tissues (25)    Images (3)
Theiler Stages: 21, 24, 25, 26, 27
Assay TypeResults
RNA in situ 20
RT-PCR 11
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(24) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024012 (Evidence)
Ensembl Gene ModelENSMUSG00000033871 (Evidence)
Entrez Gene170826 (Evidence)
UniGene415302
DFCITC1581365, TC1618130
DoTSDT.101167484, DT.40152570
NIA Mouse Gene IndexU038470
Consensus CDS ProjectCCDS29284.1
International Mouse Knockout Project StatusPpargc1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024012 VEGA Gene Model | MGI Sequence Detail 102296 C57BL/6J ±  kb
transcript OTTMUST00000058872 VEGA | MGI Sequence Detail 3330 Not Applicable 
polypeptide OTTMUSP00000028587 VEGA | MGI Sequence Detail 1030 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(976 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000013060 peroxisome proliferator-activated receptor gamma coactivator 1-beta
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:209523 Lai L, et al., A role for peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1) in the regulation of cardiac mitochondrial phospholipid biosynthesis. J Biol Chem. 2014 Jan 24;289(4):2250-9
All references(59)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory