About   Help   FAQ
Ppargc1b Gene Detail
Summary
  • Symbol
    Ppargc1b
  • Name
    peroxisome proliferative activated receptor, gamma, coactivator 1 beta
  • Synonyms
    4631412G21Rik, PGC-1beta/ERRL1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444934
    NCBI Gene: 170826
  • Gene Overview
    MyGene.info: PPARGC1B
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:61298136-61400431 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 34.41 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1014 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444934
protein coding gene Chr18:61291445-61401462 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024479
protein coding gene Chr18:61181971-61283861 (-)
A/J MGP_AJ_G0024446
protein coding gene Chr18:58548370-58651301 (-)
AKR/J MGP_AKRJ_G0024416
protein coding gene Chr18:60162926-60266543 (-)
BALB/cJ MGP_BALBcJ_G0024445
protein coding gene Chr18:58676709-58779260 (-)
C3H/HeJ MGP_C3HHeJ_G0024213
protein coding gene Chr18:60388982-60499453 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024892
protein coding gene Chr18:62831623-62948640 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022323
protein coding gene Chr18:58092887-58196087 (-)
CAST/EiJ MGP_CASTEiJ_G0023686
protein coding gene Chr18:60261402-60373747 (-)
CBA/J MGP_CBAJ_G0024183
protein coding gene Chr18:64845650-64965860 (-)
DBA/2J MGP_DBA2J_G0024313
protein coding gene Chr18:58215233-58318007 (-)
FVB/NJ MGP_FVBNJ_G0024279
protein coding gene Chr18:57627979-57730666 (-)
LP/J MGP_LPJ_G0024396
protein coding gene Chr18:61020531-61139456 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024308
protein coding gene Chr18:66462784-66574620 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024939
protein coding gene Chr18:60350750-60463482 (-)
PWK/PhJ MGP_PWKPhJ_G0023429
protein coding gene Chr18:58445788-58550687 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023235
protein coding gene Chr18:60589955-60695231 (-)
WSB/EiJ MGP_WSBEiJ_G0023750
protein coding gene Chr18:60217060-60328394 (-)



Homology
more
  • Human Ortholog
    PPARGC1B, PPARG coactivator 1 beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPARGC1B, PPARG coactivator 1 beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ERRL1, PERC, PGC1B, PGC-1(beta)
  • Links
    NCBI Gene ID: 133522
    neXtProt AC: NX_Q86YN6
    UniProt: Q86YN6

  • Chr Location
    5q32; chr5:149730252-149857861 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PPARGC1B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 7 alleles in 7 genetic backgrounds
    19 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene can lead to postnatal lethality and impaired mitochondrial activity, adaptive thermogenesis, and hepatic function. Homozygotes for a null allele also display a defect in heart rate regulation, reduced body weight and WAT content, and increased energy expenditure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033871 Ensembl Gene Model | MGI Sequence Detail 102296 C57BL/6J ±  kb
    transcript ENSMUST00000063307 Ensembl | MGI Sequence Detail 3330 Not Applicable  
    polypeptide ENSMUSP00000069431 Ensembl | MGI Sequence Detail 1030 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000013060 peroxisome proliferator-activated receptor gamma coactivator 1-beta
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR034621 Peroxisome proliferator-activated receptor gamma coactivator 1-beta
      IPR034605 PGC-1
      IPR034177 PPARGC1B, RNA recognition motif
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 24
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 11
      Gene Ontology 10
      Phenotypes 37
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:250512 Li J, et al., CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice. Database (Oxford). 2018;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory