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Chfr Gene Detail
Summary
  • Symbol
    Chfr
  • Name
    checkpoint with forkhead and ring finger domains
  • Synonyms
    5730484M20Rik, RNF116
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444898
    NCBI Gene: 231600
  • Gene Overview
    MyGene.info: CHFR
Location & Maps
more
  • Sequence Map
    Chr5:110135842-110171972 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      36131 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 53.32 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CHFR, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CHFR, checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
    Orthology source: HomoloGene
  • Synonyms
    RNF116, RNF196
  • Links
    NCBI Gene ID: 55743
    neXtProt AC: NX_Q96EP1

  • Chr Location
    12q24.33; chr12:132840352-132887618 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 10078
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CHFR
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Chfr
  • Incidental Mutations
Homozygous null mice and MEFs display increased tumor incidence and inducibility, premature death, increased chromosomal instability, and cell cycle abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054048 VEGA Gene Model | MGI Sequence Detail 36131 C57BL/6J ±  kb
transcript OTTMUST00000134329 VEGA | MGI Sequence Detail 3159 Not Applicable  
polypeptide OTTMUSP00000071250 VEGA | MGI Sequence Detail 664 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    272 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:200220 Liu C, et al., CHFR is important for the first wave of ubiquitination at DNA damage sites. Nucleic Acids Res. 2013 Feb 1;41(3):1698-710

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory