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Chfr Gene Detail
Summary
  • Symbol
    Chfr
  • Name
    checkpoint with forkhead and ring finger domains
  • Synonyms
    5730484M20Rik, RNF116
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444898
    NCBI Gene: 231600
  • Gene Overview
    MyGene.info: CHFR
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:110135842-110171972 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 53.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    272 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444898
protein coding gene Chr5:110135755-110171973 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029880
protein coding gene Chr5:112571972-112614954 (+)
A/J MGP_AJ_G0029845
protein coding gene Chr5:108213579-108252726 (+)
AKR/J MGP_AKRJ_G0029783
protein coding gene Chr5:111660078-111699426 (+)
BALB/cJ MGP_BALBcJ_G0029856
protein coding gene Chr5:109583718-109620183 (+)
C3H/HeJ MGP_C3HHeJ_G0029576
protein coding gene Chr5:112085570-112124829 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030309
protein coding gene Chr5:117017092-117057896 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027538
protein coding gene Chr5:103040938-103079592 (+)
CAST/EiJ MGP_CASTEiJ_G0028984
protein coding gene Chr5:110948817-110987796 (+)
CBA/J MGP_CBAJ_G0029543
protein coding gene Chr5:121415978-121460287 (+)
DBA/2J MGP_DBA2J_G0029693
protein coding gene Chr5:108282500-108320312 (+)
FVB/NJ MGP_FVBNJ_G0029650
protein coding gene Chr5:106959017-106996015 (+)
LP/J MGP_LPJ_G0029781
protein coding gene Chr5:113136384-113177458 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029681
protein coding gene Chr5:126076442-126116034 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030350
protein coding gene Chr5:111094411-111130814 (+)
PWK/PhJ MGP_PWKPhJ_G0028698
protein coding gene Chr5:106870596-106909622 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028536
protein coding gene Chr5:108558787-108598267 (+)
WSB/EiJ MGP_WSBEiJ_G0029060
protein coding gene Chr5:111541269-111577347 (+)



Homology
more
  • Human Ortholog
    CHFR, checkpoint with forkhead and ring finger domains
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CHFR, checkpoint with forkhead and ring finger domains
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RNF116, RNF196
  • Links
    NCBI Gene ID: 55743
    neXtProt AC: NX_Q96EP1
    UniProt: Q96EP1

  • Chr Location
    12q24.33; chr12:132840352-132887618 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10078
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CHFR
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice and MEFs display increased tumor incidence and inducibility, premature death, increased chromosomal instability, and cell cycle abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014668 Ensembl Gene Model | MGI Sequence Detail 36131 C57BL/6J ±  kb
    transcript ENSMUST00000112519 Ensembl | MGI Sequence Detail 3159 Not Applicable  
    polypeptide ENSMUSP00000108138 Ensembl | MGI Sequence Detail 664 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:200220 Liu C, et al., CHFR is important for the first wave of ubiquitination at DNA damage sites. Nucleic Acids Res. 2013 Feb 1;41(3):1698-710

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory