Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including positive regulation of protein metabolic process; protein destabilization; and protein polyubiquitination. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in embryo. Orthologous to human CHFR (checkpoint with forkhead and ring finger domains).