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Mfsd7b
Gene Detail
 Symbol
Name
ID
Mfsd7b
major facilitator superfamily domain containing 7B
MGI:2444881
Synonyms 9630055N22Rik, Flvcr1
Feature Type protein coding gene
Genetic Map
Chromosome 1
96.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:191005832-191026190 bp, - strand
From NCBI annotation of GRCm38

  20359 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56661  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mfsd7b

Human
homologs
Human Homolog FLVCR1, feline leukemia virus subgroup C cellular receptor 1
NCBI Gene ID 28982
neXtProt AC  NX_Q9Y5Y0
Human Synonyms  AXPC1, FLVCR, MFSD7B, PCA, PCARP
Human Chr (Location)  1q32.3; chr1:212858255-212899363 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FLVCR1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit runting, cardiomegaly and splenomegaly, lack definitive erythropoiesis, develop severe hyperchromic macrocytic anemia and reticulocytopenia, and show craniofacial and limb defects and intrauterine lethality modulated by genetic background.
 
Interactions
Mfsd7b interacts with 306 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process blood vessel development, embryonic digit morphogenesis, ...
Component integral component of membrane, membrane, ...
Function heme transporter activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (21)    Tissues (10)   
Theiler Stages: 11, 13, 28
Assay TypeResults
RNA in situ 9
Western blot 6
RT-PCR 6
cDNA source data(38)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) cDNA(38) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000066595 (Evidence)
Entrez Gene226844 (Evidence)
UniGene134053
DFCITC1597738, TC1610937
Consensus CDS ProjectCCDS35823.1
International Mouse Knockout Project StatusMfsd7b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 226844 NCBI Gene Model | MGI Sequence Detail 20359 C57BL/6J ±  kb
transcript NM_001081259 RefSeq | MGI Sequence Detail 4087 Not Specified 
polypeptide B2RXV4 UniProt | EBI | MGI Sequence Detail 560 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
Protein Ontology PR:000007566 feline leukemia virus subgroup C receptor-related protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:204083 Byon JC, et al., FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function. Blood. 2013 Oct 17;122(16):2903-10
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory