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Mfsd7b
Gene Detail
Symbol

Name
ID
Mfsd7b
major facilitator superfamily domain containing 7B
MGI:2444881
Synonyms
9630055N22Rik, Flvcr1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
96.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:191005847-191026158 bp, - strand
From VEGA annotation of GRCm38

  20312 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56661  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FLVCR1
Gene Tree: Mfsd7b

Human
homologs
FLVCR1, feline leukemia virus subgroup C cellular receptor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 28982
neXtProt AC: NX_Q9Y5Y0

Human Synonyms: AXPC1, FLVCR, MFSD7B, PCA, PCARP

Human Chr (Location): 1q32.3; chr1:212858255-212899363 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FLVCR1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit runting, cardiomegaly and splenomegaly, lack definitive erythropoiesis, develop severe hyperchromic macrocytic anemia and reticulocytopenia, and show craniofacial and limb defects and intrauterine lethality modulated by genetic background.
 
Interactions
Mfsd7b interacts with 306 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process blood vessel development, embryonic digit morphogenesis, ...
Component integral component of membrane, membrane, ...
Function heme transporter activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (21)    Tissues (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 9
Western blot 6
RT-PCR 6
cDNA source data(38)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) cDNA(38) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000051405 (Evidence)
Ensembl Gene Model ENSMUSG00000066595 (Evidence)
Entrez Gene 226844 (Evidence)
UniGene 134053
DFCI TC1597738, TC1610937
Consensus CDS Project CCDS35823.1
International Mouse Phenotyping Consortium Status Mfsd7b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051405 VEGA Gene Model | MGI Sequence Detail 20312 C57BL/6J ±  kb
transcript OTTMUST00000129956 VEGA | MGI Sequence Detail 4040 Not Applicable 
polypeptide OTTMUSP00000069734 VEGA | MGI Sequence Detail 560 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
Protein Ontology PR:000007566 feline leukemia virus subgroup C receptor-related protein 1
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:204083 Byon JC, et al., FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function. Blood. 2013 Oct 17;122(16):2903-10
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory